JPS55151582A - Preparation of piperazinyl benzheterocyclic carboxylic acid ddrivative - Google Patents
Preparation of piperazinyl benzheterocyclic carboxylic acid ddrivativeInfo
- Publication number
- JPS55151582A JPS55151582A JP5944379A JP5944379A JPS55151582A JP S55151582 A JPS55151582 A JP S55151582A JP 5944379 A JP5944379 A JP 5944379A JP 5944379 A JP5944379 A JP 5944379A JP S55151582 A JPS55151582 A JP S55151582A
- Authority
- JP
- Japan
- Prior art keywords
- carboxylic acid
- formula
- lower alkyl
- piperazinyl
- compound shown
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A piperazinylbenzheterocyclic carboxylic acid derivative shown by the formula I (R<1> is H or lower alkyl; R<2> is H, lower alkyl, benzoyl, etc.; R<3> is H or halogen; n is 1 or 2) and its salt. EXAMPLE:8-( 1-Piperazinyl )-5-methyl-6,7-dihydro-1-oxo-1H,5H-benz[ ij ]quinolizine-2-carboxylic acid. USE:Antibacterial agents. Having an activity against a Gram-positive and a Gram- negative bacteria, especially against bacteria of the genus Streptococcus, Pseudomonas, etc. PROCESS:A novel compound shown by the formula II (R<4> and R<5> are H or lower alkyl) is reacted with a tertiary nitrogen atom-containing aromatic heterocyclic compound, e.g., pyridine, picoline, etc. or a trialkylamine, e.g., trimethyl-amine and an anion donor compound, e.g., chlorine, sulfuric acid, etc. to give a compound shown by the formula III (Y<+> is trialkyl ammonium, etc.; Z<-> is an anion), which is hydrolyzed to prepare a compound shown by the formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5944379A JPS6037115B2 (en) | 1979-05-15 | 1979-05-15 | Method for producing piperazinyl benzoheterocyclic carboxylic acid derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5944379A JPS6037115B2 (en) | 1979-05-15 | 1979-05-15 | Method for producing piperazinyl benzoheterocyclic carboxylic acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55151582A true JPS55151582A (en) | 1980-11-26 |
JPS6037115B2 JPS6037115B2 (en) | 1985-08-24 |
Family
ID=13113428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5944379A Expired JPS6037115B2 (en) | 1979-05-15 | 1979-05-15 | Method for producing piperazinyl benzoheterocyclic carboxylic acid derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6037115B2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63141515U (en) * | 1987-03-08 | 1988-09-19 |
-
1979
- 1979-05-15 JP JP5944379A patent/JPS6037115B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6037115B2 (en) | 1985-08-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5649382A (en) | 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt | |
ES8104233A1 (en) | Quinoline carboxylic acid derivatives | |
GB949088A (en) | Diazabicyclo-octane derivatives | |
JPS55113765A (en) | Quinolinecarboxylic acid derivative | |
ES8600274A1 (en) | Benzoquinolizine carboxylic acid derivatives, and process for preparation thereof | |
IE33535L (en) | Penicillins | |
SE7810295L (en) | SUBSTITUTED KINOLIN CARBOXYLIC ACID | |
JPS5547688A (en) | Novel cephem compound and its preparation | |
JPS5653656A (en) | Quinoline derivative and its preparation | |
JPS6479188A (en) | 3,7-disubstituted-2-or 3-cephem-4-carboxylic acid compound or intermediate for salts thereof | |
JPS55151582A (en) | Preparation of piperazinyl benzheterocyclic carboxylic acid ddrivative | |
JPS5643288A (en) | Cephalosporin derivative and its preparation | |
IE791277L (en) | PYRAZOLO (3,4-b) PYRIDINES | |
JPS5576875A (en) | Benzo ij quinolizine-2-carboxylic acid derivative and its preparation | |
JPS5788182A (en) | Pyrido(1,2,3-de)(1,4)benzoxazinecarboxylic acid derivative | |
JPS5655388A (en) | Benzo ij quinolidine-2-carboxylic acid derivative, and its preparation | |
JPS5540656A (en) | Substituted quinoline-carboxylic acid derivative | |
JPS55124790A (en) | Cephem compound, its preparation and antimicrobials consisting the same mainly | |
JPS5564588A (en) | Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation | |
US3692774A (en) | 2-carboxamido penicillin derivatives | |
JPS565484A (en) | Cephalosporin derivative and its salt | |
JPS5788183A (en) | Pyridobenzoxazine derivative | |
JPS5572196A (en) | Penicillanic acid derivative | |
JPS55136292A (en) | Cephalosporin derivative, its preparation, and antibacterial comprising it | |
JPS55153792A (en) | Cephalosporanic acid derivative |