JPS55151582A - Preparation of piperazinyl benzheterocyclic carboxylic acid ddrivative - Google Patents

Preparation of piperazinyl benzheterocyclic carboxylic acid ddrivative

Info

Publication number
JPS55151582A
JPS55151582A JP5944379A JP5944379A JPS55151582A JP S55151582 A JPS55151582 A JP S55151582A JP 5944379 A JP5944379 A JP 5944379A JP 5944379 A JP5944379 A JP 5944379A JP S55151582 A JPS55151582 A JP S55151582A
Authority
JP
Japan
Prior art keywords
carboxylic acid
formula
lower alkyl
piperazinyl
compound shown
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5944379A
Other languages
Japanese (ja)
Other versions
JPS6037115B2 (en
Inventor
Hiroshi Ishikawa
Fujio Tafusa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP5944379A priority Critical patent/JPS6037115B2/en
Publication of JPS55151582A publication Critical patent/JPS55151582A/en
Publication of JPS6037115B2 publication Critical patent/JPS6037115B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A piperazinylbenzheterocyclic carboxylic acid derivative shown by the formula I (R<1> is H or lower alkyl; R<2> is H, lower alkyl, benzoyl, etc.; R<3> is H or halogen; n is 1 or 2) and its salt. EXAMPLE:8-( 1-Piperazinyl )-5-methyl-6,7-dihydro-1-oxo-1H,5H-benz[ ij ]quinolizine-2-carboxylic acid. USE:Antibacterial agents. Having an activity against a Gram-positive and a Gram- negative bacteria, especially against bacteria of the genus Streptococcus, Pseudomonas, etc. PROCESS:A novel compound shown by the formula II (R<4> and R<5> are H or lower alkyl) is reacted with a tertiary nitrogen atom-containing aromatic heterocyclic compound, e.g., pyridine, picoline, etc. or a trialkylamine, e.g., trimethyl-amine and an anion donor compound, e.g., chlorine, sulfuric acid, etc. to give a compound shown by the formula III (Y<+> is trialkyl ammonium, etc.; Z<-> is an anion), which is hydrolyzed to prepare a compound shown by the formula I.
JP5944379A 1979-05-15 1979-05-15 Method for producing piperazinyl benzoheterocyclic carboxylic acid derivatives Expired JPS6037115B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5944379A JPS6037115B2 (en) 1979-05-15 1979-05-15 Method for producing piperazinyl benzoheterocyclic carboxylic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5944379A JPS6037115B2 (en) 1979-05-15 1979-05-15 Method for producing piperazinyl benzoheterocyclic carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
JPS55151582A true JPS55151582A (en) 1980-11-26
JPS6037115B2 JPS6037115B2 (en) 1985-08-24

Family

ID=13113428

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5944379A Expired JPS6037115B2 (en) 1979-05-15 1979-05-15 Method for producing piperazinyl benzoheterocyclic carboxylic acid derivatives

Country Status (1)

Country Link
JP (1) JPS6037115B2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63141515U (en) * 1987-03-08 1988-09-19

Also Published As

Publication number Publication date
JPS6037115B2 (en) 1985-08-24

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