IE33535L - Penicillins - Google Patents
PenicillinsInfo
- Publication number
- IE33535L IE33535L IE690792A IE79269A IE33535L IE 33535 L IE33535 L IE 33535L IE 690792 A IE690792 A IE 690792A IE 79269 A IE79269 A IE 79269A IE 33535 L IE33535 L IE 33535L
- Authority
- IE
- Ireland
- Prior art keywords
- substituted
- formula
- cycloaliphatic
- radical
- penicillins
- Prior art date
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 4
- 150000002960 penicillins Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 sulphonyl-ureido penicillins Chemical class 0.000 abstract 2
- KNIUHBNRWZGIQQ-UHFFFAOYSA-N 7-diethoxyphosphinothioyloxy-4-methylchromen-2-one Chemical compound CC1=CC(=O)OC2=CC(OP(=S)(OCC)OCC)=CC=C21 KNIUHBNRWZGIQQ-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,260,882. Penicillins. FARBENFABRIKEN BAYER A.G. 6 June, 1969 [12 June, 1968], No. 28715/69. Heading C2A. Novel carboxyl- or sulphonyl-ureido penicillins of Formula (I) and their non-toxic salts, wherein R 1 is a carboxylic or sulphonic acid acyl radical having up to 26 carbon atoms and R 2 and R 3 are the same or different and are hydrogen, alkyl which may be substituted or interrupted by hetero atoms, or optionally substituted cycloaliphatic, araliphatic, aromatic or heterocyclic radicals, or together form a cycloaliphatic or heterocyclic ring with 3 to 7 ring members which ring may be substituted or fused to other rings, are prepared by reacting a compound of Formula (II) wherein the amino and/or carboxyl groups may be protected with silyl groups, with an acyl isocyanate (V) or an N-acylcarbamic acid derivative (VI) or (VII) wherein R 1 is as above; X is halogen, -SO 3 Na, -SO 3 K, -SO 3 NH 4 , A is -O- or -S- and R 7 is an alkyl, aralkyl or cycloaliphatic radical which may be substituted or interrupted by hetero atoms, or an optionally substituted aryl or heterocyclic radical. Pharmaceutical compositions having antibiotic activity against gram-positive and gramnegative bacteria comprise a penicillin of Formula I as defined above or a non-toxic salt thereof in admixture with a pharmaceutical diluent or carrier, or in unit dosage form with or without such a diluent or carrier.
[GB1260882A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681770620 DE1770620A1 (en) | 1968-06-12 | 1968-06-12 | New penicillins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33535L true IE33535L (en) | 1969-12-12 |
| IE33535B1 IE33535B1 (en) | 1974-08-07 |
Family
ID=5700576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE792/69A IE33535B1 (en) | 1968-06-12 | 1969-06-10 | New penicillins |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT287199B (en) |
| BE (1) | BE734455A (en) |
| BR (1) | BR6909698D0 (en) |
| CH (1) | CH525238A (en) |
| CS (1) | CS163737B2 (en) |
| DE (1) | DE1770620A1 (en) |
| ES (1) | ES368248A1 (en) |
| FR (1) | FR2010786A1 (en) |
| GB (1) | GB1260882A (en) |
| IE (1) | IE33535B1 (en) |
| IL (1) | IL32288A (en) |
| NL (1) | NL6908909A (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3933795A (en) * | 1970-05-25 | 1976-01-20 | Hans-Bodo Konig | Ureidoacetamido-penicillins |
| US4016282A (en) * | 1970-05-25 | 1977-04-05 | Bayer Aktiengesellschaft | Ureidoacetamido-penicillins |
| US3939149A (en) * | 1970-05-25 | 1976-02-17 | Bayer Aktiengesellschaft | Ureidoacetamido-penicillins |
| US3959258A (en) * | 1970-05-25 | 1976-05-25 | Bayer Aktiengesellschaft | Ureidoacetamido-penicillins |
| DE2104579C3 (en) * | 1971-02-01 | 1981-07-09 | Bayer Ag, 5090 Leverkusen | Cyclic acylureidopenicillins and medicinal products containing them |
| US3980792A (en) * | 1970-05-25 | 1976-09-14 | Bayer Aktiengesellschaft | Ureidoacetamido-penicillins |
| DE2104580C3 (en) * | 1971-02-01 | 1981-04-02 | Bayer Ag, 5090 Leverkusen | Acylureidopenicillins |
| BE790440A (en) * | 1971-10-23 | 1973-04-24 | Bayer Ag | |
| DE2320039C3 (en) * | 1973-04-19 | 1981-04-23 | Bayer Ag, 5090 Leverkusen | Penicillins and their use as medicines |
| IL47168A (en) * | 1974-05-09 | 1979-07-25 | Toyama Chemical Co Ltd | Mono or dioxo piperazino(thio)carbonylamino derivatives ofpenicillins and cephalosporins and process for producing the same |
| DE2457464A1 (en) * | 1974-12-05 | 1976-06-10 | Hoechst Ag | ACYLAMINOPENICILLANIC ACIDS AND THE METHOD FOR THEIR PRODUCTION |
| US4229348A (en) * | 1978-05-26 | 1980-10-21 | Chugai Seiyaku Kabushiki Kaisha | Penicillanic acid derivatives |
| JPS5732289A (en) | 1980-08-05 | 1982-02-20 | Chugai Pharmaceut Co Ltd | Alpha-substituted ureidobenzylpenicillin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1061335A (en) * | 1965-02-16 | 1967-03-08 | Beecham Group Ltd | Penicillins |
-
1968
- 1968-06-12 DE DE19681770620 patent/DE1770620A1/en active Pending
-
1969
- 1969-05-22 CH CH784069A patent/CH525238A/en not_active IP Right Cessation
- 1969-05-26 IL IL32288A patent/IL32288A/en unknown
- 1969-05-29 AT AT509669A patent/AT287199B/en not_active IP Right Cessation
- 1969-06-06 GB GB28715/69A patent/GB1260882A/en not_active Expired
- 1969-06-10 IE IE792/69A patent/IE33535B1/en unknown
- 1969-06-11 NL NL6908909A patent/NL6908909A/xx unknown
- 1969-06-11 ES ES368248A patent/ES368248A1/en not_active Expired
- 1969-06-12 BR BR209698/69A patent/BR6909698D0/en unknown
- 1969-06-12 BE BE734455D patent/BE734455A/xx unknown
- 1969-06-12 CS CS4168*BA patent/CS163737B2/cs unknown
- 1969-06-12 FR FR6919578A patent/FR2010786A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IE33535B1 (en) | 1974-08-07 |
| CH525238A (en) | 1972-07-15 |
| BE734455A (en) | 1969-12-12 |
| DE1770620A1 (en) | 1971-11-11 |
| IL32288A0 (en) | 1969-07-30 |
| FR2010786A1 (en) | 1970-02-20 |
| NL6908909A (en) | 1969-12-16 |
| CS163737B2 (en) | 1975-11-07 |
| GB1260882A (en) | 1972-01-19 |
| ES368248A1 (en) | 1971-05-01 |
| IL32288A (en) | 1973-08-29 |
| AT287199B (en) | 1971-01-11 |
| BR6909698D0 (en) | 1973-02-08 |
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