JPS6426581A - Cephalosporin compound and production thereof - Google Patents

Cephalosporin compound and production thereof

Info

Publication number
JPS6426581A
JPS6426581A JP62182802A JP18280287A JPS6426581A JP S6426581 A JPS6426581 A JP S6426581A JP 62182802 A JP62182802 A JP 62182802A JP 18280287 A JP18280287 A JP 18280287A JP S6426581 A JPS6426581 A JP S6426581A
Authority
JP
Japan
Prior art keywords
formula
thiomethyl
thiadiazol
ester
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62182802A
Other languages
Japanese (ja)
Inventor
Susumu Nishizawa
Hiroyuki Muro
Masayasu Kasai
Satoru Hatano
Naoharu Kamiya
Senji Kakeya
Kazuhiko Kitao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto Pharmaceutical Industries Ltd
Original Assignee
Kyoto Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharmaceutical Industries Ltd filed Critical Kyoto Pharmaceutical Industries Ltd
Priority to JP62182802A priority Critical patent/JPS6426581A/en
Priority to DK401088A priority patent/DK401088A/en
Priority to EP19880111597 priority patent/EP0300423A3/en
Priority to KR1019880009117A priority patent/KR890002183A/en
Publication of JPS6426581A publication Critical patent/JPS6426581A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:7-D-(-)-Mandelamide-3-( 1, 2, 4-thiadiazol-5-yl ) thiomethyl-3-ce phem-4-carboxylic acid expressed by formula I, ester or salt thereof. USE:An antibacterial agent for Gram-positive bacteria, especially sensitive staphylococci and resistant staphylococci. PREPARATION:A 7-amino-3-(1,2,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carb-oxy lic acid compound expressed by formula II, ester or salt thereof is acylated with a compound expressed by formula III (R represents H or OH-protecting group) [example; D-(-)-O-formylmadelic chloride]. Reaction is preferably carried out in an inert solvent (example; dichloromethane) at <=50 deg.C in the presence of a condensing agent (example; N,N-dicyclohexylcarbodiimide).
JP62182802A 1987-07-21 1987-07-21 Cephalosporin compound and production thereof Pending JPS6426581A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP62182802A JPS6426581A (en) 1987-07-21 1987-07-21 Cephalosporin compound and production thereof
DK401088A DK401088A (en) 1987-07-21 1988-07-18 CEPHALOSPOR CONNECTION, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATION CONTAINING IT
EP19880111597 EP0300423A3 (en) 1987-07-21 1988-07-19 Cephalosporin compound, method of its production and composition for prevention and treatment of bacterial infectious diseases
KR1019880009117A KR890002183A (en) 1987-07-21 1988-07-21 Cephalosporin compound, preparation method thereof, and composition for preventing and treating bacterial infection disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62182802A JPS6426581A (en) 1987-07-21 1987-07-21 Cephalosporin compound and production thereof

Publications (1)

Publication Number Publication Date
JPS6426581A true JPS6426581A (en) 1989-01-27

Family

ID=16124678

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62182802A Pending JPS6426581A (en) 1987-07-21 1987-07-21 Cephalosporin compound and production thereof

Country Status (1)

Country Link
JP (1) JPS6426581A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009018725A (en) * 2007-07-12 2009-01-29 Honda Motor Co Ltd Vehicle body frame structure
US8585133B2 (en) 2007-07-12 2013-11-19 Honda Motor Co., Ltd. Vehicle body frame structure
US8668248B2 (en) 2009-11-05 2014-03-11 Honda Motor Co., Ltd. Vehicle body structure

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009018725A (en) * 2007-07-12 2009-01-29 Honda Motor Co Ltd Vehicle body frame structure
US8585133B2 (en) 2007-07-12 2013-11-19 Honda Motor Co., Ltd. Vehicle body frame structure
US8668248B2 (en) 2009-11-05 2014-03-11 Honda Motor Co., Ltd. Vehicle body structure

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