JPS56135488A - Novel preparative method of cephalosporanic acid derivative - Google Patents
Novel preparative method of cephalosporanic acid derivativeInfo
- Publication number
- JPS56135488A JPS56135488A JP3749980A JP3749980A JPS56135488A JP S56135488 A JPS56135488 A JP S56135488A JP 3749980 A JP3749980 A JP 3749980A JP 3749980 A JP3749980 A JP 3749980A JP S56135488 A JPS56135488 A JP S56135488A
- Authority
- JP
- Japan
- Prior art keywords
- acid derivative
- formula
- novel
- cephalosporanic acid
- thiazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: A 7-aminocephalosporanic acid derivative is made to react with a novel active ester to safely produce the titled derivative used as an antibiotic agent against grampositive and -negative bacteria in high yield.
CONSTITUTION: The reaction between a 7-aminocephalosporanic acid derivative of formula I (R1 is halogen, azide, benzimidazole) and 2-amino-1,3-thiazol-4-yl-acetic 1-dimethylaminoethyl-tetrazol-5-yl thiol ester is conducted, preferably at a molar ratio of 1:(1W2) in a solvent of DMF at 40W80°C to give the objective cephalosporanic acid derivative or its salt of formula III. The compound of formula II is novel and obtained, e.g., by reaction of 1-dimethylaminoethyl-tetrazole-5-thiol of formula IV with 2-amino-1,3-thiazol-4-ylacetic acid in a solvent at -50W+100°C.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3749980A JPS56135488A (en) | 1980-03-26 | 1980-03-26 | Novel preparative method of cephalosporanic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3749980A JPS56135488A (en) | 1980-03-26 | 1980-03-26 | Novel preparative method of cephalosporanic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56135488A true JPS56135488A (en) | 1981-10-22 |
Family
ID=12499209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3749980A Pending JPS56135488A (en) | 1980-03-26 | 1980-03-26 | Novel preparative method of cephalosporanic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56135488A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6064986A (en) * | 1983-09-20 | 1985-04-13 | Toyama Chem Co Ltd | Production of cephalosporin |
CN107488185A (en) * | 2016-06-13 | 2017-12-19 | 重庆圣华曦药业股份有限公司 | A kind of new synthetic method of cefotiam hydrochloride and the application in its sterile powder injection |
-
1980
- 1980-03-26 JP JP3749980A patent/JPS56135488A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6064986A (en) * | 1983-09-20 | 1985-04-13 | Toyama Chem Co Ltd | Production of cephalosporin |
JPH0320397B2 (en) * | 1983-09-20 | 1991-03-19 | Toyama Chemical Co Ltd | |
CN107488185A (en) * | 2016-06-13 | 2017-12-19 | 重庆圣华曦药业股份有限公司 | A kind of new synthetic method of cefotiam hydrochloride and the application in its sterile powder injection |
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