JPS56135488A - Novel preparative method of cephalosporanic acid derivative - Google Patents

Novel preparative method of cephalosporanic acid derivative

Info

Publication number
JPS56135488A
JPS56135488A JP3749980A JP3749980A JPS56135488A JP S56135488 A JPS56135488 A JP S56135488A JP 3749980 A JP3749980 A JP 3749980A JP 3749980 A JP3749980 A JP 3749980A JP S56135488 A JPS56135488 A JP S56135488A
Authority
JP
Japan
Prior art keywords
acid derivative
formula
novel
cephalosporanic acid
thiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3749980A
Other languages
Japanese (ja)
Inventor
Masahiro Murakami
Masateru Kobayashi
Kimiyo Yamamoto
Kazuyuki Shibuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP3749980A priority Critical patent/JPS56135488A/en
Publication of JPS56135488A publication Critical patent/JPS56135488A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: A 7-aminocephalosporanic acid derivative is made to react with a novel active ester to safely produce the titled derivative used as an antibiotic agent against grampositive and -negative bacteria in high yield.
CONSTITUTION: The reaction between a 7-aminocephalosporanic acid derivative of formula I (R1 is halogen, azide, benzimidazole) and 2-amino-1,3-thiazol-4-yl-acetic 1-dimethylaminoethyl-tetrazol-5-yl thiol ester is conducted, preferably at a molar ratio of 1:(1W2) in a solvent of DMF at 40W80°C to give the objective cephalosporanic acid derivative or its salt of formula III. The compound of formula II is novel and obtained, e.g., by reaction of 1-dimethylaminoethyl-tetrazole-5-thiol of formula IV with 2-amino-1,3-thiazol-4-ylacetic acid in a solvent at -50W+100°C.
COPYRIGHT: (C)1981,JPO&Japio
JP3749980A 1980-03-26 1980-03-26 Novel preparative method of cephalosporanic acid derivative Pending JPS56135488A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3749980A JPS56135488A (en) 1980-03-26 1980-03-26 Novel preparative method of cephalosporanic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3749980A JPS56135488A (en) 1980-03-26 1980-03-26 Novel preparative method of cephalosporanic acid derivative

Publications (1)

Publication Number Publication Date
JPS56135488A true JPS56135488A (en) 1981-10-22

Family

ID=12499209

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3749980A Pending JPS56135488A (en) 1980-03-26 1980-03-26 Novel preparative method of cephalosporanic acid derivative

Country Status (1)

Country Link
JP (1) JPS56135488A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6064986A (en) * 1983-09-20 1985-04-13 Toyama Chem Co Ltd Production of cephalosporin
CN107488185A (en) * 2016-06-13 2017-12-19 重庆圣华曦药业股份有限公司 A kind of new synthetic method of cefotiam hydrochloride and the application in its sterile powder injection

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6064986A (en) * 1983-09-20 1985-04-13 Toyama Chem Co Ltd Production of cephalosporin
JPH0320397B2 (en) * 1983-09-20 1991-03-19 Toyama Chemical Co Ltd
CN107488185A (en) * 2016-06-13 2017-12-19 重庆圣华曦药业股份有限公司 A kind of new synthetic method of cefotiam hydrochloride and the application in its sterile powder injection

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