JPS56135489A - Preparative method of cephalosporanic acid derivative - Google Patents
Preparative method of cephalosporanic acid derivativeInfo
- Publication number
- JPS56135489A JPS56135489A JP3750180A JP3750180A JPS56135489A JP S56135489 A JPS56135489 A JP S56135489A JP 3750180 A JP3750180 A JP 3750180A JP 3750180 A JP3750180 A JP 3750180A JP S56135489 A JPS56135489 A JP S56135489A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- acid derivative
- formula
- cephalosporanic acid
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: A 7-aminocephalosporanic acid derivative is made to react with a novel active ester to safely produce the titled derivative used as antibiotic against grampositive and -negative bacteria in high yield.
CONSTITUTION: The reaction between a 7-aminocephalosporanic acid derivative or its salt of formula I (R is halogen, azide, acetoxy) and mandelic pyridine-N-oxide- 2-yl thiol ester is conducted, preferably at a molar ratio of 1:(1W2) in a solvent of DMF at 40°W80°C to produce the objective cephalosporanic acid derivative of formula III. The compound of formula II is novel and obtained, e.g., by reaction of pyridine-N-oxide-2-thiol of formula IV or its derivative with madelic acid or its derivative in a solvent at -50°W+100°C.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3750180A JPS56135489A (en) | 1980-03-26 | 1980-03-26 | Preparative method of cephalosporanic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3750180A JPS56135489A (en) | 1980-03-26 | 1980-03-26 | Preparative method of cephalosporanic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56135489A true JPS56135489A (en) | 1981-10-22 |
Family
ID=12499266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3750180A Pending JPS56135489A (en) | 1980-03-26 | 1980-03-26 | Preparative method of cephalosporanic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56135489A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210371192A1 (en) * | 2018-10-02 | 2021-12-02 | Jung Han CHAE | Ice cream packaging material using horizontal disposable plastic film mold as inner packaging material |
-
1980
- 1980-03-26 JP JP3750180A patent/JPS56135489A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210371192A1 (en) * | 2018-10-02 | 2021-12-02 | Jung Han CHAE | Ice cream packaging material using horizontal disposable plastic film mold as inner packaging material |
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