JPS5653684A - Production of cephalosporin derivative - Google Patents
Production of cephalosporin derivativeInfo
- Publication number
- JPS5653684A JPS5653684A JP12927579A JP12927579A JPS5653684A JP S5653684 A JPS5653684 A JP S5653684A JP 12927579 A JP12927579 A JP 12927579A JP 12927579 A JP12927579 A JP 12927579A JP S5653684 A JPS5653684 A JP S5653684A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- acid
- tetrazol
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: A cephem derivative is made to react with a thiol of thiadiazole to produce the titled compound that has strong bactericidal activity against a wide range of microorganisms safely and effectively in high yield.
CONSTITUTION: The reaction of 7-(1H-tetrazol-1-ylacetamide)-3-(benzimidazol-2- yl)thiomethyl-3-cephem-4-carboxylic acid or its salt with a compound of formula II (R is H, methyl) is conducted in a solvent such as N,N-dimethylformamide, preferably in the presence of an acid catalyst such as hydrochloric acid or sulfuric aicd to give a compound of formula III or its salt. The starting material, the compound of formula I, is obtained by the reaction of 7-(1H-tetrazol-1-yl-acetamide) cephalosporanic acid with 2-mercatobenzimidazole.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12927579A JPS5923316B2 (en) | 1979-10-06 | 1979-10-06 | Method for producing cephalosporin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12927579A JPS5923316B2 (en) | 1979-10-06 | 1979-10-06 | Method for producing cephalosporin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5653684A true JPS5653684A (en) | 1981-05-13 |
JPS5923316B2 JPS5923316B2 (en) | 1984-06-01 |
Family
ID=15005553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12927579A Expired JPS5923316B2 (en) | 1979-10-06 | 1979-10-06 | Method for producing cephalosporin derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5923316B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102617606A (en) * | 2012-03-31 | 2012-08-01 | 哈药集团制药总厂 | Method for preparing ceftezole sodium compound |
-
1979
- 1979-10-06 JP JP12927579A patent/JPS5923316B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102617606A (en) * | 2012-03-31 | 2012-08-01 | 哈药集团制药总厂 | Method for preparing ceftezole sodium compound |
Also Published As
Publication number | Publication date |
---|---|
JPS5923316B2 (en) | 1984-06-01 |
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