JPS5653684A - Production of cephalosporin derivative - Google Patents

Production of cephalosporin derivative

Info

Publication number
JPS5653684A
JPS5653684A JP12927579A JP12927579A JPS5653684A JP S5653684 A JPS5653684 A JP S5653684A JP 12927579 A JP12927579 A JP 12927579A JP 12927579 A JP12927579 A JP 12927579A JP S5653684 A JPS5653684 A JP S5653684A
Authority
JP
Japan
Prior art keywords
compound
formula
acid
tetrazol
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12927579A
Other languages
Japanese (ja)
Other versions
JPS5923316B2 (en
Inventor
Masahiro Murakami
Masateru Kobayashi
Takanori Sone
Kazuyuki Shibuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP12927579A priority Critical patent/JPS5923316B2/en
Publication of JPS5653684A publication Critical patent/JPS5653684A/en
Publication of JPS5923316B2 publication Critical patent/JPS5923316B2/en
Expired legal-status Critical Current

Links

Abstract

PURPOSE: A cephem derivative is made to react with a thiol of thiadiazole to produce the titled compound that has strong bactericidal activity against a wide range of microorganisms safely and effectively in high yield.
CONSTITUTION: The reaction of 7-(1H-tetrazol-1-ylacetamide)-3-(benzimidazol-2- yl)thiomethyl-3-cephem-4-carboxylic acid or its salt with a compound of formula II (R is H, methyl) is conducted in a solvent such as N,N-dimethylformamide, preferably in the presence of an acid catalyst such as hydrochloric acid or sulfuric aicd to give a compound of formula III or its salt. The starting material, the compound of formula I, is obtained by the reaction of 7-(1H-tetrazol-1-yl-acetamide) cephalosporanic acid with 2-mercatobenzimidazole.
COPYRIGHT: (C)1981,JPO&Japio
JP12927579A 1979-10-06 1979-10-06 Method for producing cephalosporin derivatives Expired JPS5923316B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12927579A JPS5923316B2 (en) 1979-10-06 1979-10-06 Method for producing cephalosporin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12927579A JPS5923316B2 (en) 1979-10-06 1979-10-06 Method for producing cephalosporin derivatives

Publications (2)

Publication Number Publication Date
JPS5653684A true JPS5653684A (en) 1981-05-13
JPS5923316B2 JPS5923316B2 (en) 1984-06-01

Family

ID=15005553

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12927579A Expired JPS5923316B2 (en) 1979-10-06 1979-10-06 Method for producing cephalosporin derivatives

Country Status (1)

Country Link
JP (1) JPS5923316B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102617606A (en) * 2012-03-31 2012-08-01 哈药集团制药总厂 Method for preparing ceftezole sodium compound

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102617606A (en) * 2012-03-31 2012-08-01 哈药集团制药总厂 Method for preparing ceftezole sodium compound

Also Published As

Publication number Publication date
JPS5923316B2 (en) 1984-06-01

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