JPS5748986A - Production of cephalosporanic acid - Google Patents
Production of cephalosporanic acidInfo
- Publication number
- JPS5748986A JPS5748986A JP12347580A JP12347580A JPS5748986A JP S5748986 A JPS5748986 A JP S5748986A JP 12347580 A JP12347580 A JP 12347580A JP 12347580 A JP12347580 A JP 12347580A JP S5748986 A JPS5748986 A JP S5748986A
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- formula
- diazin
- aminocephalosporanic
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: The reaction of 7-aminocephalosporanic derivative with 3-hydroxy-1,2- diazin-6-ylthiol mandelate gives the titled compound used as an antibiotic in high safety and high yield.
CONSTITUTION: A 7-aminocephalosporanic derivative of formula I (R1 is halogen, azide, acetoxy, banzimidazolthio) such as 7-amino-3-(benzimidazol-2-yl)thiomethyl- 3-cephem-4-carboxylic acid is heated in dimethylformamide and water and 3-hydroxy-1,2-diazin-6-yl-thiol madelate of formula II and dilute hydrochloric acid as a reaction catalyst are added to the mixture to effect the reaction, thus producing objective compound of formula III.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12347580A JPS5748986A (en) | 1980-09-08 | 1980-09-08 | Production of cephalosporanic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12347580A JPS5748986A (en) | 1980-09-08 | 1980-09-08 | Production of cephalosporanic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5748986A true JPS5748986A (en) | 1982-03-20 |
Family
ID=14861541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12347580A Pending JPS5748986A (en) | 1980-09-08 | 1980-09-08 | Production of cephalosporanic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5748986A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU587974B2 (en) * | 1984-03-29 | 1989-09-07 | Biochemie Gesellschaft Mbh | Process for preparation of cephalosporins |
-
1980
- 1980-09-08 JP JP12347580A patent/JPS5748986A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU587974B2 (en) * | 1984-03-29 | 1989-09-07 | Biochemie Gesellschaft Mbh | Process for preparation of cephalosporins |
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