JPS5527111A - Preparation of cephapirin - Google Patents

Preparation of cephapirin

Info

Publication number
JPS5527111A
JPS5527111A JP9831678A JP9831678A JPS5527111A JP S5527111 A JPS5527111 A JP S5527111A JP 9831678 A JP9831678 A JP 9831678A JP 9831678 A JP9831678 A JP 9831678A JP S5527111 A JPS5527111 A JP S5527111A
Authority
JP
Japan
Prior art keywords
acid
cephapirin
mercaptopyridine
salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9831678A
Other languages
Japanese (ja)
Inventor
Tetsuaki Miyazaki
Hisao Tohiki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP9831678A priority Critical patent/JPS5527111A/en
Publication of JPS5527111A publication Critical patent/JPS5527111A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To prepare the high-quality title compound, easily in high yield, by reacting a compound obtained from sulfonylglycolic acid and 7-aminocephalosporanic acid, with 4-mercaptopyridine in a short time.
CONSTITUTION: Sulfonylglycolic acid of formula I (R is aryl or alkyl) or its reactive derivative in the carboxyl group, e.g. an acid halide, an acid azide, etc., and 7-aminocephalosporanic acid or its salt are reacted together. Subsequently, the obtained compound of formula II is reacted, with or without isolation, with 4- mercaptopyridine or its salt in mercapto group, in a solvent, preferably in the presence of an organic base. 7-[2-(4-Pyridylthio)acetoamide]cephalosporanic acid (=cephapirin) or non-toxic salts are obtained the yield of as high as 80W90%.
COPYRIGHT: (C)1980,JPO&Japio
JP9831678A 1978-08-11 1978-08-11 Preparation of cephapirin Pending JPS5527111A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9831678A JPS5527111A (en) 1978-08-11 1978-08-11 Preparation of cephapirin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9831678A JPS5527111A (en) 1978-08-11 1978-08-11 Preparation of cephapirin

Publications (1)

Publication Number Publication Date
JPS5527111A true JPS5527111A (en) 1980-02-27

Family

ID=14216506

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9831678A Pending JPS5527111A (en) 1978-08-11 1978-08-11 Preparation of cephapirin

Country Status (1)

Country Link
JP (1) JPS5527111A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104211718A (en) * 2013-06-03 2014-12-17 浙江尖峰药业有限公司 Cephapirin sodium A type crystal compound and preparation method thereof
CN104211719A (en) * 2013-06-03 2014-12-17 浙江尖峰药业有限公司 Cephapirin sodium compound and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104211718A (en) * 2013-06-03 2014-12-17 浙江尖峰药业有限公司 Cephapirin sodium A type crystal compound and preparation method thereof
CN104211719A (en) * 2013-06-03 2014-12-17 浙江尖峰药业有限公司 Cephapirin sodium compound and preparation method thereof

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