JPS554346A - Preparation of cephapirin sodium - Google Patents

Preparation of cephapirin sodium

Info

Publication number
JPS554346A
JPS554346A JP7726078A JP7726078A JPS554346A JP S554346 A JPS554346 A JP S554346A JP 7726078 A JP7726078 A JP 7726078A JP 7726078 A JP7726078 A JP 7726078A JP S554346 A JPS554346 A JP S554346A
Authority
JP
Japan
Prior art keywords
aca
reaction
pyridylthioacetyl
moles
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7726078A
Other languages
Japanese (ja)
Inventor
Kenichi Ishibashi
Reiko Komaki
Shun Ishiguro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TOSHIN CHEM KK
Original Assignee
TOSHIN CHEM KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TOSHIN CHEM KK filed Critical TOSHIN CHEM KK
Priority to JP7726078A priority Critical patent/JPS554346A/en
Publication of JPS554346A publication Critical patent/JPS554346A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To obtain the title compound useful as an antibacterial, in high purity and yield, by reacting a product of reaction between 7-aminocephalosporanic acid (7-ACA) silylated with a specific agent with a 4-pyridylthioacetyl chloride hydrochloride, and by hydrolyzing and changing the reaction product into a salt.
CONSTITUTION: One mole of 7-ACA is reacted with 1.0W1.5 moles of an N,N- bistrimethylsilylacetamide to form a trimethylsilyl derivative of 7-ACA, which is reacted with 1.10W1.45 moles of 4-pyridylthioacetyl chloride hydrochloride, hydrolyzed, and changed into a sodium salt to give cephapirin sodium. The reaction is carried out in an anhydrous organic solvent, preferably methylene chloride.
COPYRIGHT: (C)1980,JPO&Japio
JP7726078A 1978-06-26 1978-06-26 Preparation of cephapirin sodium Pending JPS554346A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7726078A JPS554346A (en) 1978-06-26 1978-06-26 Preparation of cephapirin sodium

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7726078A JPS554346A (en) 1978-06-26 1978-06-26 Preparation of cephapirin sodium

Publications (1)

Publication Number Publication Date
JPS554346A true JPS554346A (en) 1980-01-12

Family

ID=13628873

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7726078A Pending JPS554346A (en) 1978-06-26 1978-06-26 Preparation of cephapirin sodium

Country Status (1)

Country Link
JP (1) JPS554346A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104211719A (en) * 2013-06-03 2014-12-17 浙江尖峰药业有限公司 Cephapirin sodium compound and preparation method thereof
CN104211718A (en) * 2013-06-03 2014-12-17 浙江尖峰药业有限公司 Cephapirin sodium A type crystal compound and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104211719A (en) * 2013-06-03 2014-12-17 浙江尖峰药业有限公司 Cephapirin sodium compound and preparation method thereof
CN104211718A (en) * 2013-06-03 2014-12-17 浙江尖峰药业有限公司 Cephapirin sodium A type crystal compound and preparation method thereof

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