JPS5651487A - Preparation of alpha-substituted benzylpenicillin salt - Google Patents

Preparation of alpha-substituted benzylpenicillin salt

Info

Publication number
JPS5651487A
JPS5651487A JP12706179A JP12706179A JPS5651487A JP S5651487 A JPS5651487 A JP S5651487A JP 12706179 A JP12706179 A JP 12706179A JP 12706179 A JP12706179 A JP 12706179A JP S5651487 A JPS5651487 A JP S5651487A
Authority
JP
Japan
Prior art keywords
formula
substituted
aminopenicillanate
reacted
active ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12706179A
Other languages
Japanese (ja)
Inventor
Kenichi Ishibashi
Shun Ishiguro
Reiko Komaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TOSHIN CHEM KK
TOUSHIN CHEMICAL KK
Original Assignee
TOSHIN CHEM KK
TOUSHIN CHEMICAL KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TOSHIN CHEM KK, TOUSHIN CHEMICAL KK filed Critical TOSHIN CHEM KK
Priority to JP12706179A priority Critical patent/JPS5651487A/en
Publication of JPS5651487A publication Critical patent/JPS5651487A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain titled compound useful for infectious diseases in urinary tracts due to Pseudomonas aeruginosa, etc., by reacting a specific active ester compound as a reactant with a 6-aminopenicillanate.
CONSTITUTION: A dimethylaminohalogensmethyleneammonium halide of formula I (X and X' are halogens) is reacted with a monoester of a phenylalonic acid expressed by formula II (R is phenyl, etc.) to give an active ester of formula III, which is then reacted with a 6-aminopenicillanate to afford an α-substituted benzylpenicillin salt of formula IV (Me is monovalent alkali metal or alkaline earth metal).
EFFECT: The reaction can be carried out at a low temperature in a short time, using inexpensive raw materials. The method is industrially advantageous because of ready isolation of the aimed substance from the reaction mixture with little by-products.
COPYRIGHT: (C)1981,JPO&Japio
JP12706179A 1979-10-02 1979-10-02 Preparation of alpha-substituted benzylpenicillin salt Pending JPS5651487A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12706179A JPS5651487A (en) 1979-10-02 1979-10-02 Preparation of alpha-substituted benzylpenicillin salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12706179A JPS5651487A (en) 1979-10-02 1979-10-02 Preparation of alpha-substituted benzylpenicillin salt

Publications (1)

Publication Number Publication Date
JPS5651487A true JPS5651487A (en) 1981-05-09

Family

ID=14950615

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12706179A Pending JPS5651487A (en) 1979-10-02 1979-10-02 Preparation of alpha-substituted benzylpenicillin salt

Country Status (1)

Country Link
JP (1) JPS5651487A (en)

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