JPS5592343A - Preparation of optically active substituted isovaleric acid - Google Patents
Preparation of optically active substituted isovaleric acidInfo
- Publication number
- JPS5592343A JPS5592343A JP89379A JP89379A JPS5592343A JP S5592343 A JPS5592343 A JP S5592343A JP 89379 A JP89379 A JP 89379A JP 89379 A JP89379 A JP 89379A JP S5592343 A JPS5592343 A JP S5592343A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- isovaleric acid
- optically active
- organic solvent
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the title isovaleric acid derivative having excellent insecticidal activity as the acid component of a pyrethroid insecticide and having a high optical purity, by reacting a substituted isovaleric acid with an optically active organic base, and resolving the products taking advantage of the solubility difference.
CONSTITUTION: A substituted isovaleric acid I (R is 1W6C lower alkyl), e.g. (±)- α-isobutoxyisovaleric acid, etc., is reacted with (-)-isomer of an optically active organic base II (R1 and R2 are H or lower alkyl), e.g. (-)-α-benzyl-p-methylbenzylamine, etc., to give the salt. The crystal of the (-)-amine salt of the (+)- substituted isovaleric acid is obtained from the salt by using an organic solvent, e.g. benzene, ethyl acetate, etc. The crystal is decomposed with an alkali or a strong acid and extracted with an organic solvent. The water layer is decomposed with an acid or an alkali and extracted with an organic solvent to give the optically active substituted isovaleric acid, e.g. (+)-α-isobutoxyisovaleric acid, etc.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP89379A JPS5592343A (en) | 1979-01-06 | 1979-01-06 | Preparation of optically active substituted isovaleric acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP89379A JPS5592343A (en) | 1979-01-06 | 1979-01-06 | Preparation of optically active substituted isovaleric acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5592343A true JPS5592343A (en) | 1980-07-12 |
| JPS6213337B2 JPS6213337B2 (en) | 1987-03-25 |
Family
ID=11486351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP89379A Granted JPS5592343A (en) | 1979-01-06 | 1979-01-06 | Preparation of optically active substituted isovaleric acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5592343A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5929670A (en) * | 1982-08-11 | 1984-02-16 | Sumitomo Chem Co Ltd | Separation of optically active half ester |
| US4625053A (en) * | 1984-12-28 | 1986-11-25 | Nissan Chemical Industries Ltd. | Process for preparing optically active 2-(4-hydroxy-phenoxy) propionic acid compounds |
-
1979
- 1979-01-06 JP JP89379A patent/JPS5592343A/en active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5929670A (en) * | 1982-08-11 | 1984-02-16 | Sumitomo Chem Co Ltd | Separation of optically active half ester |
| JPH0435464B2 (en) * | 1982-08-11 | 1992-06-11 | Sumitomo Chemical Co | |
| US4625053A (en) * | 1984-12-28 | 1986-11-25 | Nissan Chemical Industries Ltd. | Process for preparing optically active 2-(4-hydroxy-phenoxy) propionic acid compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6213337B2 (en) | 1987-03-25 |
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