JPS54106478A - Preparation of 1, 3-dioxane derivative - Google Patents
Preparation of 1, 3-dioxane derivativeInfo
- Publication number
- JPS54106478A JPS54106478A JP1154778A JP1154778A JPS54106478A JP S54106478 A JPS54106478 A JP S54106478A JP 1154778 A JP1154778 A JP 1154778A JP 1154778 A JP1154778 A JP 1154778A JP S54106478 A JPS54106478 A JP S54106478A
- Authority
- JP
- Japan
- Prior art keywords
- meldrum
- formula
- acid
- preparation
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
PURPOSE: To obtain the title compound useful as an intermediate for medicines and pesticides advantageously, by thermal decomposition of a specific safe nonirritating compound, obtained through acylation of Meldrum's acid in high yield at low cost.
CONSTITUTION: An 5-acyl derivative of Meldrum's acid of formula I: (R1, R2, and R3 are lower alkyl groups) or its homolog is heated at a temperature above the melting point, usually 100W120°C, for 30minW1hr. The reaction mixture is cooled to room temperature and dissolved in a suitable organic solvent, washed with an aqueous alkali, water, etc., and dried. The solvent is distilled away to give an 4-alkyl-2,2-dialkyl-1,3-dioxene-6-one of formula II.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1154778A JPS6039276B2 (en) | 1978-02-06 | 1978-02-06 | Method for producing 1,3-dioxane derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1154778A JPS6039276B2 (en) | 1978-02-06 | 1978-02-06 | Method for producing 1,3-dioxane derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54106478A true JPS54106478A (en) | 1979-08-21 |
JPS6039276B2 JPS6039276B2 (en) | 1985-09-05 |
Family
ID=11780977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1154778A Expired JPS6039276B2 (en) | 1978-02-06 | 1978-02-06 | Method for producing 1,3-dioxane derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6039276B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112174929A (en) * | 2020-10-13 | 2021-01-05 | 台州市生物医化产业研究院有限公司 | Pyrolysis impurity of sitagliptin key intermediate, and preparation method and application thereof |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61189522U (en) * | 1985-05-17 | 1986-11-26 | ||
JPS63291494A (en) * | 1987-05-25 | 1988-11-29 | Ibiden Co Ltd | Surface mounting printed wiring board |
JPS63198178U (en) * | 1987-06-11 | 1988-12-20 | ||
JPH01143083U (en) * | 1988-03-28 | 1989-09-29 |
-
1978
- 1978-02-06 JP JP1154778A patent/JPS6039276B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112174929A (en) * | 2020-10-13 | 2021-01-05 | 台州市生物医化产业研究院有限公司 | Pyrolysis impurity of sitagliptin key intermediate, and preparation method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS6039276B2 (en) | 1985-09-05 |
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