JPS5564575A - Preparation of 3-acyl-5-fluorouracil - Google Patents

Preparation of 3-acyl-5-fluorouracil

Info

Publication number
JPS5564575A
JPS5564575A JP13731278A JP13731278A JPS5564575A JP S5564575 A JPS5564575 A JP S5564575A JP 13731278 A JP13731278 A JP 13731278A JP 13731278 A JP13731278 A JP 13731278A JP S5564575 A JPS5564575 A JP S5564575A
Authority
JP
Japan
Prior art keywords
fluorouracil
acyl
acid
diacyl
excess
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13731278A
Other languages
Japanese (ja)
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Kikuo Wakizaka
Yasuo Nagamatsu
Hideo Sugi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP13731278A priority Critical patent/JPS5564575A/en
Publication of JPS5564575A publication Critical patent/JPS5564575A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title compound useful as an antitumor agent or its intermediate industrially advantageously, by treating a 1, 3-diacyl-5-fluorouracil readily obtained through acylation of 5-fluorouracil with an excess of an acylating agent.
CONSTITUTION: A 1, 3-diacyl-5-fluorouracil (F) of formula II: (R is lower alkyl, H, lower alkoxy, nitro, or halogen) is treated with an acid, e.g. acetic acid or its derivative, at room temperature to 100°C, to give an 3-acyl-5-fluorouracil of formula I without requiring troublesome treatments. F is readily obtained by reacting 5- flurouracil with an excess an acylating agent. The acid is used directly or diluted in a solvent.
COPYRIGHT: (C)1980,JPO&Japio
JP13731278A 1978-11-09 1978-11-09 Preparation of 3-acyl-5-fluorouracil Pending JPS5564575A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13731278A JPS5564575A (en) 1978-11-09 1978-11-09 Preparation of 3-acyl-5-fluorouracil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13731278A JPS5564575A (en) 1978-11-09 1978-11-09 Preparation of 3-acyl-5-fluorouracil

Publications (1)

Publication Number Publication Date
JPS5564575A true JPS5564575A (en) 1980-05-15

Family

ID=15195736

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13731278A Pending JPS5564575A (en) 1978-11-09 1978-11-09 Preparation of 3-acyl-5-fluorouracil

Country Status (1)

Country Link
JP (1) JPS5564575A (en)

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