JPS5564575A - Preparation of 3-acyl-5-fluorouracil - Google Patents
Preparation of 3-acyl-5-fluorouracilInfo
- Publication number
- JPS5564575A JPS5564575A JP13731278A JP13731278A JPS5564575A JP S5564575 A JPS5564575 A JP S5564575A JP 13731278 A JP13731278 A JP 13731278A JP 13731278 A JP13731278 A JP 13731278A JP S5564575 A JPS5564575 A JP S5564575A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouracil
- acyl
- acid
- diacyl
- excess
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title compound useful as an antitumor agent or its intermediate industrially advantageously, by treating a 1, 3-diacyl-5-fluorouracil readily obtained through acylation of 5-fluorouracil with an excess of an acylating agent.
CONSTITUTION: A 1, 3-diacyl-5-fluorouracil (F) of formula II: (R is lower alkyl, H, lower alkoxy, nitro, or halogen) is treated with an acid, e.g. acetic acid or its derivative, at room temperature to 100°C, to give an 3-acyl-5-fluorouracil of formula I without requiring troublesome treatments. F is readily obtained by reacting 5- flurouracil with an excess an acylating agent. The acid is used directly or diluted in a solvent.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13731278A JPS5564575A (en) | 1978-11-09 | 1978-11-09 | Preparation of 3-acyl-5-fluorouracil |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13731278A JPS5564575A (en) | 1978-11-09 | 1978-11-09 | Preparation of 3-acyl-5-fluorouracil |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5564575A true JPS5564575A (en) | 1980-05-15 |
Family
ID=15195736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13731278A Pending JPS5564575A (en) | 1978-11-09 | 1978-11-09 | Preparation of 3-acyl-5-fluorouracil |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5564575A (en) |
-
1978
- 1978-11-09 JP JP13731278A patent/JPS5564575A/en active Pending
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