JPS54138558A - Preparation of 5-aryl-hydantoin - Google Patents
Preparation of 5-aryl-hydantoinInfo
- Publication number
- JPS54138558A JPS54138558A JP4625378A JP4625378A JPS54138558A JP S54138558 A JPS54138558 A JP S54138558A JP 4625378 A JP4625378 A JP 4625378A JP 4625378 A JP4625378 A JP 4625378A JP S54138558 A JPS54138558 A JP S54138558A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- aryl
- alloxanic
- formula
- aryl compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title substance valuable as an intermediate for the synthesis of α-aryl-α-aminoacetic acids which are modifiers of semisynthetic penicillin efficiently, by reacting a safe inexpensive aryl compound with alloxanic acid in an acid medium.
CONSTITUTION: An aryl compound of formula I: (R1 is OH or lower alkoxy group, and the o- or p-position is unsubstituted; R2 and R3 are H, OH, alkoxy, alkyl, halogen, acylated amino, or nitro groups), e.g. an unsubstituted phenol, is reacted with alloxanic acid of formula II in an acid medium at room temperature or above, preferably 50°C W reflux temperature for 30 minWseveral hr to give the objective substance of formula III. An acetic acid-sulfuric acid mixture or 5W30% hydrochloric or sulfuric acid is preferably used as the acid medium. Alloxan is treated with an alkali to form alloxanic acid, which may be, directly without isolation, reacted with the aryl compound.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4625378A JPS54138558A (en) | 1978-04-19 | 1978-04-19 | Preparation of 5-aryl-hydantoin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4625378A JPS54138558A (en) | 1978-04-19 | 1978-04-19 | Preparation of 5-aryl-hydantoin |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54138558A true JPS54138558A (en) | 1979-10-27 |
Family
ID=12742003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4625378A Pending JPS54138558A (en) | 1978-04-19 | 1978-04-19 | Preparation of 5-aryl-hydantoin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54138558A (en) |
-
1978
- 1978-04-19 JP JP4625378A patent/JPS54138558A/en active Pending
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