JPS54138558A - Preparation of 5-aryl-hydantoin - Google Patents

Preparation of 5-aryl-hydantoin

Info

Publication number
JPS54138558A
JPS54138558A JP4625378A JP4625378A JPS54138558A JP S54138558 A JPS54138558 A JP S54138558A JP 4625378 A JP4625378 A JP 4625378A JP 4625378 A JP4625378 A JP 4625378A JP S54138558 A JPS54138558 A JP S54138558A
Authority
JP
Japan
Prior art keywords
acid
aryl
alloxanic
formula
aryl compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4625378A
Other languages
Japanese (ja)
Inventor
Arahiko Eguchi
Fusayoshi Kakizaki
Kunisuke Izawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP4625378A priority Critical patent/JPS54138558A/en
Publication of JPS54138558A publication Critical patent/JPS54138558A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title substance valuable as an intermediate for the synthesis of α-aryl-α-aminoacetic acids which are modifiers of semisynthetic penicillin efficiently, by reacting a safe inexpensive aryl compound with alloxanic acid in an acid medium.
CONSTITUTION: An aryl compound of formula I: (R1 is OH or lower alkoxy group, and the o- or p-position is unsubstituted; R2 and R3 are H, OH, alkoxy, alkyl, halogen, acylated amino, or nitro groups), e.g. an unsubstituted phenol, is reacted with alloxanic acid of formula II in an acid medium at room temperature or above, preferably 50°C W reflux temperature for 30 minWseveral hr to give the objective substance of formula III. An acetic acid-sulfuric acid mixture or 5W30% hydrochloric or sulfuric acid is preferably used as the acid medium. Alloxan is treated with an alkali to form alloxanic acid, which may be, directly without isolation, reacted with the aryl compound.
COPYRIGHT: (C)1979,JPO&Japio
JP4625378A 1978-04-19 1978-04-19 Preparation of 5-aryl-hydantoin Pending JPS54138558A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4625378A JPS54138558A (en) 1978-04-19 1978-04-19 Preparation of 5-aryl-hydantoin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4625378A JPS54138558A (en) 1978-04-19 1978-04-19 Preparation of 5-aryl-hydantoin

Publications (1)

Publication Number Publication Date
JPS54138558A true JPS54138558A (en) 1979-10-27

Family

ID=12742003

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4625378A Pending JPS54138558A (en) 1978-04-19 1978-04-19 Preparation of 5-aryl-hydantoin

Country Status (1)

Country Link
JP (1) JPS54138558A (en)

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