JPS5677266A - Synthesis of 2,3-dioxopiperazine derivative - Google Patents
Synthesis of 2,3-dioxopiperazine derivativeInfo
- Publication number
- JPS5677266A JPS5677266A JP15464079A JP15464079A JPS5677266A JP S5677266 A JPS5677266 A JP S5677266A JP 15464079 A JP15464079 A JP 15464079A JP 15464079 A JP15464079 A JP 15464079A JP S5677266 A JPS5677266 A JP S5677266A
- Authority
- JP
- Japan
- Prior art keywords
- alkali metal
- metal alcoholate
- formula
- ethylenediamine derivative
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the titled compound useful as an intermediate of pharmaceuticals, with simple process, in high yield, by reacting an ethylenediamine derivative with easily available ethyl oxalate in the presence of an alkali metal alcoholate under mild conditions.
CONSTITUTION: A compound of formula III R1 and R2 are H, alkyl or aryl which may have OH group as substituent group) is prepared by the condensation reaction of an ethylenediamine derivative of formula IX with an oxalic acid ester of formula II R3 is lower alkyl) in the presence of an alkali metal alcoholate, e.g. sodium methylate, at 20W130°C, pref. 20W70°C. The amount of the alkali metal alcoholate used in the reaction is equimolar or more based on the ethylenediamine derivative.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15464079A JPS6058914B2 (en) | 1979-11-28 | 1979-11-28 | 2. Synthesis method of 3-dioxopiperazine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15464079A JPS6058914B2 (en) | 1979-11-28 | 1979-11-28 | 2. Synthesis method of 3-dioxopiperazine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5677266A true JPS5677266A (en) | 1981-06-25 |
JPS6058914B2 JPS6058914B2 (en) | 1985-12-23 |
Family
ID=15588625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15464079A Expired JPS6058914B2 (en) | 1979-11-28 | 1979-11-28 | 2. Synthesis method of 3-dioxopiperazine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6058914B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100542820B1 (en) * | 2002-09-17 | 2006-01-20 | 이재호 | Method of Preparing 1-Ethyl-2,3-Dioxopiperazine using oxalyl chloride |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0427208U (en) * | 1990-06-27 | 1992-03-04 |
-
1979
- 1979-11-28 JP JP15464079A patent/JPS6058914B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100542820B1 (en) * | 2002-09-17 | 2006-01-20 | 이재호 | Method of Preparing 1-Ethyl-2,3-Dioxopiperazine using oxalyl chloride |
Also Published As
Publication number | Publication date |
---|---|
JPS6058914B2 (en) | 1985-12-23 |
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