JPS5798284A - Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine - Google Patents
Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthineInfo
- Publication number
- JPS5798284A JPS5798284A JP17429280A JP17429280A JPS5798284A JP S5798284 A JPS5798284 A JP S5798284A JP 17429280 A JP17429280 A JP 17429280A JP 17429280 A JP17429280 A JP 17429280A JP S5798284 A JPS5798284 A JP S5798284A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- dimethylxanthine
- reacting
- lewis acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the titled compound having vasodilating activity, in high yield and purity, by reacting 1-(3-sulfonyloxypropyl)-3,7-dimethylxanthine with acetylacetone in the presence of a Lewis acid catalyst.
CONSTITUTION: The compound of formulaIis prepared by reacting the compound of formula II[R is lower alkyl, (substituted) aryl or aralkyl]with acetylacetone of formula III in the presence of a Lewis acid catalyst (e.g. BF3, AlCl3, SO3, SiF4, etc.) in a solvent such as ethyl alcohol under heat refluxing. The amount of the Lewis acid is as low as 3W7wt% of the compound of formula II, and that of the compound of formula III is pref. 1W2mol per 1mol of the compound of formula II. The compound of formula II used as the starting material can be prepared easily by reacting 1-(3-hydroxypropyl)-3,7-dimethylxanthine with R-SO2Cl.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17429280A JPS5798284A (en) | 1980-12-10 | 1980-12-10 | Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17429280A JPS5798284A (en) | 1980-12-10 | 1980-12-10 | Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5798284A true JPS5798284A (en) | 1982-06-18 |
Family
ID=15976115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17429280A Pending JPS5798284A (en) | 1980-12-10 | 1980-12-10 | Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5798284A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60227270A (en) * | 1984-04-26 | 1985-11-12 | Fuji Elelctrochem Co Ltd | Ferrite carrier material for electrostatic copying |
| WO2011028835A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| WO2013155465A1 (en) | 2012-04-13 | 2013-10-17 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| EP2963040A1 (en) | 2009-09-02 | 2016-01-06 | Concert Pharmaceuticals Inc. | Substituted xanthine derivatives |
| EP3199203A1 (en) | 2008-02-29 | 2017-08-02 | Concert Pharmaceuticals Inc. | Substitued xanthine derivatives |
-
1980
- 1980-12-10 JP JP17429280A patent/JPS5798284A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60227270A (en) * | 1984-04-26 | 1985-11-12 | Fuji Elelctrochem Co Ltd | Ferrite carrier material for electrostatic copying |
| JPH0428304B2 (en) * | 1984-04-26 | 1992-05-14 | Fuji Electrochemical Co Ltd | |
| EP3199203A1 (en) | 2008-02-29 | 2017-08-02 | Concert Pharmaceuticals Inc. | Substitued xanthine derivatives |
| WO2011028835A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| EP2963040A1 (en) | 2009-09-02 | 2016-01-06 | Concert Pharmaceuticals Inc. | Substituted xanthine derivatives |
| WO2013155465A1 (en) | 2012-04-13 | 2013-10-17 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
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