JPS56138140A - Preparation of 2- p-halomethylphenyl propionic acid or its ester - Google Patents

Preparation of 2- p-halomethylphenyl propionic acid or its ester

Info

Publication number
JPS56138140A
JPS56138140A JP4129180A JP4129180A JPS56138140A JP S56138140 A JPS56138140 A JP S56138140A JP 4129180 A JP4129180 A JP 4129180A JP 4129180 A JP4129180 A JP 4129180A JP S56138140 A JPS56138140 A JP S56138140A
Authority
JP
Japan
Prior art keywords
condensing agent
ester
readily
propionic acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4129180A
Other languages
Japanese (ja)
Other versions
JPS6334856B2 (en
Inventor
Katsuaki Matsui
Masaru Yajima
Hiroyuki Naruse
Kozo Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP4129180A priority Critical patent/JPS56138140A/en
Publication of JPS56138140A publication Critical patent/JPS56138140A/en
Publication of JPS6334856B2 publication Critical patent/JPS6334856B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as an intermediate for an anti- inflammatory of a propionic acid compound, in high yield, safely and readily, by the reaction of 2-phenylpropionic acid or its ester with a dialkoxymethane in the presence of a condensing agent.
CONSTITUTION: A compound expressed by the formula I (R1 is H or alkyl) is reacted with a compound expressed by the formula II (R2 is alkyl) having no fear of carcinogenicity, in the presence of a condensing agent containing halogen, to give a compound expressed by formula III from readily available or synthesizable raw materials in high yield and readily with no danger in handling. A Friedel-Crafts catalyst containing halogen, a Lewis acid, protonic acid, preferably aluminum chloride, tin tetrachloride, and aluminum bromide may be used as the condensing agent.
COPYRIGHT: (C)1981,JPO&Japio
JP4129180A 1980-03-31 1980-03-31 Preparation of 2- p-halomethylphenyl propionic acid or its ester Granted JPS56138140A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4129180A JPS56138140A (en) 1980-03-31 1980-03-31 Preparation of 2- p-halomethylphenyl propionic acid or its ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4129180A JPS56138140A (en) 1980-03-31 1980-03-31 Preparation of 2- p-halomethylphenyl propionic acid or its ester

Publications (2)

Publication Number Publication Date
JPS56138140A true JPS56138140A (en) 1981-10-28
JPS6334856B2 JPS6334856B2 (en) 1988-07-12

Family

ID=12604337

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4129180A Granted JPS56138140A (en) 1980-03-31 1980-03-31 Preparation of 2- p-halomethylphenyl propionic acid or its ester

Country Status (1)

Country Link
JP (1) JPS56138140A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567293A (en) * 1981-10-14 1986-01-28 Kureha Kagaku Kogyo Kabushiki Kaisha 2-[Para-(2-substituted or unsubstituted-3,3,3-tri-fluoropropyl)phenyl]propionic acid or a salt thereof
EP0889020A1 (en) * 1997-07-04 1999-01-07 Kolon Industries, Inc. A process for the production of benzene derivatives
KR19990015050A (en) * 1997-08-01 1999-03-05 구광시 Method for preparing phenylpropionic acid derivative
KR100448641B1 (en) * 1997-08-01 2004-11-16 주식회사 코오롱 Method for producing phenyl propionic acid derivatives from 2-phenylpropionic acid by simple processing steps with high yield
KR100448642B1 (en) * 1997-08-01 2004-11-16 주식회사 코오롱 Method for producing phenyl propionic acid derivatives from 2-phenylpropionic acid by simple processing steps with high yield and purity
KR100448640B1 (en) * 1997-08-01 2004-11-16 주식회사 코오롱 Method for producing phenyl propionic acid derivatives with high yield and purity
CN106349051A (en) * 2016-08-25 2017-01-25 宁波博撷化学科技有限公司 Preparation method of methyl 2-(4-chloromethylphenyl)propionate

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63167550U (en) * 1987-04-22 1988-11-01

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567293A (en) * 1981-10-14 1986-01-28 Kureha Kagaku Kogyo Kabushiki Kaisha 2-[Para-(2-substituted or unsubstituted-3,3,3-tri-fluoropropyl)phenyl]propionic acid or a salt thereof
EP0889020A1 (en) * 1997-07-04 1999-01-07 Kolon Industries, Inc. A process for the production of benzene derivatives
KR19990015050A (en) * 1997-08-01 1999-03-05 구광시 Method for preparing phenylpropionic acid derivative
KR100448641B1 (en) * 1997-08-01 2004-11-16 주식회사 코오롱 Method for producing phenyl propionic acid derivatives from 2-phenylpropionic acid by simple processing steps with high yield
KR100448642B1 (en) * 1997-08-01 2004-11-16 주식회사 코오롱 Method for producing phenyl propionic acid derivatives from 2-phenylpropionic acid by simple processing steps with high yield and purity
KR100448640B1 (en) * 1997-08-01 2004-11-16 주식회사 코오롱 Method for producing phenyl propionic acid derivatives with high yield and purity
CN106349051A (en) * 2016-08-25 2017-01-25 宁波博撷化学科技有限公司 Preparation method of methyl 2-(4-chloromethylphenyl)propionate

Also Published As

Publication number Publication date
JPS6334856B2 (en) 1988-07-12

Similar Documents

Publication Publication Date Title
JPS56138140A (en) Preparation of 2- p-halomethylphenyl propionic acid or its ester
JPS5576829A (en) Beta,gamma-dihydropolyprenyl alcohol and hypotensive agent made from it
JPS5511538A (en) Production of methoxysilane
JPS5798235A (en) Preparation of metallic soap
JPS54128567A (en) 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative
JPS5798232A (en) 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal
JPS574987A (en) Pyridoindolecarboxylic acid derivative and its preparation
JPS5466640A (en) Novel acrylophenone derivative and its preparation
JPS5444627A (en) Production of acrylic acid derivative
JPS55108838A (en) Preparation of arkyl-1-chloro-2-oxocycloalkane carboxylate
JPS5770837A (en) Preparation of carboxylic acid derivative
JPS57126427A (en) Preparation of 1-substituted-azulene derivative
JPS5721371A (en) Quinolinoneiminecarboxylic ester derivative, its preparation and anti-inflammatory and analgesic agent composition containing the same
JPS5770883A (en) (2-thienylseleno)acetic acid and its preparation
JPS5645467A (en) Pantolactone derivative and its preparation
JPS5479266A (en) Producion of 2-thienylacetic acid or its ester
JPS5793933A (en) Preparation of 2-hydroxy-3-butenoic acid derivative
JPS5673086A (en) Preparation of cephalosporin compound
JPS56112954A (en) Stabilizer for halogen-containing resin
JPS5439042A (en) Preparation of 2-(4-iso butylphenyl)-propionic acid
JPS5212135A (en) Process for separation of 1,3,5-trialkylbenzene
JPS56122324A (en) Novel hydroquinone derivative and its preparation
JPS5655353A (en) Preparation of alkylenediamine derivative
JPS5686131A (en) Production of 2,2,2-trichloroethyl ester of acrylic acid or its derivative
JPS57118554A (en) Preparation of alpha-thio-alpha-aromatic-substituted propionic acid ester