JPS5793933A - Preparation of 2-hydroxy-3-butenoic acid derivative - Google Patents

Preparation of 2-hydroxy-3-butenoic acid derivative

Info

Publication number
JPS5793933A
JPS5793933A JP16969880A JP16969880A JPS5793933A JP S5793933 A JPS5793933 A JP S5793933A JP 16969880 A JP16969880 A JP 16969880A JP 16969880 A JP16969880 A JP 16969880A JP S5793933 A JPS5793933 A JP S5793933A
Authority
JP
Japan
Prior art keywords
hydroxy
preparation
acid derivative
butenoic acid
magnesium chloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16969880A
Other languages
Japanese (ja)
Other versions
JPH0645572B2 (en
Inventor
Shizuo Himoto
Katsura Kogure
Shinichi Kimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Priority to JP16969880A priority Critical patent/JPH0645572B2/en
Publication of JPS5793933A publication Critical patent/JPS5793933A/en
Publication of JPH0645572B2 publication Critical patent/JPH0645572B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled substance useful as an intermediate for an anti- inflammatory agent naproxen in high yield, by treting a glycidic ester derivative with magnesium chloride.
CONSTITUTION: One mole glycidic ester derivative of formulaI(R is lower alkyl) is reacted with 1.0W1.2mol magnesium chloride to give the titled substance of formula II. The reaction must be carried out in the absence of water; however, an anhydrous solvent, e.g. dioxane, acetic ester, toluene, tetrachloroethylene or DMF, may be used. Commercially available anhydrous magnetsium chloride can be directly used. The reaction conditions are as follows: 80W120°C and 2W4hr.
COPYRIGHT: (C)1982,JPO&Japio
JP16969880A 1980-12-03 1980-12-03 Process for producing 2-hydroxy-3-butenoic acid derivative Expired - Lifetime JPH0645572B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16969880A JPH0645572B2 (en) 1980-12-03 1980-12-03 Process for producing 2-hydroxy-3-butenoic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16969880A JPH0645572B2 (en) 1980-12-03 1980-12-03 Process for producing 2-hydroxy-3-butenoic acid derivative

Publications (2)

Publication Number Publication Date
JPS5793933A true JPS5793933A (en) 1982-06-11
JPH0645572B2 JPH0645572B2 (en) 1994-06-15

Family

ID=15891221

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16969880A Expired - Lifetime JPH0645572B2 (en) 1980-12-03 1980-12-03 Process for producing 2-hydroxy-3-butenoic acid derivative

Country Status (1)

Country Link
JP (1) JPH0645572B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764885A1 (en) * 1997-06-24 1998-12-24 Rhodia Chimie Sa USE OF MEDIUM FORCE ACID AS A ISOMERIZING CATALYST OF AN EPOXIDE HAVING A CARBONYL FUNCTION IN ALPHA OF EPOXIDE

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764885A1 (en) * 1997-06-24 1998-12-24 Rhodia Chimie Sa USE OF MEDIUM FORCE ACID AS A ISOMERIZING CATALYST OF AN EPOXIDE HAVING A CARBONYL FUNCTION IN ALPHA OF EPOXIDE
WO1998058898A1 (en) * 1997-06-24 1998-12-30 Rhodia Chimie Use of an acid of mean strength as izomerisation catalyst of an epoxide with a carbonyl function in the epoxide alpha

Also Published As

Publication number Publication date
JPH0645572B2 (en) 1994-06-15

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