JPS5793933A - Preparation of 2-hydroxy-3-butenoic acid derivative - Google Patents
Preparation of 2-hydroxy-3-butenoic acid derivativeInfo
- Publication number
- JPS5793933A JPS5793933A JP16969880A JP16969880A JPS5793933A JP S5793933 A JPS5793933 A JP S5793933A JP 16969880 A JP16969880 A JP 16969880A JP 16969880 A JP16969880 A JP 16969880A JP S5793933 A JPS5793933 A JP S5793933A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- preparation
- acid derivative
- butenoic acid
- magnesium chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain the titled substance useful as an intermediate for an anti- inflammatory agent naproxen in high yield, by treting a glycidic ester derivative with magnesium chloride.
CONSTITUTION: One mole glycidic ester derivative of formulaI(R is lower alkyl) is reacted with 1.0W1.2mol magnesium chloride to give the titled substance of formula II. The reaction must be carried out in the absence of water; however, an anhydrous solvent, e.g. dioxane, acetic ester, toluene, tetrachloroethylene or DMF, may be used. Commercially available anhydrous magnetsium chloride can be directly used. The reaction conditions are as follows: 80W120°C and 2W4hr.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16969880A JPH0645572B2 (en) | 1980-12-03 | 1980-12-03 | Process for producing 2-hydroxy-3-butenoic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16969880A JPH0645572B2 (en) | 1980-12-03 | 1980-12-03 | Process for producing 2-hydroxy-3-butenoic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5793933A true JPS5793933A (en) | 1982-06-11 |
JPH0645572B2 JPH0645572B2 (en) | 1994-06-15 |
Family
ID=15891221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16969880A Expired - Lifetime JPH0645572B2 (en) | 1980-12-03 | 1980-12-03 | Process for producing 2-hydroxy-3-butenoic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0645572B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2764885A1 (en) * | 1997-06-24 | 1998-12-24 | Rhodia Chimie Sa | USE OF MEDIUM FORCE ACID AS A ISOMERIZING CATALYST OF AN EPOXIDE HAVING A CARBONYL FUNCTION IN ALPHA OF EPOXIDE |
-
1980
- 1980-12-03 JP JP16969880A patent/JPH0645572B2/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2764885A1 (en) * | 1997-06-24 | 1998-12-24 | Rhodia Chimie Sa | USE OF MEDIUM FORCE ACID AS A ISOMERIZING CATALYST OF AN EPOXIDE HAVING A CARBONYL FUNCTION IN ALPHA OF EPOXIDE |
WO1998058898A1 (en) * | 1997-06-24 | 1998-12-30 | Rhodia Chimie | Use of an acid of mean strength as izomerisation catalyst of an epoxide with a carbonyl function in the epoxide alpha |
Also Published As
Publication number | Publication date |
---|---|
JPH0645572B2 (en) | 1994-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS55164686A (en) | Novel maytansinoid compound and its preparation | |
JPS54119494A (en) | Preparation of cephalosporin compound | |
JPS5793933A (en) | Preparation of 2-hydroxy-3-butenoic acid derivative | |
ES8307236A1 (en) | Process for the preparation of a furan derivative. | |
ES8703401A1 (en) | Process for the preparation of esters of 4-acyloxy-3-keto-butyric acid. | |
JPS55151549A (en) | Production of guanidinocaproic ester | |
JPS56118081A (en) | Preparation of 6-methoxy-1,8-naphthyridine | |
JPS57167964A (en) | Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative | |
JPS5735556A (en) | Preparation of guanidinomethylcyclohexanecarboxylic acid ester | |
JPS54138551A (en) | Novel asymmetric synthesis of optically active 2-alkanoyl- 1,2,3,4-tetrahydro-2-naphthol compound | |
JPS577463A (en) | Preparation of sulfuric half ester compound | |
JPS55130936A (en) | Novel preparation of alpha-alkylhomophthalic acid or its diester | |
JPS5731685A (en) | Preparation of 2',3',5'-triacetoxy-5-fluorouridine | |
JPS5436257A (en) | Substituted benzoic acid amide | |
JPS5758689A (en) | Novel preparation of 7-substituted or unsubstituted amino-3-substituted methylcephem carboxylic acids | |
JPS5663973A (en) | Novel thiadiazol-5-ylthiol ester and its preparation | |
JPS5767582A (en) | Preparation of cephalosporin derivative | |
JPS56140961A (en) | Preparation of sulfonate of p-ethoxycarbonylphenyl epsilon-guanidinocaproate | |
JPS56140962A (en) | Preparation of p-ethoxycarbonylphenyl epsilon-guanidinocaproate | |
JPS54151971A (en) | Preparation of imidazole derivative | |
JPS5522613A (en) | Preparation of 2-hydroxy-3-butenoic acid derivative | |
JPS55102584A (en) | Preparation of alpha-sulfobenzylpenicilin and its salt | |
JPS5692290A (en) | Preparation of 7-amino-3-substituted methylcephem carboxylic acid, its salt or ester | |
JPS5373566A (en) | 7,8,9,10,-tetrahydrophenanthridone-3-acetic acids | |
JPS57116057A (en) | Preparation of 2-benzothiazolinone derivative or salt thereof |