JPS55102584A - Preparation of alpha-sulfobenzylpenicilin and its salt - Google Patents
Preparation of alpha-sulfobenzylpenicilin and its saltInfo
- Publication number
- JPS55102584A JPS55102584A JP932079A JP932079A JPS55102584A JP S55102584 A JPS55102584 A JP S55102584A JP 932079 A JP932079 A JP 932079A JP 932079 A JP932079 A JP 932079A JP S55102584 A JPS55102584 A JP S55102584A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- reaction
- acid
- hydrolyzing
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
PURPOSE: To prepare the title compound useful as an antibacterial agent, in high purity and yield, with simple procedure, by reacting a specific penicillin derived from natural penicillin with a reactive derivative of α-sulfophenylacetic acid, and hydrolyzing the reaction product.
CONSTITUTION: The objective compound of formula II is prepared by (1) reacting an iminoether of formula I (R1 is lower alkyl; R4 is a group constituting an ester or a mixed acid anhydride) with a reactive derivative of α-sulfophenylacetic acid in an anhydrous solvent at -10W-40°C, pref. in the presence of a base, and (2) hydrolyzing the reaction product to eliminate the protecting groups. The starting compound I can be easily prepared from a natural penicillin such as the one represented by the formula VI by the reaction of the formula. Since 6-aminopenicillanic acid which is stable and difficult to be separated and purified, is not formed as an intermediate in the present process, the reaction can be carried out easily.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP932079A JPS55102584A (en) | 1979-01-30 | 1979-01-30 | Preparation of alpha-sulfobenzylpenicilin and its salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP932079A JPS55102584A (en) | 1979-01-30 | 1979-01-30 | Preparation of alpha-sulfobenzylpenicilin and its salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS55102584A true JPS55102584A (en) | 1980-08-05 |
Family
ID=11717164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP932079A Pending JPS55102584A (en) | 1979-01-30 | 1979-01-30 | Preparation of alpha-sulfobenzylpenicilin and its salt |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55102584A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101974018A (en) * | 2010-09-08 | 2011-02-16 | 海南美兰史克制药有限公司 | Sulbenicillin sodium compound and novel method thereof |
-
1979
- 1979-01-30 JP JP932079A patent/JPS55102584A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101974018A (en) * | 2010-09-08 | 2011-02-16 | 海南美兰史克制药有限公司 | Sulbenicillin sodium compound and novel method thereof |
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