JPS54145628A - Preparation of p-hydroxyphenylglycine - Google Patents
Preparation of p-hydroxyphenylglycineInfo
- Publication number
- JPS54145628A JPS54145628A JP5380578A JP5380578A JPS54145628A JP S54145628 A JPS54145628 A JP S54145628A JP 5380578 A JP5380578 A JP 5380578A JP 5380578 A JP5380578 A JP 5380578A JP S54145628 A JPS54145628 A JP S54145628A
- Authority
- JP
- Japan
- Prior art keywords
- pref
- mole
- moles
- hydroxyphenylglycine
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the title compound useful as an intermediate of penicillanic acid or its derivative, in high yield, by reacting phenol, glyoxylic acid, and ammonium carbamate in one batch, at low temperature.
CONSTITUTION: p-Hydroxyphenylglycine is prepared by reacting glyoxylic acid or its precursor (1 mole) with phenol (≥1 mole, pref. 1W5 moles) and ammonium carbamate (≥1 mole, pref. 1W5 moles) in the presence oof water or a mixture of water and an organic solvent, at 0W60°C, pref. at 10W25°C. The compound thus obtained can be easily purified to crystals of a purity of 90W99% by conventional purification process.
EFFECT: The objective compound can be prepared without complicated operations and without using excessive ammonium salt.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5380578A JPS54145628A (en) | 1978-05-08 | 1978-05-08 | Preparation of p-hydroxyphenylglycine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5380578A JPS54145628A (en) | 1978-05-08 | 1978-05-08 | Preparation of p-hydroxyphenylglycine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54145628A true JPS54145628A (en) | 1979-11-14 |
JPS5751826B2 JPS5751826B2 (en) | 1982-11-04 |
Family
ID=12953009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5380578A Granted JPS54145628A (en) | 1978-05-08 | 1978-05-08 | Preparation of p-hydroxyphenylglycine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54145628A (en) |
-
1978
- 1978-05-08 JP JP5380578A patent/JPS54145628A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS5751826B2 (en) | 1982-11-04 |
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