JPS54145628A - Preparation of p-hydroxyphenylglycine - Google Patents

Preparation of p-hydroxyphenylglycine

Info

Publication number
JPS54145628A
JPS54145628A JP5380578A JP5380578A JPS54145628A JP S54145628 A JPS54145628 A JP S54145628A JP 5380578 A JP5380578 A JP 5380578A JP 5380578 A JP5380578 A JP 5380578A JP S54145628 A JPS54145628 A JP S54145628A
Authority
JP
Japan
Prior art keywords
pref
mole
moles
hydroxyphenylglycine
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5380578A
Other languages
Japanese (ja)
Other versions
JPS5751826B2 (en
Inventor
Iwao Kobayashi
Masayuki Yasui
Masayuki Kobayashi
Hideaki Iriuchijima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denka Co Ltd
Original Assignee
Denki Kagaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denki Kagaku Kogyo KK filed Critical Denki Kagaku Kogyo KK
Priority to JP5380578A priority Critical patent/JPS54145628A/en
Publication of JPS54145628A publication Critical patent/JPS54145628A/en
Publication of JPS5751826B2 publication Critical patent/JPS5751826B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound useful as an intermediate of penicillanic acid or its derivative, in high yield, by reacting phenol, glyoxylic acid, and ammonium carbamate in one batch, at low temperature.
CONSTITUTION: p-Hydroxyphenylglycine is prepared by reacting glyoxylic acid or its precursor (1 mole) with phenol (≥1 mole, pref. 1W5 moles) and ammonium carbamate (≥1 mole, pref. 1W5 moles) in the presence oof water or a mixture of water and an organic solvent, at 0W60°C, pref. at 10W25°C. The compound thus obtained can be easily purified to crystals of a purity of 90W99% by conventional purification process.
EFFECT: The objective compound can be prepared without complicated operations and without using excessive ammonium salt.
COPYRIGHT: (C)1979,JPO&Japio
JP5380578A 1978-05-08 1978-05-08 Preparation of p-hydroxyphenylglycine Granted JPS54145628A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5380578A JPS54145628A (en) 1978-05-08 1978-05-08 Preparation of p-hydroxyphenylglycine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5380578A JPS54145628A (en) 1978-05-08 1978-05-08 Preparation of p-hydroxyphenylglycine

Publications (2)

Publication Number Publication Date
JPS54145628A true JPS54145628A (en) 1979-11-14
JPS5751826B2 JPS5751826B2 (en) 1982-11-04

Family

ID=12953009

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5380578A Granted JPS54145628A (en) 1978-05-08 1978-05-08 Preparation of p-hydroxyphenylglycine

Country Status (1)

Country Link
JP (1) JPS54145628A (en)

Also Published As

Publication number Publication date
JPS5751826B2 (en) 1982-11-04

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