JPS579774A - Production of 2-aminobenzothiazole - Google Patents

Production of 2-aminobenzothiazole

Info

Publication number
JPS579774A
JPS579774A JP8405980A JP8405980A JPS579774A JP S579774 A JPS579774 A JP S579774A JP 8405980 A JP8405980 A JP 8405980A JP 8405980 A JP8405980 A JP 8405980A JP S579774 A JPS579774 A JP S579774A
Authority
JP
Japan
Prior art keywords
phenylthiourea
sulfuric acid
compound
solvent
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8405980A
Other languages
Japanese (ja)
Other versions
JPH0140833B2 (en
Inventor
Shigeo Yamamura
Takeshi Kojima
Mitsuru Kurosawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP8405980A priority Critical patent/JPS579774A/en
Publication of JPS579774A publication Critical patent/JPS579774A/en
Publication of JPH0140833B2 publication Critical patent/JPH0140833B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PURPOSE: The thermal ring closure of a phenylthiourea is effected using very inexpensive sulfuric acid as a solvent to produce the titled compound of high purity used as a synthetic intermediate of medicines in a short time in high yield.
CONSTITUTION: Sulfuric acid is used as a solvent to effect the thermal ring closure of a phenylthiourea of formula I (A on the benzene ring is 1W4C alkyl, halogen, nitro) in the presence of a catalyst of bromine or iodine at 20W120°C, thus producing the compound of formula II. The concentration of the sulfuric acid is about 85W100%, preferably 90W100% and the amount is 3W10 times the weight of the phenylthiourea usually. The example of the compound of foumula I is phenylthiourea or 2-methylphenylthiourea.
COPYRIGHT: (C)1982,JPO&Japio
JP8405980A 1980-06-23 1980-06-23 Production of 2-aminobenzothiazole Granted JPS579774A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8405980A JPS579774A (en) 1980-06-23 1980-06-23 Production of 2-aminobenzothiazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8405980A JPS579774A (en) 1980-06-23 1980-06-23 Production of 2-aminobenzothiazole

Publications (2)

Publication Number Publication Date
JPS579774A true JPS579774A (en) 1982-01-19
JPH0140833B2 JPH0140833B2 (en) 1989-08-31

Family

ID=13819915

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8405980A Granted JPS579774A (en) 1980-06-23 1980-06-23 Production of 2-aminobenzothiazole

Country Status (1)

Country Link
JP (1) JPS579774A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60123480A (en) * 1983-12-05 1985-07-02 Sumitomo Chem Co Ltd Preparation of 2-imino-benzthiazolines
JPS61268688A (en) * 1985-05-21 1986-11-28 Nippon Kayaku Co Ltd Production of 2,6-diaminobenzo-(1,2-d:4,5-d')-bisthiazole
EP0529600A1 (en) * 1991-08-30 1993-03-03 Hoechst Aktiengesellschaft Process for the preparation of 2-aminobenzothiazoles
US20140275553A1 (en) * 2007-11-21 2014-09-18 Decode Genetics Ehf Substituted benzoazole pde4 inhibitors for treating pulmonary and cardiovascular disorders

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60123480A (en) * 1983-12-05 1985-07-02 Sumitomo Chem Co Ltd Preparation of 2-imino-benzthiazolines
JPS61268688A (en) * 1985-05-21 1986-11-28 Nippon Kayaku Co Ltd Production of 2,6-diaminobenzo-(1,2-d:4,5-d')-bisthiazole
JPH0523272B2 (en) * 1985-05-21 1993-04-02 Nippon Kayaku Kk
EP0529600A1 (en) * 1991-08-30 1993-03-03 Hoechst Aktiengesellschaft Process for the preparation of 2-aminobenzothiazoles
US5374737A (en) * 1991-08-30 1994-12-20 Hoechst Aktiengesellschaft Process for the preparation of 2-aminobenzothiazoles
US20140275553A1 (en) * 2007-11-21 2014-09-18 Decode Genetics Ehf Substituted benzoazole pde4 inhibitors for treating pulmonary and cardiovascular disorders

Also Published As

Publication number Publication date
JPH0140833B2 (en) 1989-08-31

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