JPS55104286A - Preparation of thienoimidazoline compound - Google Patents

Preparation of thienoimidazoline compound

Info

Publication number
JPS55104286A
JPS55104286A JP1175879A JP1175879A JPS55104286A JP S55104286 A JPS55104286 A JP S55104286A JP 1175879 A JP1175879 A JP 1175879A JP 1175879 A JP1175879 A JP 1175879A JP S55104286 A JPS55104286 A JP S55104286A
Authority
JP
Japan
Prior art keywords
acid
benzyl
compound
thienoimidazoline
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1175879A
Other languages
Japanese (ja)
Other versions
JPS638954B2 (en
Inventor
Takeo Takahashi
Kozo Shimako
Kaoru Maejima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP1175879A priority Critical patent/JPS55104286A/en
Publication of JPS55104286A publication Critical patent/JPS55104286A/en
Publication of JPS638954B2 publication Critical patent/JPS638954B2/ja
Granted legal-status Critical Current

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PURPOSE: To prepare the title compound known as vitamin H, and useful as a growth-promoting agent and remdey for skin disease, in high yield and purity, at a low cost, by heating a benzyl biotin derivative in the presence of an alkanesulfonic acid such as methanesulfonic acid.
CONSTITUTION: Cis-tetrahydro-2-oxothieno[3,4-d]-imidazoline-4-valeric acid (biotin) is prepared by reacting 100 pts. wt. of a compound of formula (R1,2 are H or benzyl, provided that at least one of R1,2 is benzyl; R3 is H or carboxyl) with pref. 300W5000 parts of an alkanesulfonic acid (e.g. methanesulfonic acid and ethanesulfonic acid) at 110W150°C for 0.5W10hr. Crude crystals of the objective compound obtained by cooling the reaction mixture, is recrystallized with water.
COPYRIGHT: (C)1980,JPO&Japio
JP1175879A 1979-02-02 1979-02-02 Preparation of thienoimidazoline compound Granted JPS55104286A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1175879A JPS55104286A (en) 1979-02-02 1979-02-02 Preparation of thienoimidazoline compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1175879A JPS55104286A (en) 1979-02-02 1979-02-02 Preparation of thienoimidazoline compound

Publications (2)

Publication Number Publication Date
JPS55104286A true JPS55104286A (en) 1980-08-09
JPS638954B2 JPS638954B2 (en) 1988-02-25

Family

ID=11786875

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1175879A Granted JPS55104286A (en) 1979-02-02 1979-02-02 Preparation of thienoimidazoline compound

Country Status (1)

Country Link
JP (1) JPS55104286A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02136996U (en) * 1989-04-18 1990-11-15
JPH037824A (en) * 1989-06-02 1991-01-16 Sanyo Electric Co Ltd Heat exchanging unit
JPH09227564A (en) 1995-12-20 1997-09-02 Sumitomo Chem Co Ltd Production of imidazole derivative
CA2193774C (en) 1995-12-26 2005-02-01 Norihiko Hirata Process for producing 1-hydroxythienoimidazole carboxylic acid and thienoimidazole carboxylic acid
CH693745A5 (en) 1998-12-24 2004-01-15 Sumitomo Chemical Co Process for the preparation of hexahydro-2-oxo-1H-thieno (3,4-d) imidazol-4-pentansaeure.

Also Published As

Publication number Publication date
JPS638954B2 (en) 1988-02-25

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