JPS54145629A - Preparation of p-hydroxyphenylglycine - Google Patents
Preparation of p-hydroxyphenylglycineInfo
- Publication number
- JPS54145629A JPS54145629A JP5380678A JP5380678A JPS54145629A JP S54145629 A JPS54145629 A JP S54145629A JP 5380678 A JP5380678 A JP 5380678A JP 5380678 A JP5380678 A JP 5380678A JP S54145629 A JPS54145629 A JP S54145629A
- Authority
- JP
- Japan
- Prior art keywords
- mole
- pref
- moles
- prepared
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound useful as an intermediate of penicillanic acid or its derivative, in high yield, by reacting phenol, glyoxylic acid, and ammonium carbonate in one batch, at low temperature.
CONSTITUTION: The objective compound is prepared by reacting glyoxylic acid or its precursor (1 mole) with phenol (≥1 mole, pref. 1W5 moles) and ammonium carbonate (≥1 mole, pref. 1W5 moles) in the presence of water or a mixture of water and an organic solvent, at 0W60°C. The compound can be separated from the reaction mixture at a purity of 90W99% by known process, and crystallized by conventional purification method. When the crystallization of the product takes place in the reaction system, the filtrate after the removal of the crystals can be used as the reaction solvent, which contributes to the effective utilization of the raw materials and the prevention of pollution of waste liquid.
EFFECT: The objective compound can be prepared without complicated operations and without using excessive ammonium salt.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5380678A JPS54145629A (en) | 1978-05-08 | 1978-05-08 | Preparation of p-hydroxyphenylglycine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5380678A JPS54145629A (en) | 1978-05-08 | 1978-05-08 | Preparation of p-hydroxyphenylglycine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54145629A true JPS54145629A (en) | 1979-11-14 |
Family
ID=12953033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5380678A Pending JPS54145629A (en) | 1978-05-08 | 1978-05-08 | Preparation of p-hydroxyphenylglycine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54145629A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53135951A (en) * | 1977-05-02 | 1978-11-28 | Tanabe Seiyaku Co Ltd | Preparation of hydroxyphenyl glycine derivative |
-
1978
- 1978-05-08 JP JP5380678A patent/JPS54145629A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53135951A (en) * | 1977-05-02 | 1978-11-28 | Tanabe Seiyaku Co Ltd | Preparation of hydroxyphenyl glycine derivative |
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