JPS54112881A - Preparation of 2-mercaptopyrimidine hydrochloride - Google Patents

Preparation of 2-mercaptopyrimidine hydrochloride

Info

Publication number
JPS54112881A
JPS54112881A JP1919778A JP1919778A JPS54112881A JP S54112881 A JPS54112881 A JP S54112881A JP 1919778 A JP1919778 A JP 1919778A JP 1919778 A JP1919778 A JP 1919778A JP S54112881 A JPS54112881 A JP S54112881A
Authority
JP
Japan
Prior art keywords
hcl gas
mercaptopyrimidine
hydrochloride
pref
thiourea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1919778A
Other languages
Japanese (ja)
Other versions
JPS6058913B2 (en
Inventor
Tamiyoshi Mori
Mitsuhiko Tamura
Eisuke Hirayama
Hisaharu Hotta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP1919778A priority Critical patent/JPS6058913B2/en
Publication of JPS54112881A publication Critical patent/JPS54112881A/en
Publication of JPS6058913B2 publication Critical patent/JPS6058913B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound, useful as an amino acid protector, continuously, in high yield, by reacting a β-dicarbonyl compound and thiourea with HCl gas in water, crystallizing the reaction product, and recycling the filtrate as the solvent of the reaction system.
CONSTITUTION: 2-Mercaptopyrimidine hydrochloride of formula II (R1,2 are H, 1-4C lower alkyl) is prepared by (1) introducing HCl gas into an aqueous solvent containing 0.8W1.5 moles of a β-dicarbonyl compound of formula I and 1 mole of thiourea at ≥65°C, pref. 70W95°C for ≥15 min., (2) crystallizing the reaction product by cooling the solution, and (3) filtering the crystals. The reaction is pref. performed continuously, by introducing and absorbing the HCl gas into the filtrate.
COPYRIGHT: (C)1979,JPO&Japio
JP1919778A 1978-02-22 1978-02-22 Method for producing 2-mercaptopyrimidine hydrochloride Expired JPS6058913B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1919778A JPS6058913B2 (en) 1978-02-22 1978-02-22 Method for producing 2-mercaptopyrimidine hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1919778A JPS6058913B2 (en) 1978-02-22 1978-02-22 Method for producing 2-mercaptopyrimidine hydrochloride

Publications (2)

Publication Number Publication Date
JPS54112881A true JPS54112881A (en) 1979-09-04
JPS6058913B2 JPS6058913B2 (en) 1985-12-23

Family

ID=11992617

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1919778A Expired JPS6058913B2 (en) 1978-02-22 1978-02-22 Method for producing 2-mercaptopyrimidine hydrochloride

Country Status (1)

Country Link
JP (1) JPS6058913B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55157572A (en) * 1979-05-25 1980-12-08 Nitto Boseki Co Ltd Preparation of 2-mercapto-4,6-dimethylpyrimidine hydrochloride

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55157572A (en) * 1979-05-25 1980-12-08 Nitto Boseki Co Ltd Preparation of 2-mercapto-4,6-dimethylpyrimidine hydrochloride
JPS6144870B2 (en) * 1979-05-25 1986-10-04 Nitto Boseki Co Ltd

Also Published As

Publication number Publication date
JPS6058913B2 (en) 1985-12-23

Similar Documents

Publication Publication Date Title
JPS54112881A (en) Preparation of 2-mercaptopyrimidine hydrochloride
JPS6440467A (en) Novel substituted diphenylimidazole derivative
JPS57108072A (en) Preparation of n-acylcarnosine
JPS57146786A (en) Optically active borane compound and preparation of optically active compound using the same
JPS57131777A (en) Preparation of piperazine derivative
JPS55130939A (en) Preparation of carbonic acid ester
JPS5731682A (en) Preparation of alkylene carbonate
JPS5212146A (en) Process for preparation of p- acetylaminobenzene-sufonylchloride
JPS5540611A (en) Preparation of alkyl orthoacetate
JPS5555160A (en) Preparation of substituted benzamide
JPS55122788A (en) Preparation of cephalosporin compound
JPS5479283A (en) Preparation of fluoroalkyl pyridine
JPS5758645A (en) Preparation of carbonate
JPS55151547A (en) Production of guanidinocapronic ester
JPS55104227A (en) Preparation of 3-pentenoic acid
JPS5551079A (en) Preparation of benzoxazole derivative
JPS572264A (en) Preparation of n-substituted thiolcarbamate
JPS5576863A (en) Preparation of 2-chloronicotinic acid
JPS5735568A (en) Preparation of cyclohexanol-2,2,6,6,-tetrakis hydroxymethyl tetranicotinate
JPS55111468A (en) Preparation of n-benzyl-tetrahydro isoquinoline derivative
JPS5663973A (en) Novel thiadiazol-5-ylthiol ester and its preparation
SG43092A1 (en) Process for preparing 5-arylhydantoin
JPS57193484A (en) Preparation of rifampicin
JPS54145628A (en) Preparation of p-hydroxyphenylglycine
JPS55157572A (en) Preparation of 2-mercapto-4,6-dimethylpyrimidine hydrochloride