JPS5555160A - Preparation of substituted benzamide - Google Patents

Preparation of substituted benzamide

Info

Publication number
JPS5555160A
JPS5555160A JP12657279A JP12657279A JPS5555160A JP S5555160 A JPS5555160 A JP S5555160A JP 12657279 A JP12657279 A JP 12657279A JP 12657279 A JP12657279 A JP 12657279A JP S5555160 A JPS5555160 A JP S5555160A
Authority
JP
Japan
Prior art keywords
formula
lower alkyl
alkyl group
addition salt
primary amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12657279A
Other languages
Japanese (ja)
Other versions
JPS6016931B2 (en
Inventor
Rikio Ouchi
Hiroshi Oyabu
Shigeru Kurata
Yasushi Suzuki
Takeo Shibata
Kunio Tsukamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Priority to JP12657279A priority Critical patent/JPS6016931B2/en
Publication of JPS5555160A publication Critical patent/JPS5555160A/en
Publication of JPS6016931B2 publication Critical patent/JPS6016931B2/en
Expired legal-status Critical Current

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  • Pyrrole Compounds (AREA)

Abstract

PURPOSE: To obtain the title high-purity compound, e.g. an antiemetic psychotherapeutic drug, or antitumor agent simply in high yield, by reacting an easily synthesized inexpensive novel oxazoline derivative or its acid addition salt with a primary amine.
CONSTITUTION: A novel inexpensive easily synthesized oxazoline derivative of formula I: (A is lower alkyl group; X is reactive acid residue; Z is H or sulfamoyl group), e.g. 2-(2'-methoxy-5'-sulfamoylphenyl)-5-(3'-bromopropyl-4,5-dihydrooxazole, or its acid addition salt is reacted with a primary amine of the formula H2N-R (R is lower alkyl group) at 60°C or above to give a substituted benzamide of formula II, e.g. Sulpiride of formula III, a hypothalamic antitumor agent. The high- purity compound can be obtained in high yield without requiring complicated steps.
COPYRIGHT: (C)1980,JPO&Japio
JP12657279A 1979-10-01 1979-10-01 Method for producing substituted benzoic acid amide Expired JPS6016931B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12657279A JPS6016931B2 (en) 1979-10-01 1979-10-01 Method for producing substituted benzoic acid amide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12657279A JPS6016931B2 (en) 1979-10-01 1979-10-01 Method for producing substituted benzoic acid amide

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2224976A Division JPS52106863A (en) 1976-03-03 1976-03-03 Synthesis of substituted benzamides

Publications (2)

Publication Number Publication Date
JPS5555160A true JPS5555160A (en) 1980-04-22
JPS6016931B2 JPS6016931B2 (en) 1985-04-30

Family

ID=14938477

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12657279A Expired JPS6016931B2 (en) 1979-10-01 1979-10-01 Method for producing substituted benzoic acid amide

Country Status (1)

Country Link
JP (1) JPS6016931B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1568696A1 (en) * 2004-02-26 2005-08-31 4Sc Ag Compounds as inhibitors of cell proliferation and viral infections

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6275193A (en) * 1985-09-27 1987-04-07 日東工器株式会社 Joint with proceeding path and returning path
GB8722562D0 (en) * 1987-09-25 1987-11-04 Goodfellow Associates Ltd Connector for fluid carrying conduits

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1568696A1 (en) * 2004-02-26 2005-08-31 4Sc Ag Compounds as inhibitors of cell proliferation and viral infections

Also Published As

Publication number Publication date
JPS6016931B2 (en) 1985-04-30

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