JPS5555160A - Preparation of substituted benzamide - Google Patents
Preparation of substituted benzamideInfo
- Publication number
- JPS5555160A JPS5555160A JP12657279A JP12657279A JPS5555160A JP S5555160 A JPS5555160 A JP S5555160A JP 12657279 A JP12657279 A JP 12657279A JP 12657279 A JP12657279 A JP 12657279A JP S5555160 A JPS5555160 A JP S5555160A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- lower alkyl
- alkyl group
- addition salt
- primary amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyrrole Compounds (AREA)
Abstract
PURPOSE: To obtain the title high-purity compound, e.g. an antiemetic psychotherapeutic drug, or antitumor agent simply in high yield, by reacting an easily synthesized inexpensive novel oxazoline derivative or its acid addition salt with a primary amine.
CONSTITUTION: A novel inexpensive easily synthesized oxazoline derivative of formula I: (A is lower alkyl group; X is reactive acid residue; Z is H or sulfamoyl group), e.g. 2-(2'-methoxy-5'-sulfamoylphenyl)-5-(3'-bromopropyl-4,5-dihydrooxazole, or its acid addition salt is reacted with a primary amine of the formula H2N-R (R is lower alkyl group) at 60°C or above to give a substituted benzamide of formula II, e.g. Sulpiride of formula III, a hypothalamic antitumor agent. The high- purity compound can be obtained in high yield without requiring complicated steps.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12657279A JPS6016931B2 (en) | 1979-10-01 | 1979-10-01 | Method for producing substituted benzoic acid amide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12657279A JPS6016931B2 (en) | 1979-10-01 | 1979-10-01 | Method for producing substituted benzoic acid amide |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2224976A Division JPS52106863A (en) | 1976-03-03 | 1976-03-03 | Synthesis of substituted benzamides |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5555160A true JPS5555160A (en) | 1980-04-22 |
JPS6016931B2 JPS6016931B2 (en) | 1985-04-30 |
Family
ID=14938477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12657279A Expired JPS6016931B2 (en) | 1979-10-01 | 1979-10-01 | Method for producing substituted benzoic acid amide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6016931B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1568696A1 (en) * | 2004-02-26 | 2005-08-31 | 4Sc Ag | Compounds as inhibitors of cell proliferation and viral infections |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6275193A (en) * | 1985-09-27 | 1987-04-07 | 日東工器株式会社 | Joint with proceeding path and returning path |
GB8722562D0 (en) * | 1987-09-25 | 1987-11-04 | Goodfellow Associates Ltd | Connector for fluid carrying conduits |
-
1979
- 1979-10-01 JP JP12657279A patent/JPS6016931B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1568696A1 (en) * | 2004-02-26 | 2005-08-31 | 4Sc Ag | Compounds as inhibitors of cell proliferation and viral infections |
Also Published As
Publication number | Publication date |
---|---|
JPS6016931B2 (en) | 1985-04-30 |
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