JPS55127366A - Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole - Google Patents
Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indoleInfo
- Publication number
- JPS55127366A JPS55127366A JP3325079A JP3325079A JPS55127366A JP S55127366 A JPS55127366 A JP S55127366A JP 3325079 A JP3325079 A JP 3325079A JP 3325079 A JP3325079 A JP 3325079A JP S55127366 A JPS55127366 A JP S55127366A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- salt
- compound
- trialkylsilylisopropylamine
- hydroxyindole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Indole Compounds (AREA)
Abstract
PURPOSE: To prepare the title compound, easily, by alkylating a 4-hydroxyindole salt using a novel additon compound of a trialkylsilylisopropylamine and an epihalohydrin as an alkylating agent, and then hydrolyzing the product.
CONSTITUTION: A novel trialkylsiloxyhaloalkylamine of formula I (X is Cl or Br) is prepared exclusively and easily, by reacting a trialkylsilylisopropylamine of formula R3Si-NH-CH(CH3)2 (R is methyl or ethyl) with an epihalohydrin by heating. An alkali metal salt of 4-hydroxyindole of formula II is alkylated with the compound I obtained above, and the trialkylsiloxy group of the product is hydrolyzed to obtain the title compound of formula III, which may be further converted to a salt by reacting with corresponding inorganic or organic acid.
USE: Remedy for arrythmetic auricular fabrillation and coronary diseases.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3325079A JPS55127366A (en) | 1979-03-23 | 1979-03-23 | Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3325079A JPS55127366A (en) | 1979-03-23 | 1979-03-23 | Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55127366A true JPS55127366A (en) | 1980-10-02 |
Family
ID=12381239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3325079A Pending JPS55127366A (en) | 1979-03-23 | 1979-03-23 | Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55127366A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0467637A1 (en) * | 1990-07-18 | 1992-01-22 | Senju Pharmaceutical Co., Ltd. | Pyrazolo(1,5-a)pyridine compounds, and production and use thereof |
-
1979
- 1979-03-23 JP JP3325079A patent/JPS55127366A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0467637A1 (en) * | 1990-07-18 | 1992-01-22 | Senju Pharmaceutical Co., Ltd. | Pyrazolo(1,5-a)pyridine compounds, and production and use thereof |
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