JPS55127366A - Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole - Google Patents

Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole

Info

Publication number
JPS55127366A
JPS55127366A JP3325079A JP3325079A JPS55127366A JP S55127366 A JPS55127366 A JP S55127366A JP 3325079 A JP3325079 A JP 3325079A JP 3325079 A JP3325079 A JP 3325079A JP S55127366 A JPS55127366 A JP S55127366A
Authority
JP
Japan
Prior art keywords
formula
salt
compound
trialkylsilylisopropylamine
hydroxyindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3325079A
Other languages
Japanese (ja)
Inventor
Keiichiro Uchida
Toshio Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Shiono Koryo Kaisha Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Shiono Koryo Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd, Shiono Koryo Kaisha Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP3325079A priority Critical patent/JPS55127366A/en
Publication of JPS55127366A publication Critical patent/JPS55127366A/en
Pending legal-status Critical Current

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  • Indole Compounds (AREA)

Abstract

PURPOSE: To prepare the title compound, easily, by alkylating a 4-hydroxyindole salt using a novel additon compound of a trialkylsilylisopropylamine and an epihalohydrin as an alkylating agent, and then hydrolyzing the product.
CONSTITUTION: A novel trialkylsiloxyhaloalkylamine of formula I (X is Cl or Br) is prepared exclusively and easily, by reacting a trialkylsilylisopropylamine of formula R3Si-NH-CH(CH3)2 (R is methyl or ethyl) with an epihalohydrin by heating. An alkali metal salt of 4-hydroxyindole of formula II is alkylated with the compound I obtained above, and the trialkylsiloxy group of the product is hydrolyzed to obtain the title compound of formula III, which may be further converted to a salt by reacting with corresponding inorganic or organic acid.
USE: Remedy for arrythmetic auricular fabrillation and coronary diseases.
COPYRIGHT: (C)1980,JPO&Japio
JP3325079A 1979-03-23 1979-03-23 Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole Pending JPS55127366A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3325079A JPS55127366A (en) 1979-03-23 1979-03-23 Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3325079A JPS55127366A (en) 1979-03-23 1979-03-23 Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole

Publications (1)

Publication Number Publication Date
JPS55127366A true JPS55127366A (en) 1980-10-02

Family

ID=12381239

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3325079A Pending JPS55127366A (en) 1979-03-23 1979-03-23 Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole

Country Status (1)

Country Link
JP (1) JPS55127366A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0467637A1 (en) * 1990-07-18 1992-01-22 Senju Pharmaceutical Co., Ltd. Pyrazolo(1,5-a)pyridine compounds, and production and use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0467637A1 (en) * 1990-07-18 1992-01-22 Senju Pharmaceutical Co., Ltd. Pyrazolo(1,5-a)pyridine compounds, and production and use thereof

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