JPS572268A - Preparation of 5- p-chlorobenzoyl -1,4-dimethylpyrrole- 2-acetic acid - Google Patents

Preparation of 5- p-chlorobenzoyl -1,4-dimethylpyrrole- 2-acetic acid

Info

Publication number
JPS572268A
JPS572268A JP7682580A JP7682580A JPS572268A JP S572268 A JPS572268 A JP S572268A JP 7682580 A JP7682580 A JP 7682580A JP 7682580 A JP7682580 A JP 7682580A JP S572268 A JPS572268 A JP S572268A
Authority
JP
Japan
Prior art keywords
formula
chlorobenzoyl
acetic acid
compound
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7682580A
Other languages
Japanese (ja)
Inventor
Hiroaki Kinugasa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Janssen Pharmaceuticals Inc
Original Assignee
Dainippon Pharmaceutical Co Ltd
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd, McNeilab Inc filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP7682580A priority Critical patent/JPS572268A/en
Priority to AT253381A priority patent/AT374176B/en
Priority to CA000379162A priority patent/CA1151189A/en
Publication of JPS572268A publication Critical patent/JPS572268A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the titled compound (general name:) useful as an analgesic and antiphlogistic agent, in shortened process and high yield, by heating 5-(p- chlorobenzoyl)-1,4-dimethyl-3-carboxypyrrole-2-acetic acid in the presence of a base.
CONSTITUTION: 5-( p-Chlorobenzoyl )-1, 4-dimethyl-3-carboxypyrrole- 2-acetic acid is heated in the presence of a base (e.g. sodium hydroxide, triethylamine, etc.) to afford 5-(p-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetic acid of formula V. The reaction temperature is about 140W230°C, pref. about 180W200°C. The compound of formula IV can be obtained by the hydrolysis of the diester of formula III obtained by the Friedel-Crafts reaction of the compound of formula I with the compound of formula II. The reaction can be continued to the main reaction without separating the compound of formula IV from the reaction mixture. Two reaction steps can be eliminated from the conventional process.
COPYRIGHT: (C)1982,JPO&Japio
JP7682580A 1980-06-06 1980-06-06 Preparation of 5- p-chlorobenzoyl -1,4-dimethylpyrrole- 2-acetic acid Pending JPS572268A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP7682580A JPS572268A (en) 1980-06-06 1980-06-06 Preparation of 5- p-chlorobenzoyl -1,4-dimethylpyrrole- 2-acetic acid
AT253381A AT374176B (en) 1980-06-06 1981-06-05 METHOD FOR PRODUCING 5- (P-CHLORBENZOYL) -1,4-DIMETHYLPYRROL-2-ACETIC ACID
CA000379162A CA1151189A (en) 1980-06-06 1981-06-05 Process for preparing: 5-(p-chlorobenzoyl)-1, 4- dimethylpyrrole-2-acetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7682580A JPS572268A (en) 1980-06-06 1980-06-06 Preparation of 5- p-chlorobenzoyl -1,4-dimethylpyrrole- 2-acetic acid

Publications (1)

Publication Number Publication Date
JPS572268A true JPS572268A (en) 1982-01-07

Family

ID=13616447

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7682580A Pending JPS572268A (en) 1980-06-06 1980-06-06 Preparation of 5- p-chlorobenzoyl -1,4-dimethylpyrrole- 2-acetic acid

Country Status (3)

Country Link
JP (1) JPS572268A (en)
AT (1) AT374176B (en)
CA (1) CA1151189A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0230110A1 (en) * 1985-11-30 1987-07-29 FISONS plc Pharmacologically active pyrrole and pyrazole derivatives

Also Published As

Publication number Publication date
ATA253381A (en) 1983-08-15
AT374176B (en) 1984-03-26
CA1151189A (en) 1983-08-02

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