JPS54141723A - Preparation of beta-hydroxyamino acid - Google Patents
Preparation of beta-hydroxyamino acidInfo
- Publication number
- JPS54141723A JPS54141723A JP4801978A JP4801978A JPS54141723A JP S54141723 A JPS54141723 A JP S54141723A JP 4801978 A JP4801978 A JP 4801978A JP 4801978 A JP4801978 A JP 4801978A JP S54141723 A JPS54141723 A JP S54141723A
- Authority
- JP
- Japan
- Prior art keywords
- base
- aldehyde
- isocyanoacetamide
- alkyl
- acid amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the title compound is high yield, by hydrolyzing oxazolinecarobxylic acid amide which can be obtained without side reactions, by reacting α-isocyanoacetamide with a specific aldehyde in the presence of a base.
CONSTITUTION: α-Isocyanoacetamide is made to react with an aldehyde I (both of the R1,2 are H, alkyl, or one on the R1 and R2 is H and the other is pyridyl, alkyl, etc.) or a ketone such as methyl ethyl ketone in the presence of a base to afford 5-substituted-2-oxazoline-4-carboxylic acid amide, which is to obtain the objective compound of formula III such as serine. The reaction is pref. carried out in a solvent, under cooling or heating. The base is an inorganic base such as alkali carbonate, alkali hydroxide, etc. When aldehyde is used as the reactant, a stereo specific compound having trans configulation can be synthesized.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4801978A JPS54141723A (en) | 1978-04-21 | 1978-04-21 | Preparation of beta-hydroxyamino acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4801978A JPS54141723A (en) | 1978-04-21 | 1978-04-21 | Preparation of beta-hydroxyamino acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54141723A true JPS54141723A (en) | 1979-11-05 |
Family
ID=12791590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4801978A Pending JPS54141723A (en) | 1978-04-21 | 1978-04-21 | Preparation of beta-hydroxyamino acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54141723A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0446798A1 (en) * | 1990-03-13 | 1991-09-18 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-alkyl-, 1-alkenyl- and 1-alkynylaryl-2-amino-1, 3-propanediols and related compounds, a process and intermediates for their preparation and their use as medicaments |
-
1978
- 1978-04-21 JP JP4801978A patent/JPS54141723A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0446798A1 (en) * | 1990-03-13 | 1991-09-18 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-alkyl-, 1-alkenyl- and 1-alkynylaryl-2-amino-1, 3-propanediols and related compounds, a process and intermediates for their preparation and their use as medicaments |
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