JPS54141723A - Preparation of beta-hydroxyamino acid - Google Patents

Preparation of beta-hydroxyamino acid

Info

Publication number
JPS54141723A
JPS54141723A JP4801978A JP4801978A JPS54141723A JP S54141723 A JPS54141723 A JP S54141723A JP 4801978 A JP4801978 A JP 4801978A JP 4801978 A JP4801978 A JP 4801978A JP S54141723 A JPS54141723 A JP S54141723A
Authority
JP
Japan
Prior art keywords
base
aldehyde
isocyanoacetamide
alkyl
acid amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4801978A
Other languages
Japanese (ja)
Inventor
Soji Miyoshi
Kazuo Matsumoto
Yasuhiko Ozaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP4801978A priority Critical patent/JPS54141723A/en
Publication of JPS54141723A publication Critical patent/JPS54141723A/en
Pending legal-status Critical Current

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  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound is high yield, by hydrolyzing oxazolinecarobxylic acid amide which can be obtained without side reactions, by reacting α-isocyanoacetamide with a specific aldehyde in the presence of a base.
CONSTITUTION: α-Isocyanoacetamide is made to react with an aldehyde I (both of the R1,2 are H, alkyl, or one on the R1 and R2 is H and the other is pyridyl, alkyl, etc.) or a ketone such as methyl ethyl ketone in the presence of a base to afford 5-substituted-2-oxazoline-4-carboxylic acid amide, which is to obtain the objective compound of formula III such as serine. The reaction is pref. carried out in a solvent, under cooling or heating. The base is an inorganic base such as alkali carbonate, alkali hydroxide, etc. When aldehyde is used as the reactant, a stereo specific compound having trans configulation can be synthesized.
COPYRIGHT: (C)1979,JPO&Japio
JP4801978A 1978-04-21 1978-04-21 Preparation of beta-hydroxyamino acid Pending JPS54141723A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4801978A JPS54141723A (en) 1978-04-21 1978-04-21 Preparation of beta-hydroxyamino acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4801978A JPS54141723A (en) 1978-04-21 1978-04-21 Preparation of beta-hydroxyamino acid

Publications (1)

Publication Number Publication Date
JPS54141723A true JPS54141723A (en) 1979-11-05

Family

ID=12791590

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4801978A Pending JPS54141723A (en) 1978-04-21 1978-04-21 Preparation of beta-hydroxyamino acid

Country Status (1)

Country Link
JP (1) JPS54141723A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0446798A1 (en) * 1990-03-13 1991-09-18 Hoechst-Roussel Pharmaceuticals Incorporated 1-alkyl-, 1-alkenyl- and 1-alkynylaryl-2-amino-1, 3-propanediols and related compounds, a process and intermediates for their preparation and their use as medicaments

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0446798A1 (en) * 1990-03-13 1991-09-18 Hoechst-Roussel Pharmaceuticals Incorporated 1-alkyl-, 1-alkenyl- and 1-alkynylaryl-2-amino-1, 3-propanediols and related compounds, a process and intermediates for their preparation and their use as medicaments

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