JPS57116032A - Preparation of alpha,beta-dehydro-alpha-amino acid ester - Google Patents

Preparation of alpha,beta-dehydro-alpha-amino acid ester

Info

Publication number
JPS57116032A
JPS57116032A JP364981A JP364981A JPS57116032A JP S57116032 A JPS57116032 A JP S57116032A JP 364981 A JP364981 A JP 364981A JP 364981 A JP364981 A JP 364981A JP S57116032 A JPS57116032 A JP S57116032A
Authority
JP
Japan
Prior art keywords
acid ester
alpha
compound
hydrogen chloride
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP364981A
Other languages
Japanese (ja)
Inventor
Soji Miyoshi
Naoto Yoneda
Kazuo Matsumoto
Tamon Moriya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP364981A priority Critical patent/JPS57116032A/en
Publication of JPS57116032A publication Critical patent/JPS57116032A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

PURPOSE: To prepare the titled substance useful as a substrate for biosynthesis, under mild conditions, in high yield, by using an easily available α-formamidoacrylic acid ester compound as a raw material, and selectively hydrolyzing the formamide group of the compound with hydrogen chloride in a solvent.
CONSTITUTION: The compound of formula II (R1 and R2 are H, alkyl, aryl or heterocyclic group; R3 is alkyl) can be prepared by treating the α-formamidoacrylic acid ester compound of formulaIwith hydrogen chloride in an alkanol or a mixture of an alkanol and an aprotic solvent at -10W+50°C. The concentration of hydrogen chloride is pref. 0.1W40W/V%, esp. 1W35W/V%, based on the whole volume of the solvent. The starting compound of formulaIcan be obtained by condensing, e.g. an α-isocyanoacetic acid ester with an aldehyde in the presence of a basic catalyst.
COPYRIGHT: (C)1982,JPO&Japio
JP364981A 1981-01-12 1981-01-12 Preparation of alpha,beta-dehydro-alpha-amino acid ester Pending JPS57116032A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP364981A JPS57116032A (en) 1981-01-12 1981-01-12 Preparation of alpha,beta-dehydro-alpha-amino acid ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP364981A JPS57116032A (en) 1981-01-12 1981-01-12 Preparation of alpha,beta-dehydro-alpha-amino acid ester

Publications (1)

Publication Number Publication Date
JPS57116032A true JPS57116032A (en) 1982-07-19

Family

ID=11563319

Family Applications (1)

Application Number Title Priority Date Filing Date
JP364981A Pending JPS57116032A (en) 1981-01-12 1981-01-12 Preparation of alpha,beta-dehydro-alpha-amino acid ester

Country Status (1)

Country Link
JP (1) JPS57116032A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111825594A (en) * 2020-08-18 2020-10-27 商丘师范学院 (Z) -beta-trifluoromethyl dehydrotryptophan compound and synthetic method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111825594A (en) * 2020-08-18 2020-10-27 商丘师范学院 (Z) -beta-trifluoromethyl dehydrotryptophan compound and synthetic method and application thereof

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