JPS57116032A - Preparation of alpha,beta-dehydro-alpha-amino acid ester - Google Patents
Preparation of alpha,beta-dehydro-alpha-amino acid esterInfo
- Publication number
- JPS57116032A JPS57116032A JP364981A JP364981A JPS57116032A JP S57116032 A JPS57116032 A JP S57116032A JP 364981 A JP364981 A JP 364981A JP 364981 A JP364981 A JP 364981A JP S57116032 A JPS57116032 A JP S57116032A
- Authority
- JP
- Japan
- Prior art keywords
- acid ester
- alpha
- compound
- hydrogen chloride
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
PURPOSE: To prepare the titled substance useful as a substrate for biosynthesis, under mild conditions, in high yield, by using an easily available α-formamidoacrylic acid ester compound as a raw material, and selectively hydrolyzing the formamide group of the compound with hydrogen chloride in a solvent.
CONSTITUTION: The compound of formula II (R1 and R2 are H, alkyl, aryl or heterocyclic group; R3 is alkyl) can be prepared by treating the α-formamidoacrylic acid ester compound of formulaIwith hydrogen chloride in an alkanol or a mixture of an alkanol and an aprotic solvent at -10W+50°C. The concentration of hydrogen chloride is pref. 0.1W40W/V%, esp. 1W35W/V%, based on the whole volume of the solvent. The starting compound of formulaIcan be obtained by condensing, e.g. an α-isocyanoacetic acid ester with an aldehyde in the presence of a basic catalyst.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP364981A JPS57116032A (en) | 1981-01-12 | 1981-01-12 | Preparation of alpha,beta-dehydro-alpha-amino acid ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP364981A JPS57116032A (en) | 1981-01-12 | 1981-01-12 | Preparation of alpha,beta-dehydro-alpha-amino acid ester |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57116032A true JPS57116032A (en) | 1982-07-19 |
Family
ID=11563319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP364981A Pending JPS57116032A (en) | 1981-01-12 | 1981-01-12 | Preparation of alpha,beta-dehydro-alpha-amino acid ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57116032A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111825594A (en) * | 2020-08-18 | 2020-10-27 | 商丘师范学院 | (Z) -beta-trifluoromethyl dehydrotryptophan compound and synthetic method and application thereof |
-
1981
- 1981-01-12 JP JP364981A patent/JPS57116032A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111825594A (en) * | 2020-08-18 | 2020-10-27 | 商丘师范学院 | (Z) -beta-trifluoromethyl dehydrotryptophan compound and synthetic method and application thereof |
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