JPS57154164A - Preparation of dl-cysteine or cystine - Google Patents

Preparation of dl-cysteine or cystine

Info

Publication number
JPS57154164A
JPS57154164A JP3647681A JP3647681A JPS57154164A JP S57154164 A JPS57154164 A JP S57154164A JP 3647681 A JP3647681 A JP 3647681A JP 3647681 A JP3647681 A JP 3647681A JP S57154164 A JPS57154164 A JP S57154164A
Authority
JP
Japan
Prior art keywords
acid
thiazoline
reaction
solvent
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3647681A
Other languages
Japanese (ja)
Other versions
JPS585194B2 (en
Inventor
Wataru Ando
Haruo Miyasaka
Keizo Tomuro
Yoshiharu Tamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIHON RIKAGAKU YAKUHIN KK
NIPPON RIKAGAKU YAKUHIN KK
Original Assignee
NIHON RIKAGAKU YAKUHIN KK
NIPPON RIKAGAKU YAKUHIN KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIHON RIKAGAKU YAKUHIN KK, NIPPON RIKAGAKU YAKUHIN KK filed Critical NIHON RIKAGAKU YAKUHIN KK
Priority to JP3647681A priority Critical patent/JPS585194B2/en
Publication of JPS57154164A publication Critical patent/JPS57154164A/en
Publication of JPS585194B2 publication Critical patent/JPS585194B2/en
Expired legal-status Critical Current

Links

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the titled sulfur-containing amino acid, economically, in an industrial scale, in high yield, by hydrolyzing the 2-substituted thiazoline-4-carboxylic acid obtained by the reaction of an α-haloacrylic acid ester with a thioamide using acetic acid or formic acid as the reaction solvent.
CONSTITUTION: The α-haloacrylic acid ester of formulaI(X is Cl or Br; R is methyl or ethyl) and the thioamide compound of formula II (R' is methyl, ethyl or phenyl) are subjected to the thiazoline-ring forming reaction using acetic acid or formic acid as the solvent to afford 2-substituted thiazoline-4- carboxylic acid or its derivative, which is hydrolyzed to obtain DL-cysteine or optically inactive cystine. The process is also extremely advantageous in view of the raw materials, because the proper selection of the solvent for the reaction of the compounds of formulaIand formula II enables the preparation of the easily hydrolyzable 2-substituted thiazoline-4-carboxylic acid and the formation of its thiazoline ring.
COPYRIGHT: (C)1982,JPO&Japio
JP3647681A 1981-03-16 1981-03-16 Method for producing DL-cysteine or cystine Expired JPS585194B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3647681A JPS585194B2 (en) 1981-03-16 1981-03-16 Method for producing DL-cysteine or cystine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3647681A JPS585194B2 (en) 1981-03-16 1981-03-16 Method for producing DL-cysteine or cystine

Publications (2)

Publication Number Publication Date
JPS57154164A true JPS57154164A (en) 1982-09-22
JPS585194B2 JPS585194B2 (en) 1983-01-29

Family

ID=12470862

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3647681A Expired JPS585194B2 (en) 1981-03-16 1981-03-16 Method for producing DL-cysteine or cystine

Country Status (1)

Country Link
JP (1) JPS585194B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004149426A (en) * 2002-10-29 2004-05-27 Takeda Chem Ind Ltd L-cysteine-containing solid pharmaceutical preparation and method for stabilizing the same

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60167077A (en) * 1984-02-09 1985-08-30 Toshiba Corp Pulse signal integration device
JPH01227917A (en) * 1988-03-08 1989-09-12 Yokogawa Electric Corp Azimuth measuring instrument switching system

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004149426A (en) * 2002-10-29 2004-05-27 Takeda Chem Ind Ltd L-cysteine-containing solid pharmaceutical preparation and method for stabilizing the same

Also Published As

Publication number Publication date
JPS585194B2 (en) 1983-01-29

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