JPS57154164A - Preparation of dl-cysteine or cystine - Google Patents
Preparation of dl-cysteine or cystineInfo
- Publication number
- JPS57154164A JPS57154164A JP3647681A JP3647681A JPS57154164A JP S57154164 A JPS57154164 A JP S57154164A JP 3647681 A JP3647681 A JP 3647681A JP 3647681 A JP3647681 A JP 3647681A JP S57154164 A JPS57154164 A JP S57154164A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- thiazoline
- reaction
- solvent
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled sulfur-containing amino acid, economically, in an industrial scale, in high yield, by hydrolyzing the 2-substituted thiazoline-4-carboxylic acid obtained by the reaction of an α-haloacrylic acid ester with a thioamide using acetic acid or formic acid as the reaction solvent.
CONSTITUTION: The α-haloacrylic acid ester of formulaI(X is Cl or Br; R is methyl or ethyl) and the thioamide compound of formula II (R' is methyl, ethyl or phenyl) are subjected to the thiazoline-ring forming reaction using acetic acid or formic acid as the solvent to afford 2-substituted thiazoline-4- carboxylic acid or its derivative, which is hydrolyzed to obtain DL-cysteine or optically inactive cystine. The process is also extremely advantageous in view of the raw materials, because the proper selection of the solvent for the reaction of the compounds of formulaIand formula II enables the preparation of the easily hydrolyzable 2-substituted thiazoline-4-carboxylic acid and the formation of its thiazoline ring.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3647681A JPS585194B2 (en) | 1981-03-16 | 1981-03-16 | Method for producing DL-cysteine or cystine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3647681A JPS585194B2 (en) | 1981-03-16 | 1981-03-16 | Method for producing DL-cysteine or cystine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57154164A true JPS57154164A (en) | 1982-09-22 |
JPS585194B2 JPS585194B2 (en) | 1983-01-29 |
Family
ID=12470862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3647681A Expired JPS585194B2 (en) | 1981-03-16 | 1981-03-16 | Method for producing DL-cysteine or cystine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS585194B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004149426A (en) * | 2002-10-29 | 2004-05-27 | Takeda Chem Ind Ltd | L-cysteine-containing solid pharmaceutical preparation and method for stabilizing the same |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60167077A (en) * | 1984-02-09 | 1985-08-30 | Toshiba Corp | Pulse signal integration device |
JPH01227917A (en) * | 1988-03-08 | 1989-09-12 | Yokogawa Electric Corp | Azimuth measuring instrument switching system |
-
1981
- 1981-03-16 JP JP3647681A patent/JPS585194B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004149426A (en) * | 2002-10-29 | 2004-05-27 | Takeda Chem Ind Ltd | L-cysteine-containing solid pharmaceutical preparation and method for stabilizing the same |
Also Published As
Publication number | Publication date |
---|---|
JPS585194B2 (en) | 1983-01-29 |
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