JPS5479248A - (2s, 3r)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid - Google Patents

(2s, 3r)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid

Info

Publication number
JPS5479248A
JPS5479248A JP11559278A JP11559278A JPS5479248A JP S5479248 A JPS5479248 A JP S5479248A JP 11559278 A JP11559278 A JP 11559278A JP 11559278 A JP11559278 A JP 11559278A JP S5479248 A JPS5479248 A JP S5479248A
Authority
JP
Japan
Prior art keywords
amino
hydroxy
acid
hydroxyphenylbutyric
hydroxyphenylbutyric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11559278A
Other languages
Japanese (ja)
Other versions
JPS6039263B2 (en
Inventor
Hamao Umezawa
Takaaki Aoyanagi
Tomohisa Takita
Rinzo Nishizawa
Tetsuyuki Saino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP11559278A priority Critical patent/JPS6039263B2/en
Publication of JPS5479248A publication Critical patent/JPS5479248A/en
Publication of JPS6039263B2 publication Critical patent/JPS6039263B2/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:(2S,3R)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid or its salts.
USE: Starting material of (2S,3R)-3-amino-2-hydroxy-4-p-hydroxyphenylbutanoyl- (S)-leucine having good inhibition activity against aminopeptidase-B.
PREPARATION: A nitrile derivative of formula II (groups protecting amino group are preferably acyl ones as formyl or acethyl) is hydrolyzed in the presence of an acid as hydrochloric or sulfuric acid to prepare the corresponding carboxylic acid, which is optically resolved by a conventional method to yield the compound of formulaI.
COPYRIGHT: (C)1979,JPO&Japio
JP11559278A 1978-09-20 1978-09-20 (2S,3R)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid Expired JPS6039263B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11559278A JPS6039263B2 (en) 1978-09-20 1978-09-20 (2S,3R)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11559278A JPS6039263B2 (en) 1978-09-20 1978-09-20 (2S,3R)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP7336677A Division JPS5936902B2 (en) 1977-06-22 1977-06-22 (2S,3R)-3-amino-2-hydroxy-4-P-hydroxyphenylbutanoyl-(S)-leucine and its production method

Publications (2)

Publication Number Publication Date
JPS5479248A true JPS5479248A (en) 1979-06-25
JPS6039263B2 JPS6039263B2 (en) 1985-09-05

Family

ID=14666411

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11559278A Expired JPS6039263B2 (en) 1978-09-20 1978-09-20 (2S,3R)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid

Country Status (1)

Country Link
JP (1) JPS6039263B2 (en)

Also Published As

Publication number Publication date
JPS6039263B2 (en) 1985-09-05

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