JPS5479248A - (2s, 3r)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid - Google Patents
(2s, 3r)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acidInfo
- Publication number
- JPS5479248A JPS5479248A JP11559278A JP11559278A JPS5479248A JP S5479248 A JPS5479248 A JP S5479248A JP 11559278 A JP11559278 A JP 11559278A JP 11559278 A JP11559278 A JP 11559278A JP S5479248 A JPS5479248 A JP S5479248A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- hydroxy
- acid
- hydroxyphenylbutyric
- hydroxyphenylbutyric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:(2S,3R)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid or its salts.
USE: Starting material of (2S,3R)-3-amino-2-hydroxy-4-p-hydroxyphenylbutanoyl- (S)-leucine having good inhibition activity against aminopeptidase-B.
PREPARATION: A nitrile derivative of formula II (groups protecting amino group are preferably acyl ones as formyl or acethyl) is hydrolyzed in the presence of an acid as hydrochloric or sulfuric acid to prepare the corresponding carboxylic acid, which is optically resolved by a conventional method to yield the compound of formulaI.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11559278A JPS6039263B2 (en) | 1978-09-20 | 1978-09-20 | (2S,3R)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11559278A JPS6039263B2 (en) | 1978-09-20 | 1978-09-20 | (2S,3R)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7336677A Division JPS5936902B2 (en) | 1977-06-22 | 1977-06-22 | (2S,3R)-3-amino-2-hydroxy-4-P-hydroxyphenylbutanoyl-(S)-leucine and its production method |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5479248A true JPS5479248A (en) | 1979-06-25 |
JPS6039263B2 JPS6039263B2 (en) | 1985-09-05 |
Family
ID=14666411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11559278A Expired JPS6039263B2 (en) | 1978-09-20 | 1978-09-20 | (2S,3R)-3-amino-2-hydroxy-4-p-hydroxyphenylbutyric acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6039263B2 (en) |
-
1978
- 1978-09-20 JP JP11559278A patent/JPS6039263B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6039263B2 (en) | 1985-09-05 |
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