JPS5753458A - Preparation of mercaptoamine - Google Patents
Preparation of mercaptoamineInfo
- Publication number
- JPS5753458A JPS5753458A JP12795080A JP12795080A JPS5753458A JP S5753458 A JPS5753458 A JP S5753458A JP 12795080 A JP12795080 A JP 12795080A JP 12795080 A JP12795080 A JP 12795080A JP S5753458 A JPS5753458 A JP S5753458A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- expressed
- mercaptoamine
- aminoethylthio
- thiazolidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain a mercaptoamine useful as a raw material for medicines, etc. esily in high purity and yield, by hydrolyzing a 2-(2'-aminoethylthio)-2-thiazolidine dihydrohalide derivative with a hydrohalogenic acid.
CONSTITUTION: A 2-(2'-aminoethylthio)-2-thiazolidine dihydrohalide derivative, e.g. 2-(2'-aminoethylthio)-2-thiazolidine dihydrobromide, expressed by formula I (R1, R2, R3 and R4 are H or lower alkyl; X is halogen) is hydrolyzed with a hydrohalogenic acid, e.g. ≥15% hydrochloric acid, to give a mercaptoamine expressed by formula II. The reaction is carried out at 50°C or above for 3W90hr, and the amount of the hydrohalogenic acid to be used is 1/2W20 molar equivalents based on the compound expressed by formula I. Toxic H2S or by-products which are not easily separated are not formed. The compound expressed by formula I can be obtained quantitatively by reacting a compound expressed by formula III with a compound expressed by formula IV.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12795080A JPS6050187B2 (en) | 1980-09-17 | 1980-09-17 | Method for producing mercaptoamines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12795080A JPS6050187B2 (en) | 1980-09-17 | 1980-09-17 | Method for producing mercaptoamines |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5753458A true JPS5753458A (en) | 1982-03-30 |
JPS6050187B2 JPS6050187B2 (en) | 1985-11-07 |
Family
ID=14972643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12795080A Expired JPS6050187B2 (en) | 1980-09-17 | 1980-09-17 | Method for producing mercaptoamines |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6050187B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH029071U (en) * | 1988-07-02 | 1990-01-22 | ||
US5256362A (en) * | 1989-07-14 | 1993-10-26 | Nippon Shokubai Co., Ltd. | Method for production of granular cysteamine hydrochloride |
-
1980
- 1980-09-17 JP JP12795080A patent/JPS6050187B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH029071U (en) * | 1988-07-02 | 1990-01-22 | ||
US5256362A (en) * | 1989-07-14 | 1993-10-26 | Nippon Shokubai Co., Ltd. | Method for production of granular cysteamine hydrochloride |
Also Published As
Publication number | Publication date |
---|---|
JPS6050187B2 (en) | 1985-11-07 |
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