JPS5753458A - Preparation of mercaptoamine - Google Patents

Preparation of mercaptoamine

Info

Publication number
JPS5753458A
JPS5753458A JP12795080A JP12795080A JPS5753458A JP S5753458 A JPS5753458 A JP S5753458A JP 12795080 A JP12795080 A JP 12795080A JP 12795080 A JP12795080 A JP 12795080A JP S5753458 A JPS5753458 A JP S5753458A
Authority
JP
Japan
Prior art keywords
formula
expressed
mercaptoamine
aminoethylthio
thiazolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12795080A
Other languages
Japanese (ja)
Other versions
JPS6050187B2 (en
Inventor
Isamu Yamamoto
Eiichi Noda
Yoshiaki Noguchi
Shigenobu Nakayama
Noboru Kawasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP12795080A priority Critical patent/JPS6050187B2/ja
Publication of JPS5753458A publication Critical patent/JPS5753458A/en
Publication of JPS6050187B2 publication Critical patent/JPS6050187B2/ja
Expired legal-status Critical Current

Links

Abstract

PURPOSE: To obtain a mercaptoamine useful as a raw material for medicines, etc. esily in high purity and yield, by hydrolyzing a 2-(2'-aminoethylthio)-2-thiazolidine dihydrohalide derivative with a hydrohalogenic acid.
CONSTITUTION: A 2-(2'-aminoethylthio)-2-thiazolidine dihydrohalide derivative, e.g. 2-(2'-aminoethylthio)-2-thiazolidine dihydrobromide, expressed by formula I (R1, R2, R3 and R4 are H or lower alkyl; X is halogen) is hydrolyzed with a hydrohalogenic acid, e.g. ≥15% hydrochloric acid, to give a mercaptoamine expressed by formula II. The reaction is carried out at 50°C or above for 3W90hr, and the amount of the hydrohalogenic acid to be used is 1/2W20 molar equivalents based on the compound expressed by formula I. Toxic H2S or by-products which are not easily separated are not formed. The compound expressed by formula I can be obtained quantitatively by reacting a compound expressed by formula III with a compound expressed by formula IV.
COPYRIGHT: (C)1982,JPO&Japio
JP12795080A 1980-09-17 1980-09-17 Expired JPS6050187B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12795080A JPS6050187B2 (en) 1980-09-17 1980-09-17

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12795080A JPS6050187B2 (en) 1980-09-17 1980-09-17

Publications (2)

Publication Number Publication Date
JPS5753458A true JPS5753458A (en) 1982-03-30
JPS6050187B2 JPS6050187B2 (en) 1985-11-07

Family

ID=14972643

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12795080A Expired JPS6050187B2 (en) 1980-09-17 1980-09-17

Country Status (1)

Country Link
JP (1) JPS6050187B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH029071U (en) * 1988-07-02 1990-01-22
US5256362A (en) * 1989-07-14 1993-10-26 Nippon Shokubai Co., Ltd. Method for production of granular cysteamine hydrochloride

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH029071U (en) * 1988-07-02 1990-01-22
US5256362A (en) * 1989-07-14 1993-10-26 Nippon Shokubai Co., Ltd. Method for production of granular cysteamine hydrochloride

Also Published As

Publication number Publication date
JPS6050187B2 (en) 1985-11-07

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