JPS54106457A - 2-azetidinone derivative and its preparation - Google Patents
2-azetidinone derivative and its preparationInfo
- Publication number
- JPS54106457A JPS54106457A JP1379178A JP1379178A JPS54106457A JP S54106457 A JPS54106457 A JP S54106457A JP 1379178 A JP1379178 A JP 1379178A JP 1379178 A JP1379178 A JP 1379178A JP S54106457 A JPS54106457 A JP S54106457A
- Authority
- JP
- Japan
- Prior art keywords
- aralkyl
- alkyl
- alkenyl
- aryl
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound I (R1 is H, OH, alkoxy, amino, etc.; R2 is alkyl, aralkyl; R3 is alkyl, aryl, aralkyl, alkenyl, alkynyl, etc.; R4 is alkyl, alkenyl, aryl, aralkyl.).
EXAMPLE: (4S)-t-butyl-α-(4-benzyloxycarbonyl-2-oxoazetidin-1-yl)-α-(acetyl) acetamide.
USE: β-Lactamase-inhibiting agent which is expected to be useful as a remedy for infectious diseases by using together with an antibiotic such as penicillin, etc. It is also useful as a synthetic intermediate of a sleleton of β-lactamase antibiotics.
PROCESS: The compound I is prepared by reacting an aspartic acid derivative II with an aldehyde III and an isonitrile IV in an inert solvent at +150W-50°C, pref. 0W50°C.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1379178A JPS54106457A (en) | 1978-02-09 | 1978-02-09 | 2-azetidinone derivative and its preparation |
CA000312398A CA1145347A (en) | 1977-09-30 | 1978-09-29 | 2-azetidinone derivatives |
FR7827889A FR2404632A1 (en) | 1977-09-30 | 1978-09-29 | NEW AZETIDINONE DERIVATIVES AND THEIR MANUFACTURING PROCEDURES |
GB7838626A GB2006195B (en) | 1977-09-30 | 1978-09-29 | 2-azetidinone derivatives |
DE19782842466 DE2842466A1 (en) | 1977-09-30 | 1978-09-29 | 2-AZETIDINONE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
US06/142,542 US4322345A (en) | 1977-09-30 | 1980-04-21 | 2-Azetidinone 4-carboxy derivatives and a process for producing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1379178A JPS54106457A (en) | 1978-02-09 | 1978-02-09 | 2-azetidinone derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54106457A true JPS54106457A (en) | 1979-08-21 |
Family
ID=11843064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1379178A Pending JPS54106457A (en) | 1977-09-30 | 1978-02-09 | 2-azetidinone derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54106457A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006308097A (en) * | 2005-04-29 | 2006-11-09 | Sulzer Pumpen Ag | Flow machine and its sliding ring seal, sliding ring seal body component, and method of fastening sliding ring seal to flow machine |
-
1978
- 1978-02-09 JP JP1379178A patent/JPS54106457A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006308097A (en) * | 2005-04-29 | 2006-11-09 | Sulzer Pumpen Ag | Flow machine and its sliding ring seal, sliding ring seal body component, and method of fastening sliding ring seal to flow machine |
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