JPS5711962A - Preparation of beta-lactam derivative - Google Patents

Preparation of beta-lactam derivative

Info

Publication number
JPS5711962A
JPS5711962A JP16290180A JP16290180A JPS5711962A JP S5711962 A JPS5711962 A JP S5711962A JP 16290180 A JP16290180 A JP 16290180A JP 16290180 A JP16290180 A JP 16290180A JP S5711962 A JPS5711962 A JP S5711962A
Authority
JP
Japan
Prior art keywords
lactam derivative
lactam
derivative
nitrite
mono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16290180A
Other languages
Japanese (ja)
Other versions
JPH0147467B2 (en
Inventor
Makoto Sunakawa
Haruki Matsumura
Takaaki Inoue
Toshiyuki Hirohashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of JPS5711962A publication Critical patent/JPS5711962A/en
Publication of JPH0147467B2 publication Critical patent/JPH0147467B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To obtain an N-unsubstituted derivative useful as a synthetic intermediate for a β-lactam antimicrobial agent in high yield and readily, by reacting an N-mono- or diarylmethyl substituted β-lactam derivative with ammonium ceric nitrite.
CONSTITUTION: A β-lactam derivative of formula I [R1 is H, amino, amido, etc.; R2 is H or lower alkyl; R3 is carboxyl, lower alkoxycarbonyl, etc.; R is mono- or diarylmethyl [e.g. 2,4-dimethoxybenzyl or di(4-methoxyphenyl)methyl]] is reacted with ammonium ceric nitrite to cleave the N-mono- or N-diarylmethyl bond and give an N-unsubstituted β-lactam derivative of formula II. The reaction is carried out in an inert solvent, e.g. DMF, and the molar amount of the ammonium ceric nitrite to be used is 2W3 times that of the β-lactam derivative. The reaction temperature is preferably 0W100°C.
COPYRIGHT: (C)1982,JPO&Japio
JP16290180A 1980-06-25 1980-11-18 Preparation of beta-lactam derivative Granted JPS5711962A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA354817 1980-06-25

Publications (2)

Publication Number Publication Date
JPS5711962A true JPS5711962A (en) 1982-01-21
JPH0147467B2 JPH0147467B2 (en) 1989-10-13

Family

ID=4117268

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16290180A Granted JPS5711962A (en) 1980-06-25 1980-11-18 Preparation of beta-lactam derivative

Country Status (1)

Country Link
JP (1) JPS5711962A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5692693A (en) * 1994-04-01 1997-12-02 Daiwa Seiko, Inc. Backflash preventive device for preventing over rotation of a spool for a fishing reel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5692693A (en) * 1994-04-01 1997-12-02 Daiwa Seiko, Inc. Backflash preventive device for preventing over rotation of a spool for a fishing reel

Also Published As

Publication number Publication date
JPH0147467B2 (en) 1989-10-13

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