JPS567758A - Preparation of beta-lactam derivative - Google Patents

Preparation of beta-lactam derivative

Info

Publication number
JPS567758A
JPS567758A JP8241179A JP8241179A JPS567758A JP S567758 A JPS567758 A JP S567758A JP 8241179 A JP8241179 A JP 8241179A JP 8241179 A JP8241179 A JP 8241179A JP S567758 A JPS567758 A JP S567758A
Authority
JP
Japan
Prior art keywords
nitrogen atom
lactam
mono
derivative
diarylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8241179A
Other languages
Japanese (ja)
Inventor
Jun Sunakawa
Haruki Matsumura
Takaaki Inoue
Toshiyuki Hirohashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP8241179A priority Critical patent/JPS567758A/en
Priority to US06/164,396 priority patent/US4536334A/en
Priority to DE8080302197T priority patent/DE3068790D1/en
Priority to EP80302197A priority patent/EP0023097B1/en
Publication of JPS567758A publication Critical patent/JPS567758A/en
Pending legal-status Critical Current

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  • Hydrogenated Pyridines (AREA)

Abstract

PURPOSE: To prepare the titled compound, having an unsubstituted nitrogen atom in β-lactam ring and useful as an intermediate of antibacterials, easily, without using an oxidizing agent, by the reaction of a β-lactam derivative having mono- or diarylmethyl group on the nitrogen atom in the β-lactam ring with an acid.
CONSTITUTION: A derivative of β-lactam having a β-lactam ring nitrogen atom substituted with mono- or diarylmethyl group, e.g. a compound of the formula [R is mono- or diarylmethyl (e.g. 2,4-dimethoxybenzyl); R1 is H, arylthio, etc.; R2 is H or lower alkyl; R3 is lower alkoxycarbonyl, etc.] is made to react with an acid, e.g. trifluoroacetic acid, to open the bond between the nitrogen atom and the mono- or diarylmethyl group and to afford the objective β-lactam derivative (a compound of the formula wherein R is H) having a hydrogen atom on the nitrogen atom. The process can easily be performed without using an oxidizing agent, and is applicable to a wide variety of syntheses.
COPYRIGHT: (C)1981,JPO&Japio
JP8241179A 1979-06-28 1979-06-28 Preparation of beta-lactam derivative Pending JPS567758A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP8241179A JPS567758A (en) 1979-06-28 1979-06-28 Preparation of beta-lactam derivative
US06/164,396 US4536334A (en) 1979-06-28 1980-06-30 Preparation of β-lactam derivatives
DE8080302197T DE3068790D1 (en) 1979-06-28 1980-06-30 De-arylmethylation of n-mono- or n-diarylmethyl-beta-lactams; novel azetizinones having anti-bacterial activity
EP80302197A EP0023097B1 (en) 1979-06-28 1980-06-30 De-arylmethylation of n-mono- or n-diarylmethyl-beta-lactams; novel azetizinones having anti-bacterial activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8241179A JPS567758A (en) 1979-06-28 1979-06-28 Preparation of beta-lactam derivative

Publications (1)

Publication Number Publication Date
JPS567758A true JPS567758A (en) 1981-01-27

Family

ID=13773838

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8241179A Pending JPS567758A (en) 1979-06-28 1979-06-28 Preparation of beta-lactam derivative

Country Status (1)

Country Link
JP (1) JPS567758A (en)

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