JPS5758690A - Preparation of 7-amino-7alpha-methoxycephem compound - Google Patents

Preparation of 7-amino-7alpha-methoxycephem compound

Info

Publication number
JPS5758690A
JPS5758690A JP55132291A JP13229180A JPS5758690A JP S5758690 A JPS5758690 A JP S5758690A JP 55132291 A JP55132291 A JP 55132291A JP 13229180 A JP13229180 A JP 13229180A JP S5758690 A JPS5758690 A JP S5758690A
Authority
JP
Japan
Prior art keywords
acid
compound
methoxycephem
compound shown
methanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55132291A
Other languages
Japanese (ja)
Inventor
Yasuo Hoshiide
Kenichi Suzuki
Takeji Seki
Nariyuki Tasaka
Hirosuke Niwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Original Assignee
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIKKEN KAGAKU KK, Nikken Chemicals Co Ltd filed Critical NIKKEN KAGAKU KK
Priority to JP55132291A priority Critical patent/JPS5758690A/en
Publication of JPS5758690A publication Critical patent/JPS5758690A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: To obtain the titled compound useful as an intermediate for a 7-α-methoxycephem type compound having strong resistance to β-lactamase, by decomposing a specific 7-methoxycephem compound in the presence of an acid in methanol.
CONSTITUTION: A 7-methoxycephem compound shown by the formulaIR1 and R2 are carboxylic acid-protecting group; Z is organic or inorganic group residue) is decomposed in the presence of an acid in methanol, to give a 7-amino-7α-emthoxycephem compound shown by the formula II. A strong acid, e.g., sulfuric acid, hydrochloric acid, etc. is used as the acid. The decomposition is carried out at a temperature cooling with iceW-30°C, preferably at cooling with iceW-10°C. The compound shown by the formulaIcan be obtained by reacting a compound shown by the formula III with methanol in the presence of an N-halogenoimide and borate.
COPYRIGHT: (C)1982,JPO&Japio
JP55132291A 1980-09-25 1980-09-25 Preparation of 7-amino-7alpha-methoxycephem compound Pending JPS5758690A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55132291A JPS5758690A (en) 1980-09-25 1980-09-25 Preparation of 7-amino-7alpha-methoxycephem compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55132291A JPS5758690A (en) 1980-09-25 1980-09-25 Preparation of 7-amino-7alpha-methoxycephem compound

Publications (1)

Publication Number Publication Date
JPS5758690A true JPS5758690A (en) 1982-04-08

Family

ID=15077847

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55132291A Pending JPS5758690A (en) 1980-09-25 1980-09-25 Preparation of 7-amino-7alpha-methoxycephem compound

Country Status (1)

Country Link
JP (1) JPS5758690A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61240175A (en) * 1985-04-17 1986-10-25 Hitachi Electronics Eng Co Ltd Ic inspection system
US5552542A (en) * 1995-05-10 1996-09-03 Bristol-Myers Squibb Company Preparation and use of 7-[(2-carboalkoxy-1-methylethenyl)amino]-3-hydroxymethyl-3-cephem-4-carboxylic acids

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61240175A (en) * 1985-04-17 1986-10-25 Hitachi Electronics Eng Co Ltd Ic inspection system
US5552542A (en) * 1995-05-10 1996-09-03 Bristol-Myers Squibb Company Preparation and use of 7-[(2-carboalkoxy-1-methylethenyl)amino]-3-hydroxymethyl-3-cephem-4-carboxylic acids
EP0742219A1 (en) * 1995-05-10 1996-11-13 Bristol-Myers Squibb Company Preparation and use of 7-((2-carbo-alkoxy-1-methylethenyl) amino)-3-hydroxymethyl-3-cephem-4-carboxylic acids
US5637694A (en) * 1995-05-10 1997-06-10 Briston-Myers Squibb Company Preparation and use of 7-[(2-carboalkoxy-1-methylethenyl)amino]-3-hydroxymethyl-3-cephem-4-carboxylic acids
CN1055692C (en) * 1995-05-10 2000-08-23 布里斯托尔-米尔斯·斯奎布公司 Prepn. and use of 7-[(2-carboalkoxy-1-methylethenyl) amino]-3-hydroxymethyl-3-cephem-4-cargoxylic acids

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