JPS57209292A - Preparation of 7-aminocephem compound - Google Patents

Preparation of 7-aminocephem compound

Info

Publication number
JPS57209292A
JPS57209292A JP9329381A JP9329381A JPS57209292A JP S57209292 A JPS57209292 A JP S57209292A JP 9329381 A JP9329381 A JP 9329381A JP 9329381 A JP9329381 A JP 9329381A JP S57209292 A JPS57209292 A JP S57209292A
Authority
JP
Japan
Prior art keywords
compound
acid
preparation
methyl
thiol compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9329381A
Other languages
Japanese (ja)
Other versions
JPH0161112B2 (en
Inventor
Kenzo Naito
Haruo Niura
Kazuo Tsukamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP9329381A priority Critical patent/JPS57209292A/en
Priority to DE8181109233T priority patent/DE3173529D1/en
Priority to EP81109233A priority patent/EP0051824B1/en
Priority to AT81109233T priority patent/ATE17489T1/en
Priority to CA000389499A priority patent/CA1169419A/en
Priority to US06/318,960 priority patent/US4446318A/en
Priority to HU813356A priority patent/HU185977B/en
Priority to ES506970A priority patent/ES8206535A1/en
Priority to KR1019810004330A priority patent/KR870001985B1/en
Publication of JPS57209292A publication Critical patent/JPS57209292A/en
Publication of JPH0161112B2 publication Critical patent/JPH0161112B2/ja
Granted legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To prepare the titled compound (ester at 4-position) useful as an important intermediate for the preparation of antibiotic substances, in high yield and quality, by reacting a specific compound with a thiol compound in a solvent in the presence of a dihalophosphoric acid.
CONSTITUTION: 1Mole of the compound of formulaI(R1 is H or methoxy; R is carboxylic acid acyl)(e.g. 7-aminocephalosporanic acid) is mixed with 1.5mol of a thiol compound (e.g. 5-mercapto-1-methyl-1H-tetrazole) in an organic solvent (e.g. acetonitrile), and 4W16mol of a dihalophosphoric acid (e.g. dichlorophosphoric acid) is added to the mixture under cooling at -40W+30°C. The mixture is heated to 0W70°C and subjected to salting-out, etc. to obtain the objective compound of formula II (R2 is residue of thiol compound)[e.g. 7-amino-3-(1- methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid].
COPYRIGHT: (C)1982,JPO&Japio
JP9329381A 1980-11-11 1981-06-17 Preparation of 7-aminocephem compound Granted JPS57209292A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP9329381A JPS57209292A (en) 1981-06-17 1981-06-17 Preparation of 7-aminocephem compound
DE8181109233T DE3173529D1 (en) 1980-11-11 1981-10-29 Improvement in the method for producing 7-aminocephem compounds
EP81109233A EP0051824B1 (en) 1980-11-11 1981-10-29 Improvement in the method for producing 7-aminocephem compounds
AT81109233T ATE17489T1 (en) 1980-11-11 1981-10-29 PROCESSES FOR THE PREPARATION OF 7-AMINOCEPHEM COMPOUNDS.
CA000389499A CA1169419A (en) 1980-11-11 1981-11-05 Method for producing 7-aminocephem compounds
US06/318,960 US4446318A (en) 1980-11-11 1981-11-06 Method for producing 7-aminocephem compounds
HU813356A HU185977B (en) 1980-11-11 1981-11-10 Process for producing 7-amino-cepheme-compounds
ES506970A ES8206535A1 (en) 1980-11-11 1981-11-10 Improvement in the method for producing 7-aminocephem compounds.
KR1019810004330A KR870001985B1 (en) 1980-11-11 1981-11-11 Process for preparing 7-amino-cephem compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9329381A JPS57209292A (en) 1981-06-17 1981-06-17 Preparation of 7-aminocephem compound

Publications (2)

Publication Number Publication Date
JPS57209292A true JPS57209292A (en) 1982-12-22
JPH0161112B2 JPH0161112B2 (en) 1989-12-27

Family

ID=14078330

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9329381A Granted JPS57209292A (en) 1980-11-11 1981-06-17 Preparation of 7-aminocephem compound

Country Status (1)

Country Link
JP (1) JPS57209292A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0675215U (en) * 1993-04-05 1994-10-25 株式会社医研工業 Piercing hole protector

Also Published As

Publication number Publication date
JPH0161112B2 (en) 1989-12-27

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