JPS57131779A - Preparation of alpha-acetyllactone - Google Patents
Preparation of alpha-acetyllactoneInfo
- Publication number
- JPS57131779A JPS57131779A JP1747481A JP1747481A JPS57131779A JP S57131779 A JPS57131779 A JP S57131779A JP 1747481 A JP1747481 A JP 1747481A JP 1747481 A JP1747481 A JP 1747481A JP S57131779 A JPS57131779 A JP S57131779A
- Authority
- JP
- Japan
- Prior art keywords
- acetyllactone
- intramolecular alkylation
- ester derivative
- acetoacetic ester
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Epoxy Compounds (AREA)
- Pyrane Compounds (AREA)
- Furan Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as a synthetic intermediate, etc. for an ameliorant of sequelae due to the cerebral thrombosis easily in high yield, by the intramolecular alkylation of a specific acetoacetic ester derivative.
CONSTITUTION: An acetoacetic ester derivative of formulaI[X is halogen or RSO2O (R is alkyl or aryl); n is an integer 1W4]is subjected to the intramolecular alkylation to give an α-acetyllactone of formula II. The intramolecular alkylation is carried out in the presence of an alkali metal, e.g. Li, or a basic substance, e.g. NaH, in a solvent, e.g. benzene or THF. Preferably, a metallic iodide, e.g. NaI, or crown ether is used for increasing the reaction yield.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1747481A JPS57131779A (en) | 1981-02-10 | 1981-02-10 | Preparation of alpha-acetyllactone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1747481A JPS57131779A (en) | 1981-02-10 | 1981-02-10 | Preparation of alpha-acetyllactone |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57131779A true JPS57131779A (en) | 1982-08-14 |
JPH0219113B2 JPH0219113B2 (en) | 1990-04-27 |
Family
ID=11944997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1747481A Granted JPS57131779A (en) | 1981-02-10 | 1981-02-10 | Preparation of alpha-acetyllactone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57131779A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9139553B2 (en) | 2006-03-21 | 2015-09-22 | The Governors Of The University Of Alberta | Poly(ethylene oxide)-block-poly(ester) block copolymers |
-
1981
- 1981-02-10 JP JP1747481A patent/JPS57131779A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9139553B2 (en) | 2006-03-21 | 2015-09-22 | The Governors Of The University Of Alberta | Poly(ethylene oxide)-block-poly(ester) block copolymers |
Also Published As
Publication number | Publication date |
---|---|
JPH0219113B2 (en) | 1990-04-27 |
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