JPS57131779A - Preparation of alpha-acetyllactone - Google Patents

Preparation of alpha-acetyllactone

Info

Publication number
JPS57131779A
JPS57131779A JP1747481A JP1747481A JPS57131779A JP S57131779 A JPS57131779 A JP S57131779A JP 1747481 A JP1747481 A JP 1747481A JP 1747481 A JP1747481 A JP 1747481A JP S57131779 A JPS57131779 A JP S57131779A
Authority
JP
Japan
Prior art keywords
acetyllactone
intramolecular alkylation
ester derivative
acetoacetic ester
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1747481A
Other languages
Japanese (ja)
Other versions
JPH0219113B2 (en
Inventor
Hideji Takagaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DIC Corp
Original Assignee
Dainippon Ink and Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Ink and Chemicals Co Ltd filed Critical Dainippon Ink and Chemicals Co Ltd
Priority to JP1747481A priority Critical patent/JPS57131779A/en
Publication of JPS57131779A publication Critical patent/JPS57131779A/en
Publication of JPH0219113B2 publication Critical patent/JPH0219113B2/ja
Granted legal-status Critical Current

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  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a synthetic intermediate, etc. for an ameliorant of sequelae due to the cerebral thrombosis easily in high yield, by the intramolecular alkylation of a specific acetoacetic ester derivative.
CONSTITUTION: An acetoacetic ester derivative of formulaI[X is halogen or RSO2O (R is alkyl or aryl); n is an integer 1W4]is subjected to the intramolecular alkylation to give an α-acetyllactone of formula II. The intramolecular alkylation is carried out in the presence of an alkali metal, e.g. Li, or a basic substance, e.g. NaH, in a solvent, e.g. benzene or THF. Preferably, a metallic iodide, e.g. NaI, or crown ether is used for increasing the reaction yield.
COPYRIGHT: (C)1982,JPO&Japio
JP1747481A 1981-02-10 1981-02-10 Preparation of alpha-acetyllactone Granted JPS57131779A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1747481A JPS57131779A (en) 1981-02-10 1981-02-10 Preparation of alpha-acetyllactone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1747481A JPS57131779A (en) 1981-02-10 1981-02-10 Preparation of alpha-acetyllactone

Publications (2)

Publication Number Publication Date
JPS57131779A true JPS57131779A (en) 1982-08-14
JPH0219113B2 JPH0219113B2 (en) 1990-04-27

Family

ID=11944997

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1747481A Granted JPS57131779A (en) 1981-02-10 1981-02-10 Preparation of alpha-acetyllactone

Country Status (1)

Country Link
JP (1) JPS57131779A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9139553B2 (en) 2006-03-21 2015-09-22 The Governors Of The University Of Alberta Poly(ethylene oxide)-block-poly(ester) block copolymers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9139553B2 (en) 2006-03-21 2015-09-22 The Governors Of The University Of Alberta Poly(ethylene oxide)-block-poly(ester) block copolymers

Also Published As

Publication number Publication date
JPH0219113B2 (en) 1990-04-27

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