JPS5782392A - Preparation of 7-aminocephem compound - Google Patents
Preparation of 7-aminocephem compoundInfo
- Publication number
- JPS5782392A JPS5782392A JP15920880A JP15920880A JPS5782392A JP S5782392 A JPS5782392 A JP S5782392A JP 15920880 A JP15920880 A JP 15920880A JP 15920880 A JP15920880 A JP 15920880A JP S5782392 A JPS5782392 A JP S5782392A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- water
- ester
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as an intermediate for the preparation of antimicrobial agents, in high yield, by reacting 7-aminocephalosporanic acid or its ester at the 4-position with a thiol compound, water, and diphosphoryl tetrachloride, in an organic solvent.
CONSTITUTION: The compound of formula II (R2 is residue of thiol compound) or its ester at the 4-position is prepared by reacting (A) 1mol of the compound of formula I (R1 is H or methoxy; R is carboxylic acid acyl) or its ester at the 4-position, with (B) about 1mol, in some cases, about 1.5mol of a thiol compound, (C) 1W20mol, pref. 2W8mol of water (sum of the water contained in the compound of formula I and added water), and (D) 2W8mol of diphosphoryl tetrachloride, in an organic solvent such as acetonitrile. The compound of formula I used as a starting raw material can be obtained easily from cephalosporin C (CPC), etc.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15920880A JPS5782392A (en) | 1980-11-11 | 1980-11-11 | Preparation of 7-aminocephem compound |
EP81109233A EP0051824B1 (en) | 1980-11-11 | 1981-10-29 | Improvement in the method for producing 7-aminocephem compounds |
AT81109233T ATE17489T1 (en) | 1980-11-11 | 1981-10-29 | PROCESSES FOR THE PREPARATION OF 7-AMINOCEPHEM COMPOUNDS. |
DE8181109233T DE3173529D1 (en) | 1980-11-11 | 1981-10-29 | Improvement in the method for producing 7-aminocephem compounds |
CA000389499A CA1169419A (en) | 1980-11-11 | 1981-11-05 | Method for producing 7-aminocephem compounds |
US06/318,960 US4446318A (en) | 1980-11-11 | 1981-11-06 | Method for producing 7-aminocephem compounds |
HU813356A HU185977B (en) | 1980-11-11 | 1981-11-10 | Process for producing 7-amino-cepheme-compounds |
ES506970A ES506970A0 (en) | 1980-11-11 | 1981-11-10 | AN IMPROVED METHOD FOR PRODUCING A 7-AMINOCE-FEM COMPOUND. |
KR1019810004330A KR870001985B1 (en) | 1980-11-11 | 1981-11-11 | Process for preparing 7-amino-cephem compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15920880A JPS5782392A (en) | 1980-11-11 | 1980-11-11 | Preparation of 7-aminocephem compound |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5782392A true JPS5782392A (en) | 1982-05-22 |
Family
ID=15688677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15920880A Pending JPS5782392A (en) | 1980-11-11 | 1980-11-11 | Preparation of 7-aminocephem compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5782392A (en) |
-
1980
- 1980-11-11 JP JP15920880A patent/JPS5782392A/en active Pending
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