JPS5782392A - Preparation of 7-aminocephem compound - Google Patents

Preparation of 7-aminocephem compound

Info

Publication number
JPS5782392A
JPS5782392A JP15920880A JP15920880A JPS5782392A JP S5782392 A JPS5782392 A JP S5782392A JP 15920880 A JP15920880 A JP 15920880A JP 15920880 A JP15920880 A JP 15920880A JP S5782392 A JPS5782392 A JP S5782392A
Authority
JP
Japan
Prior art keywords
compound
formula
water
ester
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15920880A
Other languages
Japanese (ja)
Inventor
Kenzo Naito
Haruo Shinpo
Kazuo Tsukamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP15920880A priority Critical patent/JPS5782392A/en
Priority to EP81109233A priority patent/EP0051824B1/en
Priority to AT81109233T priority patent/ATE17489T1/en
Priority to DE8181109233T priority patent/DE3173529D1/en
Priority to CA000389499A priority patent/CA1169419A/en
Priority to US06/318,960 priority patent/US4446318A/en
Priority to HU813356A priority patent/HU185977B/en
Priority to ES506970A priority patent/ES506970A0/en
Priority to KR1019810004330A priority patent/KR870001985B1/en
Publication of JPS5782392A publication Critical patent/JPS5782392A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To prepare the titled compound useful as an intermediate for the preparation of antimicrobial agents, in high yield, by reacting 7-aminocephalosporanic acid or its ester at the 4-position with a thiol compound, water, and diphosphoryl tetrachloride, in an organic solvent.
CONSTITUTION: The compound of formula II (R2 is residue of thiol compound) or its ester at the 4-position is prepared by reacting (A) 1mol of the compound of formula I (R1 is H or methoxy; R is carboxylic acid acyl) or its ester at the 4-position, with (B) about 1mol, in some cases, about 1.5mol of a thiol compound, (C) 1W20mol, pref. 2W8mol of water (sum of the water contained in the compound of formula I and added water), and (D) 2W8mol of diphosphoryl tetrachloride, in an organic solvent such as acetonitrile. The compound of formula I used as a starting raw material can be obtained easily from cephalosporin C (CPC), etc.
COPYRIGHT: (C)1982,JPO&Japio
JP15920880A 1980-11-11 1980-11-11 Preparation of 7-aminocephem compound Pending JPS5782392A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP15920880A JPS5782392A (en) 1980-11-11 1980-11-11 Preparation of 7-aminocephem compound
EP81109233A EP0051824B1 (en) 1980-11-11 1981-10-29 Improvement in the method for producing 7-aminocephem compounds
AT81109233T ATE17489T1 (en) 1980-11-11 1981-10-29 PROCESSES FOR THE PREPARATION OF 7-AMINOCEPHEM COMPOUNDS.
DE8181109233T DE3173529D1 (en) 1980-11-11 1981-10-29 Improvement in the method for producing 7-aminocephem compounds
CA000389499A CA1169419A (en) 1980-11-11 1981-11-05 Method for producing 7-aminocephem compounds
US06/318,960 US4446318A (en) 1980-11-11 1981-11-06 Method for producing 7-aminocephem compounds
HU813356A HU185977B (en) 1980-11-11 1981-11-10 Process for producing 7-amino-cepheme-compounds
ES506970A ES506970A0 (en) 1980-11-11 1981-11-10 AN IMPROVED METHOD FOR PRODUCING A 7-AMINOCE-FEM COMPOUND.
KR1019810004330A KR870001985B1 (en) 1980-11-11 1981-11-11 Process for preparing 7-amino-cephem compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15920880A JPS5782392A (en) 1980-11-11 1980-11-11 Preparation of 7-aminocephem compound

Publications (1)

Publication Number Publication Date
JPS5782392A true JPS5782392A (en) 1982-05-22

Family

ID=15688677

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15920880A Pending JPS5782392A (en) 1980-11-11 1980-11-11 Preparation of 7-aminocephem compound

Country Status (1)

Country Link
JP (1) JPS5782392A (en)

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