JPS6442475A - Thiazolidine derivative - Google Patents

Thiazolidine derivative

Info

Publication number
JPS6442475A
JPS6442475A JP19838087A JP19838087A JPS6442475A JP S6442475 A JPS6442475 A JP S6442475A JP 19838087 A JP19838087 A JP 19838087A JP 19838087 A JP19838087 A JP 19838087A JP S6442475 A JPS6442475 A JP S6442475A
Authority
JP
Japan
Prior art keywords
formula
expressed
thiazolidine
amnesia
remedy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP19838087A
Other languages
Japanese (ja)
Other versions
JPH0670023B2 (en
Inventor
Atsushi Furukawa
Tadashi Yoshimoto
Yukiyoshi Ajisawa
Seiichi Ikeguchi
Yukihiko Kinoshita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Priority to JP19838087A priority Critical patent/JPH0670023B2/en
Priority to US07/227,864 priority patent/US4857524A/en
Priority to EP88307334A priority patent/EP0303434A1/en
Publication of JPS6442475A publication Critical patent/JPS6442475A/en
Publication of JPH0670023B2 publication Critical patent/JPH0670023B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

NEW MATERIAL:A thiazolidine derivative expressed by formula I (formula II is 5-6 membered ring saturated hetero ring which may contain hetero atom other than N; R is H or alkoxycarbonyl). EXAMPLE:3-[(R)-(-)-3-Carbobenzoxythiazolidine-4-carbonyl]thiazolidine. USE:Useful as a remedy for amnesia. The compound expressed by formula I exhibits prolylendoheptitase inhibiting activity and is used in remedy for amnesia, senile dementia, etc., and having low toxicity and large safeness. PREPARATION:A carboxylic acid expressed by formula III or reactive functional derivative thereof is reacted with a cyclic amine expressed by formula IV in the presence of a condensing agent such as N,N'-dicyclohexylcarbodiimide to provide the compound expressed by formula I.
JP19838087A 1987-08-08 1987-08-08 Thiazolidine derivative Expired - Lifetime JPH0670023B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP19838087A JPH0670023B2 (en) 1987-08-08 1987-08-08 Thiazolidine derivative
US07/227,864 US4857524A (en) 1987-08-08 1988-08-03 Thiazolidine compounds and therapeutic method
EP88307334A EP0303434A1 (en) 1987-08-08 1988-08-08 Thiazolidine compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19838087A JPH0670023B2 (en) 1987-08-08 1987-08-08 Thiazolidine derivative

Publications (2)

Publication Number Publication Date
JPS6442475A true JPS6442475A (en) 1989-02-14
JPH0670023B2 JPH0670023B2 (en) 1994-09-07

Family

ID=16390158

Family Applications (1)

Application Number Title Priority Date Filing Date
JP19838087A Expired - Lifetime JPH0670023B2 (en) 1987-08-08 1987-08-08 Thiazolidine derivative

Country Status (1)

Country Link
JP (1) JPH0670023B2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006919A1 (en) * 1988-12-14 1990-06-28 Kabushiki Kaisha Yakult Honsha New thioproline derivative
WO1991018877A1 (en) * 1990-06-07 1991-12-12 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
WO1993013065A1 (en) * 1991-12-27 1993-07-08 Japan Tobacco Inc. Proline derivative
WO1994012474A1 (en) 1992-11-20 1994-06-09 Japan Tobacco Inc. Compound with prolyl endopeptidase inhibitor activity and pharmaceutical use thereof
WO1995019356A1 (en) * 1994-01-18 1995-07-20 Santen Pharmaceutical Co., Ltd. Endopeptidase 24.15 inhibitor
JP2008281439A (en) * 2007-05-10 2008-11-20 Nippon Eng Kk Carrier for semiconductor device

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006919A1 (en) * 1988-12-14 1990-06-28 Kabushiki Kaisha Yakult Honsha New thioproline derivative
WO1991018877A1 (en) * 1990-06-07 1991-12-12 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
EP0536399A1 (en) * 1990-06-07 1993-04-14 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
US5407950A (en) * 1990-06-07 1995-04-18 Zeria Pharmaceutical Co., Ltd. Arylalkanoylamine derivative and drug containing the same
EP0536399B1 (en) * 1990-06-07 1996-01-24 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
WO1993013065A1 (en) * 1991-12-27 1993-07-08 Japan Tobacco Inc. Proline derivative
WO1994012474A1 (en) 1992-11-20 1994-06-09 Japan Tobacco Inc. Compound with prolyl endopeptidase inhibitor activity and pharmaceutical use thereof
WO1995019356A1 (en) * 1994-01-18 1995-07-20 Santen Pharmaceutical Co., Ltd. Endopeptidase 24.15 inhibitor
JP2008281439A (en) * 2007-05-10 2008-11-20 Nippon Eng Kk Carrier for semiconductor device

Also Published As

Publication number Publication date
JPH0670023B2 (en) 1994-09-07

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