JPS54130552A - 2-azetidinone derivative and its preparation - Google Patents
2-azetidinone derivative and its preparationInfo
- Publication number
- JPS54130552A JPS54130552A JP2001078A JP2001078A JPS54130552A JP S54130552 A JPS54130552 A JP S54130552A JP 2001078 A JP2001078 A JP 2001078A JP 2001078 A JP2001078 A JP 2001078A JP S54130552 A JPS54130552 A JP S54130552A
- Authority
- JP
- Japan
- Prior art keywords
- aralkyl
- alkyl
- aryl
- compound
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:The compound of formula I (R1 is H, OH, alkoxy, aralkyloxy, amino, etc.; R2 is alkyl, aralkyl; R3 is alkyl, aryl, aralkyl, heterocyclic group, etc.; R4 is alkyl, alkenyl, aryl, aralkyl).
EXAMPLE: (4S)-t-Butyl-α-(4-benzyloxycarbonyl-2-oxoazetidin-1-yl)-α-(acetyl)aceta mide.
USE: Antibacterial agent having β-lactamase inhibiting activity, and expected to be useful as a remedy of infections diseases. Also important as an intermediate of bicyclic β-lactam antibiotic.
PROCESS: The compound I is prepared by the condensation reaction of an aspartic acid derivative II with an aldehyde III and an isonitrile IV in a proper solvent.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001078A JPS54130552A (en) | 1978-02-23 | 1978-02-23 | 2-azetidinone derivative and its preparation |
FR7827889A FR2404632A1 (en) | 1977-09-30 | 1978-09-29 | NEW AZETIDINONE DERIVATIVES AND THEIR MANUFACTURING PROCEDURES |
CA000312398A CA1145347A (en) | 1977-09-30 | 1978-09-29 | 2-azetidinone derivatives |
GB7838626A GB2006195B (en) | 1977-09-30 | 1978-09-29 | 2-azetidinone derivatives |
DE19782842466 DE2842466A1 (en) | 1977-09-30 | 1978-09-29 | 2-AZETIDINONE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
US06/142,542 US4322345A (en) | 1977-09-30 | 1980-04-21 | 2-Azetidinone 4-carboxy derivatives and a process for producing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001078A JPS54130552A (en) | 1978-02-23 | 1978-02-23 | 2-azetidinone derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54130552A true JPS54130552A (en) | 1979-10-09 |
Family
ID=12015136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001078A Pending JPS54130552A (en) | 1977-09-30 | 1978-02-23 | 2-azetidinone derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54130552A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2572727A1 (en) * | 1984-11-02 | 1986-05-09 | Roussel Uclaf | NOVEL PROCESS FOR PREPARING OPTICALLY ACTIVE 2-AZETIDINONES, INTERMEDIATE PRODUCTS THEREOF AND FINAL PRODUCTS OBTAINED BY THE PROCESS |
-
1978
- 1978-02-23 JP JP2001078A patent/JPS54130552A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2572727A1 (en) * | 1984-11-02 | 1986-05-09 | Roussel Uclaf | NOVEL PROCESS FOR PREPARING OPTICALLY ACTIVE 2-AZETIDINONES, INTERMEDIATE PRODUCTS THEREOF AND FINAL PRODUCTS OBTAINED BY THE PROCESS |
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