SE8207475L - NEW HETEROCYCLIC ETHIC ACID DERIVATIVES AND A PROCEDURE FOR PREPARING THEREOF - Google Patents

NEW HETEROCYCLIC ETHIC ACID DERIVATIVES AND A PROCEDURE FOR PREPARING THEREOF

Info

Publication number
SE8207475L
SE8207475L SE8207475A SE8207475A SE8207475L SE 8207475 L SE8207475 L SE 8207475L SE 8207475 A SE8207475 A SE 8207475A SE 8207475 A SE8207475 A SE 8207475A SE 8207475 L SE8207475 L SE 8207475L
Authority
SE
Sweden
Prior art keywords
image
general formula
preparing
procedure
acid derivatives
Prior art date
Application number
SE8207475A
Other languages
Swedish (sv)
Other versions
SE8207475D0 (en
SE453083B (en
Inventor
K Lempert
G Doleschall
J Fetter
G Hornyak
P Huszthy
J Nyitrai
G Simig
K Zauer
T Gizur
K Harsanyi
G Fekete
L Szporny
G Hajos
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE8207475D0 publication Critical patent/SE8207475D0/en
Publication of SE8207475L publication Critical patent/SE8207475L/en
Publication of SE453083B publication Critical patent/SE453083B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

New heterocyclic acetic acid compounds of the general formula (I), <IMAGE> wherein Y<1> and Y<2> form together a removable carbonyl protecting group, and R is a removable amido protecting group, are prepared in the way that a compound of the general formula (II), <IMAGE> wherein R, Y<1> and Y<2> are as defined above, is activated on the carboxy group and then reacted with diazomethane, and the resulting new compound of the general formula (II), <IMAGE> wherein R, Y<1> and Y<2> are as defined above, is subjected to diazoketone rearrangement in the presence of water. The new compounds according to the invention can be incorporated into pharmaceutical preparations and are valuable intermediates in the synthesis of thienamycin and thienamycin analogues.
SE8207475A 1981-12-30 1982-12-29 PROCEDURE FOR PREPARING AZETIDINONETIC ACID DERIVATIVES SE453083B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU814012A HU184495B (en) 1981-12-30 1981-12-30 Process for preparing new azetidinone-acetic acids

Publications (3)

Publication Number Publication Date
SE8207475D0 SE8207475D0 (en) 1982-12-29
SE8207475L true SE8207475L (en) 1983-07-01
SE453083B SE453083B (en) 1988-01-11

Family

ID=10966505

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8207475A SE453083B (en) 1981-12-30 1982-12-29 PROCEDURE FOR PREPARING AZETIDINONETIC ACID DERIVATIVES

Country Status (19)

Country Link
JP (1) JPS58118566A (en)
AT (1) AT379147B (en)
AU (1) AU554739B2 (en)
BE (1) BE895489A (en)
CA (1) CA1189865A (en)
CH (1) CH655926A5 (en)
DE (1) DE3248672A1 (en)
ES (1) ES8405761A1 (en)
FI (1) FI824516L (en)
FR (1) FR2518998B1 (en)
GB (1) GB2112393B (en)
GR (1) GR78428B (en)
HU (1) HU184495B (en)
IT (1) IT1210968B (en)
LU (1) LU84568A1 (en)
NL (1) NL8205064A (en)
PL (1) PL137593B1 (en)
SE (1) SE453083B (en)
ZA (1) ZA829593B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190404B (en) * 1982-07-30 1986-09-29 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing amino-lactone-carboxylic acid
HU187424B (en) * 1982-11-05 1986-01-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing new azetidinyl-acetic acids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT71553B (en) * 1979-07-23 1981-12-14 Merck & Co Inc Process for the preparation of thienamycin and intermediates
JPS57167964A (en) * 1981-04-09 1982-10-16 Toyama Chem Co Ltd Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative
JPS57176982A (en) * 1981-04-24 1982-10-30 Shionogi & Co Ltd Dioxolanylazetidinone compound, its preparation and use

Also Published As

Publication number Publication date
FI824516L (en) 1983-07-01
IT8225060A0 (en) 1982-12-30
NL8205064A (en) 1983-07-18
SE8207475D0 (en) 1982-12-29
CH655926A5 (en) 1986-05-30
AU554739B2 (en) 1986-09-04
IT1210968B (en) 1989-09-29
ES518720A0 (en) 1984-06-16
HU184495B (en) 1984-08-28
SE453083B (en) 1988-01-11
BE895489A (en) 1983-06-28
GR78428B (en) 1984-09-27
FR2518998B1 (en) 1986-02-28
FR2518998A1 (en) 1983-07-01
PL137593B1 (en) 1986-06-30
LU84568A1 (en) 1984-10-22
AT379147B (en) 1985-11-25
ATA450782A (en) 1985-04-15
AU9196882A (en) 1983-07-07
FI824516A0 (en) 1982-12-30
GB2112393B (en) 1985-08-14
ES8405761A1 (en) 1984-06-16
JPS58118566A (en) 1983-07-14
CA1189865A (en) 1985-07-02
GB2112393A (en) 1983-07-20
ZA829593B (en) 1983-10-26
PL239885A1 (en) 1984-01-02
DE3248672A1 (en) 1983-07-07

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