SE8207477L - PROCEDURE FOR PREPARING HETEROCYCLIC ETHIC ACID DERIVATIVES - Google Patents

PROCEDURE FOR PREPARING HETEROCYCLIC ETHIC ACID DERIVATIVES

Info

Publication number
SE8207477L
SE8207477L SE8207477A SE8207477A SE8207477L SE 8207477 L SE8207477 L SE 8207477L SE 8207477 A SE8207477 A SE 8207477A SE 8207477 A SE8207477 A SE 8207477A SE 8207477 L SE8207477 L SE 8207477L
Authority
SE
Sweden
Prior art keywords
general formula
acid derivatives
procedure
image
protecting group
Prior art date
Application number
SE8207477A
Other languages
Swedish (sv)
Other versions
SE453085B (en
SE8207477D0 (en
Inventor
K Lempert
G Doleschall
J Fetter
G Hornyak
J Nyitrai
G Simig
K Zauer
T Gizur
K Harsanyi
G Fekete
L Szporny
G Hajos
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE8207477D0 publication Critical patent/SE8207477D0/en
Publication of SE8207477L publication Critical patent/SE8207477L/en
Publication of SE453085B publication Critical patent/SE453085B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Heterocyclic acetic acid derivatives of the general formula (I), <IMAGE> wherein Y<1> and Y<2> form together a removable carbonyl protecting group, and X is a selectively removable esterifying group, are prepared by esterifying a compound of the general formula (III), <IMAGE> wherein Y<1> and Y<2> are as defined above and R' is a removable amido protecting group other than phenyl group, and removing the protecting group R' of the resulting novel compound of the general formula (II), <IMAGE> wherein X, R', Y<1> and Y<2> are as defined above. The compounds of the general formula (I) are valuable intermediates of the synthesis of thienamycin and thienamycin analogues.
SE8207477A 1981-12-30 1982-12-29 PROCEDURE FOR THE PREPARATION OF AZETIDINON ETHIC ACID DERIVATIVE SE453085B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU814014A HU185081B (en) 1981-12-30 1981-12-30 Process for preparing azetidinone-acetic acid derivatives

Publications (3)

Publication Number Publication Date
SE8207477D0 SE8207477D0 (en) 1982-12-29
SE8207477L true SE8207477L (en) 1983-07-01
SE453085B SE453085B (en) 1988-01-11

Family

ID=10966515

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8207477A SE453085B (en) 1981-12-30 1982-12-29 PROCEDURE FOR THE PREPARATION OF AZETIDINON ETHIC ACID DERIVATIVE

Country Status (19)

Country Link
JP (1) JPS58118563A (en)
AT (1) AT379148B (en)
AU (1) AU557596B2 (en)
BE (1) BE895490A (en)
CA (1) CA1199644A (en)
CH (1) CH660186A5 (en)
DE (1) DE3248675A1 (en)
ES (1) ES518722A0 (en)
FI (1) FI824517L (en)
FR (1) FR2518995B1 (en)
GB (1) GB2113215B (en)
GR (1) GR78429B (en)
HU (1) HU185081B (en)
IT (1) IT1191159B (en)
LU (1) LU84567A1 (en)
NL (1) NL8205070A (en)
PL (1) PL137737B1 (en)
SE (1) SE453085B (en)
ZA (1) ZA829595B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187424B (en) * 1982-11-05 1986-01-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing new azetidinyl-acetic acids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE15039T1 (en) * 1979-04-27 1985-09-15 Merck & Co Inc PROCESS FOR THE PREPARATION OF 3-(1-HYDROXYAETHYL)-AZETIDINONES.
PT71553B (en) * 1979-07-23 1981-12-14 Merck & Co Inc Process for the preparation of thienamycin and intermediates
US4287123A (en) * 1980-01-14 1981-09-01 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
JPS57176982A (en) * 1981-04-24 1982-10-30 Shionogi & Co Ltd Dioxolanylazetidinone compound, its preparation and use

Also Published As

Publication number Publication date
SE453085B (en) 1988-01-11
FR2518995B1 (en) 1986-04-18
GB2113215B (en) 1985-10-02
ES8405763A1 (en) 1984-06-16
IT8225062A1 (en) 1984-06-30
GB2113215A (en) 1983-08-03
FI824517L (en) 1983-07-01
ATA453382A (en) 1985-04-15
FR2518995A1 (en) 1983-07-01
FI824517A0 (en) 1982-12-30
PL239882A1 (en) 1984-01-02
SE8207477D0 (en) 1982-12-29
CA1199644A (en) 1986-01-21
ES518722A0 (en) 1984-06-16
PL137737B1 (en) 1986-07-31
IT1191159B (en) 1988-02-24
LU84567A1 (en) 1984-10-22
BE895490A (en) 1983-06-28
JPS58118563A (en) 1983-07-14
AU557596B2 (en) 1986-12-24
AT379148B (en) 1985-11-25
DE3248675A1 (en) 1983-07-07
GR78429B (en) 1984-09-27
NL8205070A (en) 1983-07-18
ZA829595B (en) 1983-10-26
AU9197082A (en) 1983-07-07
CH660186A5 (en) 1987-03-31
IT8225062A0 (en) 1982-12-30
HU185081B (en) 1984-11-28

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