JPS54138536A - O-(n-substituted aminomethyl)phenylaceticacid and its preparation - Google Patents

O-(n-substituted aminomethyl)phenylaceticacid and its preparation

Info

Publication number
JPS54138536A
JPS54138536A JP4542978A JP4542978A JPS54138536A JP S54138536 A JPS54138536 A JP S54138536A JP 4542978 A JP4542978 A JP 4542978A JP 4542978 A JP4542978 A JP 4542978A JP S54138536 A JPS54138536 A JP S54138536A
Authority
JP
Japan
Prior art keywords
formula
substituted aminomethyl
phenylaceticacid
preparation
phenylacetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4542978A
Other languages
Japanese (ja)
Inventor
Ikuo Matsumoto
Junji Yoshizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP4542978A priority Critical patent/JPS54138536A/en
Publication of JPS54138536A publication Critical patent/JPS54138536A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:An o-(N-substituted aminomethyl)phenylacetic acid of formula I: (R is alkyl or aralkyl group; R1 is H or alkyl group; R may form a heterocycle with R1 and the adjacent N atom except where R is methyl group and R1 is H).
EXAMPLE: o-(N-Methylaminomethyl)phenyl-acetic acid.
USE: Intermediates for the synthesis of β-lactam antibiotics.
PROCESS: A novel o-(halomethyl)phenylacetic acid of formula II: (X is Cl or Br) is reacted with an amine of the formula RR1NH to give the objective compound of formula I. The compound of formula II can be obtained by ring opening of 3- isochromanone with a hydrogen halide.
COPYRIGHT: (C)1979,JPO&Japio
JP4542978A 1978-04-19 1978-04-19 O-(n-substituted aminomethyl)phenylaceticacid and its preparation Pending JPS54138536A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4542978A JPS54138536A (en) 1978-04-19 1978-04-19 O-(n-substituted aminomethyl)phenylaceticacid and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4542978A JPS54138536A (en) 1978-04-19 1978-04-19 O-(n-substituted aminomethyl)phenylaceticacid and its preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP61200025A Division JPS6242959A (en) 1986-08-28 1986-08-28 Production of 0-(n-substituted aminomethyl)phenylacetic acid

Publications (1)

Publication Number Publication Date
JPS54138536A true JPS54138536A (en) 1979-10-27

Family

ID=12719041

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4542978A Pending JPS54138536A (en) 1978-04-19 1978-04-19 O-(n-substituted aminomethyl)phenylaceticacid and its preparation

Country Status (1)

Country Link
JP (1) JPS54138536A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000850A1 (en) * 1995-06-20 1997-01-09 Sagami Chemical Research Center Process for producing 2-(halomethyl)phenylacetic acid esters

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082912A (en) * 1976-06-30 1978-04-04 Bristol-Myers Company Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylmethyl)-3-cephem-4-carboxylic acids their salts and easily hydrolyzed esters

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082912A (en) * 1976-06-30 1978-04-04 Bristol-Myers Company Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylmethyl)-3-cephem-4-carboxylic acids their salts and easily hydrolyzed esters

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000850A1 (en) * 1995-06-20 1997-01-09 Sagami Chemical Research Center Process for producing 2-(halomethyl)phenylacetic acid esters
US5886211A (en) * 1995-06-20 1999-03-23 Sagami Chemical Research Center Process for producing 2-(halomethyl)phenylacetic acid esters
KR100415000B1 (en) * 1995-06-20 2004-05-27 자이단호오징 사가미 츄오 카가쿠겡큐쇼 Preparation of 3-isochromanone

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