JPS54138536A - O-(n-substituted aminomethyl)phenylaceticacid and its preparation - Google Patents
O-(n-substituted aminomethyl)phenylaceticacid and its preparationInfo
- Publication number
- JPS54138536A JPS54138536A JP4542978A JP4542978A JPS54138536A JP S54138536 A JPS54138536 A JP S54138536A JP 4542978 A JP4542978 A JP 4542978A JP 4542978 A JP4542978 A JP 4542978A JP S54138536 A JPS54138536 A JP S54138536A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- substituted aminomethyl
- phenylaceticacid
- preparation
- phenylacetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:An o-(N-substituted aminomethyl)phenylacetic acid of formula I: (R is alkyl or aralkyl group; R1 is H or alkyl group; R may form a heterocycle with R1 and the adjacent N atom except where R is methyl group and R1 is H).
EXAMPLE: o-(N-Methylaminomethyl)phenyl-acetic acid.
USE: Intermediates for the synthesis of β-lactam antibiotics.
PROCESS: A novel o-(halomethyl)phenylacetic acid of formula II: (X is Cl or Br) is reacted with an amine of the formula RR1NH to give the objective compound of formula I. The compound of formula II can be obtained by ring opening of 3- isochromanone with a hydrogen halide.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4542978A JPS54138536A (en) | 1978-04-19 | 1978-04-19 | O-(n-substituted aminomethyl)phenylaceticacid and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4542978A JPS54138536A (en) | 1978-04-19 | 1978-04-19 | O-(n-substituted aminomethyl)phenylaceticacid and its preparation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP61200025A Division JPS6242959A (en) | 1986-08-28 | 1986-08-28 | Production of 0-(n-substituted aminomethyl)phenylacetic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54138536A true JPS54138536A (en) | 1979-10-27 |
Family
ID=12719041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4542978A Pending JPS54138536A (en) | 1978-04-19 | 1978-04-19 | O-(n-substituted aminomethyl)phenylaceticacid and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54138536A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997000850A1 (en) * | 1995-06-20 | 1997-01-09 | Sagami Chemical Research Center | Process for producing 2-(halomethyl)phenylacetic acid esters |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4082912A (en) * | 1976-06-30 | 1978-04-04 | Bristol-Myers Company | Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylmethyl)-3-cephem-4-carboxylic acids their salts and easily hydrolyzed esters |
-
1978
- 1978-04-19 JP JP4542978A patent/JPS54138536A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4082912A (en) * | 1976-06-30 | 1978-04-04 | Bristol-Myers Company | Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylmethyl)-3-cephem-4-carboxylic acids their salts and easily hydrolyzed esters |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997000850A1 (en) * | 1995-06-20 | 1997-01-09 | Sagami Chemical Research Center | Process for producing 2-(halomethyl)phenylacetic acid esters |
US5886211A (en) * | 1995-06-20 | 1999-03-23 | Sagami Chemical Research Center | Process for producing 2-(halomethyl)phenylacetic acid esters |
KR100415000B1 (en) * | 1995-06-20 | 2004-05-27 | 자이단호오징 사가미 츄오 카가쿠겡큐쇼 | Preparation of 3-isochromanone |
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