JPS5515457A - Dithiocarbamic acid derivative - Google Patents
Dithiocarbamic acid derivativeInfo
- Publication number
- JPS5515457A JPS5515457A JP8915378A JP8915378A JPS5515457A JP S5515457 A JPS5515457 A JP S5515457A JP 8915378 A JP8915378 A JP 8915378A JP 8915378 A JP8915378 A JP 8915378A JP S5515457 A JPS5515457 A JP S5515457A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acid derivative
- lower alkyl
- dithiocarbamic acid
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A dithiocarbamic acid derivative of formula I (R1, R2 are lower alkyl, aralkyl; R1 and R2 may together with the adjacent N atom form a heterocylic ring; R3 is H, lower alkyl; A, B are straight or branched chain alkylene; X is methylene, S), its acid addition salt, and their stereoisomers.
EXAMPLE: 3-[3-( 2-Dimethylaminoethylthiocarbamoylthio )-2(S)-methylpropionyl]- 4(R)-thiazolidinecarboxylic acid.
USE: Drug having anti-inflammatory, anti-rheumatic, hypotensive, immuno-regulating, and carcinostatic activities.
PROCESS: The compound I is prepared by reacting a compound II with a compound III in an inert solvent, in the absence or presence of catalsyt such as tertiary amine, at a temperature between the room temperature and about 150°C.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8915378A JPS5515457A (en) | 1978-07-20 | 1978-07-20 | Dithiocarbamic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8915378A JPS5515457A (en) | 1978-07-20 | 1978-07-20 | Dithiocarbamic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5515457A true JPS5515457A (en) | 1980-02-02 |
Family
ID=13962897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8915378A Pending JPS5515457A (en) | 1978-07-20 | 1978-07-20 | Dithiocarbamic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5515457A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0049842A2 (en) * | 1980-10-06 | 1982-04-21 | Merck & Co. Inc. | Substituted enantholactam derivatives, a process for the preparation and a pharmaceutical composition useful in the treatment of hypertension comprising the same, and intermediates |
WO1998043954A1 (en) * | 1997-03-27 | 1998-10-08 | Santen Pharmaceutical Co., Ltd. | Leukotriene a4 hydrolaze inhibitors |
US6747061B2 (en) | 2000-03-21 | 2004-06-08 | Atherogenics, Inc. | N-substituted dithiocarbamates for the treatment of biological disorders |
-
1978
- 1978-07-20 JP JP8915378A patent/JPS5515457A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0049842A2 (en) * | 1980-10-06 | 1982-04-21 | Merck & Co. Inc. | Substituted enantholactam derivatives, a process for the preparation and a pharmaceutical composition useful in the treatment of hypertension comprising the same, and intermediates |
WO1998043954A1 (en) * | 1997-03-27 | 1998-10-08 | Santen Pharmaceutical Co., Ltd. | Leukotriene a4 hydrolaze inhibitors |
US6242476B1 (en) | 1997-03-27 | 2001-06-05 | Santen Pharmaceutical Co., Ltd. | Leukotriene A4 hydrolase inhibitors |
US6747061B2 (en) | 2000-03-21 | 2004-06-08 | Atherogenics, Inc. | N-substituted dithiocarbamates for the treatment of biological disorders |
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