ES8405763A1 - Azetidinones - Google Patents

Azetidinones

Info

Publication number
ES8405763A1
ES8405763A1 ES518722A ES518722A ES8405763A1 ES 8405763 A1 ES8405763 A1 ES 8405763A1 ES 518722 A ES518722 A ES 518722A ES 518722 A ES518722 A ES 518722A ES 8405763 A1 ES8405763 A1 ES 8405763A1
Authority
ES
Spain
Prior art keywords
general formula
image
protecting group
removable
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518722A
Other languages
Spanish (es)
Other versions
ES518722A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES518722A0 publication Critical patent/ES518722A0/en
Publication of ES8405763A1 publication Critical patent/ES8405763A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Heterocyclic acetic acid derivatives of the general formula (I), < IMAGE > wherein Y<1> and Y<2> form together a removable carbonyl protecting group, and X is a selectively removable esterifying group, are prepared by esterifying a compound of the general formula (III), < IMAGE > wherein Y<1> and Y<2> are as defined above and R' is a removable amido protecting group other than phenyl group, and removing the protecting group R' of the resulting novel compound of the general formula (II), < IMAGE > wherein X, R', Y<1> and Y<2> are as defined above. The compounds of the general formula (I) are valuable intermediates of the synthesis of thienamycin and thienamycin analogues.
ES518722A 1981-12-30 1982-12-30 Azetidinones Expired ES8405763A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU814014A HU185081B (en) 1981-12-30 1981-12-30 Process for preparing azetidinone-acetic acid derivatives

Publications (2)

Publication Number Publication Date
ES518722A0 ES518722A0 (en) 1984-06-16
ES8405763A1 true ES8405763A1 (en) 1984-06-16

Family

ID=10966515

Family Applications (1)

Application Number Title Priority Date Filing Date
ES518722A Expired ES8405763A1 (en) 1981-12-30 1982-12-30 Azetidinones

Country Status (19)

Country Link
JP (1) JPS58118563A (en)
AT (1) AT379148B (en)
AU (1) AU557596B2 (en)
BE (1) BE895490A (en)
CA (1) CA1199644A (en)
CH (1) CH660186A5 (en)
DE (1) DE3248675A1 (en)
ES (1) ES8405763A1 (en)
FI (1) FI824517L (en)
FR (1) FR2518995B1 (en)
GB (1) GB2113215B (en)
GR (1) GR78429B (en)
HU (1) HU185081B (en)
IT (1) IT1191159B (en)
LU (1) LU84567A1 (en)
NL (1) NL8205070A (en)
PL (1) PL137737B1 (en)
SE (1) SE453085B (en)
ZA (1) ZA829595B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187424B (en) * 1982-11-05 1986-01-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing new azetidinyl-acetic acids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0018594B1 (en) * 1979-04-27 1985-08-21 Merck & Co. Inc. Process for the preparation of 3-(1-hydroxyethyl)-azetidinones
PT71553B (en) * 1979-07-23 1981-12-14 Merck & Co Inc Process for the preparation of thienamycin and intermediates
US4287123A (en) * 1980-01-14 1981-09-01 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
JPS57176982A (en) * 1981-04-24 1982-10-30 Shionogi & Co Ltd Dioxolanylazetidinone compound, its preparation and use

Also Published As

Publication number Publication date
PL137737B1 (en) 1986-07-31
ATA453382A (en) 1985-04-15
IT1191159B (en) 1988-02-24
IT8225062A1 (en) 1984-06-30
AT379148B (en) 1985-11-25
SE8207477D0 (en) 1982-12-29
SE8207477L (en) 1983-07-01
LU84567A1 (en) 1984-10-22
GB2113215A (en) 1983-08-03
GR78429B (en) 1984-09-27
FI824517L (en) 1983-07-01
ES518722A0 (en) 1984-06-16
FR2518995B1 (en) 1986-04-18
AU557596B2 (en) 1986-12-24
AU9197082A (en) 1983-07-07
ZA829595B (en) 1983-10-26
HU185081B (en) 1984-11-28
SE453085B (en) 1988-01-11
GB2113215B (en) 1985-10-02
FR2518995A1 (en) 1983-07-01
BE895490A (en) 1983-06-28
DE3248675A1 (en) 1983-07-07
PL239882A1 (en) 1984-01-02
NL8205070A (en) 1983-07-18
CH660186A5 (en) 1987-03-31
FI824517A0 (en) 1982-12-30
IT8225062A0 (en) 1982-12-30
CA1199644A (en) 1986-01-21
JPS58118563A (en) 1983-07-14

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