ES8405762A1 - Azetidinones - Google Patents
AzetidinonesInfo
- Publication number
- ES8405762A1 ES8405762A1 ES518721A ES518721A ES8405762A1 ES 8405762 A1 ES8405762 A1 ES 8405762A1 ES 518721 A ES518721 A ES 518721A ES 518721 A ES518721 A ES 518721A ES 8405762 A1 ES8405762 A1 ES 8405762A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- image
- defined above
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- WKDDRNSBRWANNC-ATRFCDNQSA-N Thienamycin Chemical compound C1C(SCCN)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 WKDDRNSBRWANNC-ATRFCDNQSA-N 0.000 abstract 2
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- -1 aminophenyl protecting group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000006243 carbonyl protecting group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
New compounds of the general formula (I), < IMAGE > wherein Y<1> and Y<2> form together a removable carbonyl protecting group and X is a selectively removable esterifying group, are prepared in the way that a compound of the general formula (IV), < IMAGE > wherein Y<1> and Y<2> are as defined above, is nitrated and then reduced, the resulting new compound of the general formula (III), wherein < IMAGE > Y<1> and Y<2> are as defined above and A stands for nitro group and then for amino group, is converted into a new ester of the general formula (II), wherein Y<1>, Y<2> and X are as defined above, in a manner known per se, < IMAGE > and the aminophenyl protecting group of the resulting compound is split off. The new compounds of the general formula (I) can be applied primarily as intermediates in the synthesis of thienamycin or thienamycin analogues.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU814013A HU184496B (en) | 1981-12-30 | 1981-12-30 | Process for producing new azetidinon-acetic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8405762A1 true ES8405762A1 (en) | 1984-06-16 |
| ES518721A0 ES518721A0 (en) | 1984-06-16 |
Family
ID=10966510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES518721A Granted ES518721A0 (en) | 1981-12-30 | 1982-12-30 | PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF TRANS-3-SUBSTITUTED-4-OXO-2-ACETIDINYL ACID. |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS58118564A (en) |
| AT (1) | AT378770B (en) |
| AU (1) | AU555597B2 (en) |
| BE (1) | BE895487A (en) |
| CA (1) | CA1189866A (en) |
| CH (1) | CH656123A5 (en) |
| DE (1) | DE3248673A1 (en) |
| ES (1) | ES518721A0 (en) |
| FI (1) | FI824519L (en) |
| FR (1) | FR2518996B1 (en) |
| GB (1) | GB2114125B (en) |
| GR (1) | GR77071B (en) |
| HU (1) | HU184496B (en) |
| IT (1) | IT1210969B (en) |
| LU (1) | LU84565A1 (en) |
| NL (1) | NL8205068A (en) |
| PL (1) | PL137594B1 (en) |
| SE (1) | SE453084B (en) |
| ZA (1) | ZA829594B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT71553B (en) * | 1979-07-23 | 1981-12-14 | Merck & Co Inc | Process for the preparation of thienamycin and intermediates |
| JPS57167964A (en) * | 1981-04-09 | 1982-10-16 | Toyama Chem Co Ltd | Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative |
| JPS57176982A (en) * | 1981-04-24 | 1982-10-30 | Shionogi & Co Ltd | Dioxolanylazetidinone compound, its preparation and use |
-
1981
- 1981-12-30 HU HU814013A patent/HU184496B/en not_active IP Right Cessation
-
1982
- 1982-12-14 AT AT0453282A patent/AT378770B/en not_active IP Right Cessation
- 1982-12-27 JP JP57234852A patent/JPS58118564A/en active Pending
- 1982-12-28 BE BE1/10674A patent/BE895487A/en not_active IP Right Cessation
- 1982-12-29 SE SE8207476A patent/SE453084B/en not_active IP Right Cessation
- 1982-12-29 LU LU84565A patent/LU84565A1/en unknown
- 1982-12-29 CH CH7606/82A patent/CH656123A5/en not_active IP Right Cessation
- 1982-12-29 FR FR8221974A patent/FR2518996B1/en not_active Expired
- 1982-12-30 ES ES518721A patent/ES518721A0/en active Granted
- 1982-12-30 PL PL1982239886A patent/PL137594B1/en unknown
- 1982-12-30 NL NL8205068A patent/NL8205068A/en not_active Application Discontinuation
- 1982-12-30 IT IT8225061A patent/IT1210969B/en active
- 1982-12-30 CA CA000418740A patent/CA1189866A/en not_active Expired
- 1982-12-30 GR GR70188A patent/GR77071B/el unknown
- 1982-12-30 AU AU91969/82A patent/AU555597B2/en not_active Ceased
- 1982-12-30 FI FI824519A patent/FI824519L/en not_active Application Discontinuation
- 1982-12-30 DE DE19823248673 patent/DE3248673A1/en not_active Withdrawn
- 1982-12-30 GB GB08236915A patent/GB2114125B/en not_active Expired
- 1982-12-30 ZA ZA829594A patent/ZA829594B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH656123A5 (en) | 1986-06-13 |
| SE453084B (en) | 1988-01-11 |
| FI824519L (en) | 1983-07-01 |
| IT8225061A0 (en) | 1982-12-30 |
| GR77071B (en) | 1984-09-05 |
| CA1189866A (en) | 1985-07-02 |
| AU555597B2 (en) | 1986-10-02 |
| BE895487A (en) | 1983-06-28 |
| GB2114125A (en) | 1983-08-17 |
| DE3248673A1 (en) | 1983-07-07 |
| SE8207476L (en) | 1983-07-01 |
| AT378770B (en) | 1985-09-25 |
| LU84565A1 (en) | 1984-10-22 |
| FR2518996A1 (en) | 1983-07-01 |
| IT1210969B (en) | 1989-09-29 |
| JPS58118564A (en) | 1983-07-14 |
| SE8207476D0 (en) | 1982-12-29 |
| NL8205068A (en) | 1983-07-18 |
| FI824519A0 (en) | 1982-12-30 |
| AU9196982A (en) | 1983-07-07 |
| HU184496B (en) | 1984-08-28 |
| PL239886A1 (en) | 1984-01-02 |
| ZA829594B (en) | 1983-10-26 |
| GB2114125B (en) | 1985-09-25 |
| FR2518996B1 (en) | 1986-02-28 |
| PL137594B1 (en) | 1986-06-30 |
| ATA453282A (en) | 1985-02-15 |
| ES518721A0 (en) | 1984-06-16 |
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