JPS5531022A - Hydroxamic acid derivative and its preparation - Google Patents

Hydroxamic acid derivative and its preparation

Info

Publication number
JPS5531022A
JPS5531022A JP10351778A JP10351778A JPS5531022A JP S5531022 A JPS5531022 A JP S5531022A JP 10351778 A JP10351778 A JP 10351778A JP 10351778 A JP10351778 A JP 10351778A JP S5531022 A JPS5531022 A JP S5531022A
Authority
JP
Japan
Prior art keywords
compound
preparation
acid derivative
alkyl
hydroxamic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10351778A
Other languages
Japanese (ja)
Inventor
Tomohiko Munakata
Takanori Oe
Atsushi Tsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP10351778A priority Critical patent/JPS5531022A/en
Priority to PCT/JP1979/000217 priority patent/WO1980000444A1/en
Priority to IT68693/79A priority patent/IT1118846B/en
Priority to ES483583A priority patent/ES483583A0/en
Priority to FR7921222A priority patent/FR2434150A1/en
Publication of JPS5531022A publication Critical patent/JPS5531022A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Abstract

NEW MATERIAL:A compound I [R1 is H, acyl, (R5)(R6)NCO-, (R5)(R6) NCS- or R7OCO-(R5 and R6 are H or alkyl; R7 is alkyl); R2 is H or lower alkyl; R3 and R4 are H, lower alkyl or phenyl; X is CH2 or S].
EXAMPLE: 3-( 3-Acetylthio-2( S )-methylpropionyl )-4( R )-thiazolidinecarbohydroxamic acid.
USE: An antihypertonic remedy. It has excellent inhibiting activity for angiotensin I transformation enzyme.
PREPARATION: A compound I (R1 is other than H) is prepared either by reacting a compound R1SCH2CH(R2)COOH with an amine II, or by reacting a compound III or its reactive derivative with a compound HN(R3)OR4. The product is hydrolyzed to give the compound I (R1 is H).
COPYRIGHT: (C)1980,JPO&Japio
JP10351778A 1978-08-24 1978-08-24 Hydroxamic acid derivative and its preparation Pending JPS5531022A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP10351778A JPS5531022A (en) 1978-08-24 1978-08-24 Hydroxamic acid derivative and its preparation
PCT/JP1979/000217 WO1980000444A1 (en) 1978-08-24 1979-08-16 Hydroxamic acid derivatives
IT68693/79A IT1118846B (en) 1978-08-24 1979-08-20 HYDROXAMIC ACID DERIVATIVES
ES483583A ES483583A0 (en) 1978-08-24 1979-08-23 METHOD OF PRODUCING HYDROXAMIC ACID DERIVATIVES
FR7921222A FR2434150A1 (en) 1978-08-24 1979-08-23 HYDROXAMIC ACID DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING IT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10351778A JPS5531022A (en) 1978-08-24 1978-08-24 Hydroxamic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5531022A true JPS5531022A (en) 1980-03-05

Family

ID=14356131

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10351778A Pending JPS5531022A (en) 1978-08-24 1978-08-24 Hydroxamic acid derivative and its preparation

Country Status (5)

Country Link
JP (1) JPS5531022A (en)
ES (1) ES483583A0 (en)
FR (1) FR2434150A1 (en)
IT (1) IT1118846B (en)
WO (1) WO1980000444A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
JPS57112381A (en) * 1980-12-29 1982-07-13 Santen Pharmaceut Co Ltd Five-membered heterocyclic compound
AU4249700A (en) * 1999-04-19 2000-11-02 Sumitomo Pharmaceuticals Company, Limited Hydroxamic acid derivative
US6713477B1 (en) 2000-04-19 2004-03-30 Sumitomo Pharmaceuticals Company, Limited Hydroxamic acid derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052511A (en) * 1976-02-13 1977-10-04 E. R. Squibb & Sons, Inc. Carboxyacylproline derivatives
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
AU518147B2 (en) * 1976-12-03 1981-09-17 E.R. Squibb & Sons, Inc. Derivatives of thiazolidine, thiazine and morpholine carboxylic acids
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
FR2404635A1 (en) * 1977-09-28 1979-04-27 Science Union & Cie NEW THIOPROPRIONYLAMIDES, THEIR OBTAINING PROCEDURES AND THEIR USE IN THERAPEUTICS
YU249778A (en) * 1978-01-06 1982-10-31 Science Union & Cie Process for obtaining new thiopropione amides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor

Also Published As

Publication number Publication date
ES8101046A1 (en) 1980-04-16
FR2434150A1 (en) 1980-03-21
WO1980000444A1 (en) 1980-03-20
ES483583A0 (en) 1980-04-16
IT7968693A0 (en) 1979-08-20
IT1118846B (en) 1986-03-03

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