JPS559060A - Thia(oxa)zolidinecarboxylic acid derivative and its prepatation - Google Patents

Thia(oxa)zolidinecarboxylic acid derivative and its prepatation

Info

Publication number
JPS559060A
JPS559060A JP8320278A JP8320278A JPS559060A JP S559060 A JPS559060 A JP S559060A JP 8320278 A JP8320278 A JP 8320278A JP 8320278 A JP8320278 A JP 8320278A JP S559060 A JPS559060 A JP S559060A
Authority
JP
Japan
Prior art keywords
lower alkyl
thia
oxa
acid derivative
prepatation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8320278A
Other languages
Japanese (ja)
Inventor
Katsuo Arimura
Osamu Murakami
Taichi Oka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP8320278A priority Critical patent/JPS559060A/en
Publication of JPS559060A publication Critical patent/JPS559060A/en
Pending legal-status Critical Current

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

NEW MATERIAL:Thia(oxa)zolidinecarboxylic acid derivative of formula I [R1 is H, acyl, RNHCO- (R is alkyl), RNHCS-, ROCO-; R2 is H, lower alkyl; R3,R4 are H, lower alkyl; one of R5 and R6 is H and the other is lower alkyl or aryl, or both of the R5 and R6 are lower alkyl; R7 is H, lower alkyl, when R7 is H, the carboxyl may form a basic salt; X is S, O].
EXAMPLE: 4,5-cis-3-( 3-Acetylthio-2-methylpropionyl )-5-phenyl-4-thiazolidinecarboxylic acid methyl ester.
USE: Antihypertensive agent effective to suppress the activity of angiotensin-I- conversion enzyme.
PROCESS: The compound I is prepared by reacting a carboxylic acid II or its reactive derivative with a compound III.
COPYRIGHT: (C)1980,JPO&Japio
JP8320278A 1978-07-07 1978-07-07 Thia(oxa)zolidinecarboxylic acid derivative and its prepatation Pending JPS559060A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8320278A JPS559060A (en) 1978-07-07 1978-07-07 Thia(oxa)zolidinecarboxylic acid derivative and its prepatation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8320278A JPS559060A (en) 1978-07-07 1978-07-07 Thia(oxa)zolidinecarboxylic acid derivative and its prepatation

Publications (1)

Publication Number Publication Date
JPS559060A true JPS559060A (en) 1980-01-22

Family

ID=13795731

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8320278A Pending JPS559060A (en) 1978-07-07 1978-07-07 Thia(oxa)zolidinecarboxylic acid derivative and its prepatation

Country Status (1)

Country Link
JP (1) JPS559060A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981002893A1 (en) * 1980-04-02 1981-10-15 Santen Pharmaceutical Co Ltd Sulfur-containing acylamino acids
JPS5718611A (en) * 1980-03-05 1982-01-30 Uni Maiami Za Angiotensin converting enzyme inhibitor
JPS6272168A (en) * 1985-08-02 1987-04-02 ゼネラル・エレクトリツク・カンパニイ N(+) type amorphous silicon thin film field effect transistor for matrix liquid crystal display unit
JPS6272167A (en) * 1985-08-02 1987-04-02 ゼネラル・エレクトリツク・カンパニイ Depositing and curing method for gate electrode material forthin film field effect transistor
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor
WO1997010225A1 (en) * 1995-09-15 1997-03-20 Smithkline Beecham Plc Pyrrolidine and thiazole derivatives with antibacterial and metallo-beta-lactamase inhibitory properties

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5718611A (en) * 1980-03-05 1982-01-30 Uni Maiami Za Angiotensin converting enzyme inhibitor
JPH0460986B2 (en) * 1980-03-05 1992-09-29 Univ Miami
WO1981002893A1 (en) * 1980-04-02 1981-10-15 Santen Pharmaceutical Co Ltd Sulfur-containing acylamino acids
JPS6272168A (en) * 1985-08-02 1987-04-02 ゼネラル・エレクトリツク・カンパニイ N(+) type amorphous silicon thin film field effect transistor for matrix liquid crystal display unit
JPS6272167A (en) * 1985-08-02 1987-04-02 ゼネラル・エレクトリツク・カンパニイ Depositing and curing method for gate electrode material forthin film field effect transistor
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor
WO1997010225A1 (en) * 1995-09-15 1997-03-20 Smithkline Beecham Plc Pyrrolidine and thiazole derivatives with antibacterial and metallo-beta-lactamase inhibitory properties
US6022885A (en) * 1995-09-15 2000-02-08 Smithkline Beecham P.L.C. Pyrrolidine and thiazole derivatives with antibacterial and . metallo-.beta-lactamase inhibitory properties

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