JPS5636472A - Production of heterocyclic compound - Google Patents
Production of heterocyclic compoundInfo
- Publication number
- JPS5636472A JPS5636472A JP8692980A JP8692980A JPS5636472A JP S5636472 A JPS5636472 A JP S5636472A JP 8692980 A JP8692980 A JP 8692980A JP 8692980 A JP8692980 A JP 8692980A JP S5636472 A JPS5636472 A JP S5636472A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- halogen
- production
- inflammatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Isoxazole derivatives of formula I (R1WR3 are H, lower alkyl, substituted phenyl, R1, R2 and carbon atoms linking to these groups incoporate to form hydrocaron ring and, further, R1 may be halogen; R4 is group protecting carboxyl by forming ester).
EXAMPLE: Ethyl 5-phenyl-3-isoxazolyloxyacetate.
USE: An intermediate anti-inflammatory.
PREPARATION: A metal salt of 3-hydroxyisoxazole of formula II (M is metal atom, preferably alkali or alkaline earth metal such as Na, K or Ca) is made to react with a haloacetic ester of formula III (X is halogen), thus giving the compound of formula I. The hydrolysis of the product forms the compound of formula IV, which has anti-inflammatory activity.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8692980A JPS5636472A (en) | 1980-06-26 | 1980-06-26 | Production of heterocyclic compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8692980A JPS5636472A (en) | 1980-06-26 | 1980-06-26 | Production of heterocyclic compound |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9746773A Division JPS5747671B2 (en) | 1973-08-30 | 1973-08-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5636472A true JPS5636472A (en) | 1981-04-09 |
JPS5748156B2 JPS5748156B2 (en) | 1982-10-14 |
Family
ID=13900546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8692980A Granted JPS5636472A (en) | 1980-06-26 | 1980-06-26 | Production of heterocyclic compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5636472A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS609744U (en) * | 1983-06-30 | 1985-01-23 | トヨタ自動車株式会社 | Vehicle steering device |
-
1980
- 1980-06-26 JP JP8692980A patent/JPS5636472A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS5748156B2 (en) | 1982-10-14 |
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