JPS5636472A - Production of heterocyclic compound - Google Patents

Production of heterocyclic compound

Info

Publication number
JPS5636472A
JPS5636472A JP8692980A JP8692980A JPS5636472A JP S5636472 A JPS5636472 A JP S5636472A JP 8692980 A JP8692980 A JP 8692980A JP 8692980 A JP8692980 A JP 8692980A JP S5636472 A JPS5636472 A JP S5636472A
Authority
JP
Japan
Prior art keywords
formula
compound
halogen
production
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8692980A
Other languages
Japanese (ja)
Other versions
JPS5748156B2 (en
Inventor
Mitsuo Nagano
Kazuo Tomita
Hiroshi Takagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP8692980A priority Critical patent/JPS5636472A/en
Publication of JPS5636472A publication Critical patent/JPS5636472A/en
Publication of JPS5748156B2 publication Critical patent/JPS5748156B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Isoxazole derivatives of formula I (R1WR3 are H, lower alkyl, substituted phenyl, R1, R2 and carbon atoms linking to these groups incoporate to form hydrocaron ring and, further, R1 may be halogen; R4 is group protecting carboxyl by forming ester).
EXAMPLE: Ethyl 5-phenyl-3-isoxazolyloxyacetate.
USE: An intermediate anti-inflammatory.
PREPARATION: A metal salt of 3-hydroxyisoxazole of formula II (M is metal atom, preferably alkali or alkaline earth metal such as Na, K or Ca) is made to react with a haloacetic ester of formula III (X is halogen), thus giving the compound of formula I. The hydrolysis of the product forms the compound of formula IV, which has anti-inflammatory activity.
COPYRIGHT: (C)1981,JPO&Japio
JP8692980A 1980-06-26 1980-06-26 Production of heterocyclic compound Granted JPS5636472A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8692980A JPS5636472A (en) 1980-06-26 1980-06-26 Production of heterocyclic compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8692980A JPS5636472A (en) 1980-06-26 1980-06-26 Production of heterocyclic compound

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP9746773A Division JPS5747671B2 (en) 1973-08-30 1973-08-30

Publications (2)

Publication Number Publication Date
JPS5636472A true JPS5636472A (en) 1981-04-09
JPS5748156B2 JPS5748156B2 (en) 1982-10-14

Family

ID=13900546

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8692980A Granted JPS5636472A (en) 1980-06-26 1980-06-26 Production of heterocyclic compound

Country Status (1)

Country Link
JP (1) JPS5636472A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS609744U (en) * 1983-06-30 1985-01-23 トヨタ自動車株式会社 Vehicle steering device

Also Published As

Publication number Publication date
JPS5748156B2 (en) 1982-10-14

Similar Documents

Publication Publication Date Title
JPS5495552A (en) Prostacyline derivative and its preparation
GB1503581A (en) Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds
JPS55115892A (en) 3-phosphonocephalosporanic acid derivative, its preparation, and medicine containing the same
JPS57169478A (en) Piperazine derivative
JPS5795984A (en) Pyridinecarboxamide derivative and its preparation
JPS5636472A (en) Production of heterocyclic compound
JPS559060A (en) Thia(oxa)zolidinecarboxylic acid derivative and its prepatation
JPS5289695A (en) Novel 7alpha-methoxycephalosporins and preparation thereof
JPS579771A (en) Tetrazole derivative
JPS572290A (en) Production of penem-3-carboxylic derivative
JPS5746977A (en) Novel prostacyclin and its preparation
JPS5466695A (en) Azetidinone derivative and its preparation
JPS55118494A (en) Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it
JPS5553291A (en) Naphthylidine derivative and its preparation
JPS57165382A (en) Fluoro-pgi2 compound and its preparation
GB1079726A (en) Method of producing a new salicylic acid ester
JPS55145669A (en) 8,10-diazaprostanoic acid derivative and its preparation
JPS5520740A (en) Aminoalkoxybibenzyl and its acid addition salt
JPS5492956A (en) 2-oxobenzothiazoline fatty acid amide and its preparation
JPS5511501A (en) Novel 7-methoxycephalosporin
JPS54135791A (en) 7-methoxycephalosporin compound, its preparation, and antibacterial agent containing the compound as main component
JPS5547681A (en) Indolizidine-methanol derivative and its preparation
JPS54157583A (en) Dibenzothiepin derivative and its preparation
JPS5513242A (en) N-isobutylamide derivative
JPS5610168A (en) Pyridine carboxylic acid amide derivative and its production